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Glenson Samuel, MD

TitleFaculty Physician, Division of Hematology/Oncology/BMT
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gilham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0003-0344-278X Additional info
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    Other Positions
    TitleAssistant Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleClinical Assistant Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Sri Ramachandra Medical College and Research Institute, Chennai, IndiaMD2005
    Southern Illinois University School of Medicine, Springfield, ILResidency2010Pediatrics
    Children's Mercy Hospital and Clinics, Kansas City, MOFellowship2014Hematology/Oncology

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Samuel's laboratory focus is currently in the field of pediatric sarcoma translational research; the main emphasis is in potential biomarkers related to Ewing Sarcoma derived exosomes in the pediatric population. Other ongoing collaborative research is on novel therapeutics for refractory or recurrent Ewing Sarcoma and Osteosarcoma patients.
    Collapse research activities and funding
         (SAMUEL, GLENSON)Jul 1, 2014 - Jun 30, 2017
    Alex's Lemonade Stand Young Investigator
    Exosomes as Biomarkers to Monitor Disease Progression and Response to Therapy in Ewing Sarcoma
    Role Description: For the first time to characterize exosomes released from Ewing sarcoma tumor cells and to study their unique contents in order to develop a biomarker for tumor presence/recurrence and response to treatment.
    Role: Principal Investigator

         (SAMUEL, GLENSON)Aug 1, 2016
    Noah’s Bandage Project Foundation
    Exosomes as biomarkers of disease and therapy-resistance in Ewing Sarcoma
    Role Description: Characterize and Identify predictive exosome-based microRNA biomarkers of chemoresistance and disease recurrence for Ewing sarcoma.
    Role: Principal Investigator

         (SAMUEL, GLENSON)Sep 1, 2016 - Aug 31, 2018
    Braden's Hope Foundation Cancer Research Program
    Exosome miRNAs as biomarkers and targets for chemoresistance in Ewing Sarcoma
    Role Description: exploitation of Ewing Sarcoma tumor derived exosomal microRNAs (miRNAs) in order to provide a simple and cost effective “liquid biopsy” and the identification of potential therapeutic targets to combat chemoresistance based on these exosomal microRNA biomarkers.
    Role: Co-Principal Investigator

    R33CA214333     (ZENG, YONG)May 10, 2017 - Apr 30, 2020
    NIH
    Integrated exosomes profiling for minimally invasive diagnosis and monitoring of cancer
    Role: Co-Investigator

         (SAMUEL, GLENSON)Nov 6, 2017
    Noah’s Bandage Project Foundation
    Identifying novel kinesin inhibitors for the therapeutic management of recurrent and/or progressive pediatric Ewing Sarcoma and Osteosarcoma
    Role Description: Discovery and validation of combination kinesin motor protein inhibitors both in vitro and in vivo for the purpose of use in pediatric patients with recurrent or progressive (refractory) Ewing Sarcoma and Osteosarcoma
    Role: Co-Principal Investigator

         (SAMUEL, GLENSON)Dec 31, 2019 - Sep 30, 2021
    Hyundai Hope on Wheels Young Investigator
    Exosomal microRNAs to enhance chemosensitivity and advance precision medicine in pediatric Ewing Sarcoma
    Role Description: Identify and design therapeutically relevant miRNA mimic or trap payloads to enhance chemotherapy sensitivity in Ewing Sarcoma cells. Combination of bioinformatic tools and in vitro assays will be used to refine 63 previously identified miRNAs and isolate specific miRNAs which may impact chemosensitivity within a panel of 8 Ewing Sarcoma cell lines. Engineer exosomes to deliver therapeutically relevant miRNA mimic or trap payloads to EWS cells and tumors.

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Crow J, Samuel G, Godwin AK. Beyond tumor mutational burden: potential and limitations in using exosomes to predict response to immunotherapy. Expert Rev Mol Diagn. 2019 12; 19(12):1079-1088. PMID: 31687863.
      View in: PubMed
    2. Ma Y, Baltezor M, Rajewski L, Crow J, Samuel G, Staggs VS, Chastain KM, Toretsky JA, Weir SJ, Godwin AK. Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. J Mol Med (Berl). 2019 07; 97(7):957-972. PMID: 31025088.
      View in: PubMed
    3. Zhang P, Crow J, Lella D, Zhou X, Samuel G, Godwin AK, Zeng Y. Ultrasensitive quantification of tumor mRNAs in extracellular vesicles with an integrated microfluidic digital analysis chip. Lab Chip. 2018 12 04; 18(24):3790-3801. PMID: 30474100.
      View in: PubMed
    4. Zhang P, Samuel G, Crow J, Godwin AK, Zeng Y. Molecular assessment of circulating exosomes toward liquid biopsy diagnosis of Ewing sarcoma family of tumors. Transl Res. 2018 11; 201:136-153. PMID: 30031766.
      View in: PubMed
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