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Francesco De Luca, MD

TitleDivision Director, Pediatric Endocrinology
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address3101 Broadway
Kansas City MO 64111
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    Other Positions
    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleClinical Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Catholic University of Sacred Heart, Rome, ItalyMD1983
    Catholic University of Sacred Heart, Rome, ItalyResidency1987Pediatrics
    St. Christopher's Hospital for Children, Philadelphia, PAFellowship1991Pediatric Endocrinology
    Albert Einstein Medical Center, Philadelphia, PAResidency1994Pediatrics
    NICHD, NIH, Bethesda, MDFellowship1998Pediatric Endocrinology

    Collapse Research 
    Collapse research overview
    Dr. De Luca's main research interest has been study of the molecular mechanisms governing longitudinal bone growth and, in turn, statural growth. Most of his research findings,obtained in vitro and in whole animal models,have elucidated the function of many paracrine (local) factors expressed in the cartilaginous growth plate of the long bones. These factors modulate growth plate chondrocyte proliferation and hypertrophy/differentiation, which are the main cellular events responsible for bone elongation.

    Another research interest of Dr. De Luca's is the study of the metabolic derangements associated with pediatric obesity. Specifically, his research group focused its attention especially on less known aspects of insulin resistance in children, such as sleep disorders, pre-hypertension, and oxidative stress. He is currently contributing to a number of research projects led by other faculty in his division on the efficacy and safety of metformin in children with a high risk to develop metabolic syndrome and type 2 diabetes.

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wu S, Flint JK, Rezvani G, De Luca F. Withdrawal: Nuclear factor-?B p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. J Biol Chem. 2020 Sep 25; 295(39):13691. PMID: 32978329.
      View in: PubMed
    2. De Luca F. Regulatory role of NF-?B in growth plate chondrogenesis and its functional interaction with Growth Hormone. Mol Cell Endocrinol. 2020 08 20; 514:110916. PMID: 32569858.
      View in: PubMed
    3. Pinhas-Hamiel O, De Luca F, Allen DB. Pediatric Endocrinology:Principles and Practice (McGraw Hill). Normal Grow5th and Growth Disorders. 2020.
    4. Wu S, Zhang Y, De Luca F. The effect of a high-calorie diet on bone growth is mediated by the insulin receptor. Bone. 2019 05; 122:166-175. PMID: 30798001.
      View in: PubMed
    5. Picozzi A, De Luca F. Depression and glycemic control in adolescent diabetics: evaluating possible association between depression and hemoglobin A1C. Public Health. 2019; (170):31-37.
    6. De Luca F. Regulatory Role for Growth Hormone in Statural Growth: IGF-Dependent and IGF-Independent Effects on Growth Plate Chondrogenesis and Longitudinal Bone Growth. Pediatr Endocrinol Rev. 2018 Sep; 16(Suppl 1):33-38. PMID: 30378781.
      View in: PubMed
    7. Gat-Yablonski G, De Luca F. Effect of Nutrition on Statural Growth?. Horm Res Paediatr. 2017; 88(1):46-62. PMID: 28365689.
      View in: PubMed
    8. Carvalho KS, Grunwald T, De Luca F. Neurological Complications of Endocrine Disease. Semin Pediatr Neurol. 2017 02; 24(1):33-42. PMID: 28779864.
      View in: PubMed
    9. De Luca F. Role of Nuclear Factor Kappa B (NF-?B) in Growth Plate Chondrogenesis. Pediatr Endocrinol Rev. 2016 Jun; 13(4):720-30. PMID: 27464415.
      View in: PubMed
    10. De Luca F. Endocrinological Abnormalities in Autism. Semin Pediatr Neurol. 2020 Oct; 35:100582. PMID: 32892953.
      View in: PubMed
    11. Wit JM, de Luca F. Atypical defects resulting in growth hormone insensitivity. Growth Horm IGF Res. 2016 06; 28:57-61. PMID: 26670721.
      View in: PubMed
    12. Shoar Z, Goldenthal MJ, De Luca F, Suarez E. Mitochondrial DNA content and function, childhood obesity, and insulin resistance. Endocr Res. 2016; 41(1):49-56. PMID: 26513277.
      View in: PubMed
    13. Baron J, S?vendahl L, De Luca F, Dauber A, Phillip M, Wit JM, Nilsson O. Short and tall stature: a new paradigm emerges. Nat Rev Endocrinol. 2015 Dec; 11(12):735-46. PMID: 26437621.
      View in: PubMed
    14. Wu S, Yang W, De Luca F. Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth. Endocrinology. 2015 Jul; 156(7):2541-51. PMID: 25910049.
      View in: PubMed
    15. Grunwald T, De Luca F. Role of Fibroblast Growth Factor 21 (FGF21) in the Regulation of Statural Growth. Curr Pediatr Rev. 2015; 11(2):98-105. PMID: 26133178.
      View in: PubMed
    16. Dunne C, De Luca F. Long-Term Follow-Up of a Child with Autoimmune Thyroiditis and Recurrent Hyperthyroidism in the Absence of TSH Receptor Antibodies. Case Rep Endocrinol. 2014; 2014:749576. PMID: 25114812.
      View in: PubMed
    17. Shoar Z, Ganguly T, Anderson CE, De Luca F, Suarez E. Absence of WNT4 gene mutation in a patient with MURCS association. J Pediatr Endocrinol Metab. 2014 May; 27(5-6):555-9. PMID: 24356390.
      View in: PubMed
    18. Wu S, Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F. Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression. J Biol Chem. 2013 Sep 20; 288(38):27375-27383. PMID: 23940039.
      View in: PubMed
    19. Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Gra?a X. Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55a holoenzyme. Mol Cell Biol. 2013 Aug; 33(16):3330-42. PMID: 23775125.
      View in: PubMed
    20. Shoar Z, Dunne C, Yorns W, De Luca F, Rezvani G. Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female. J Pediatr Endocrinol Metab. 2013; 26(5-6):561-4. PMID: 23515102.
      View in: PubMed
    21. Shoar Z, Rezvani G, De Luca F. Type 1 diabetes mellitus in a patient with homozygous sickle cell anemia. J Pediatr Endocrinol Metab. 2013; 26(11-12):1205-7. PMID: 23813357.
      View in: PubMed
    22. Wu S, Levenson A, Kharitonenkov A, De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem. 2012 Jul 27; 287(31):26060-7. PMID: 22696219.
      View in: PubMed
    23. Kubicky RA, Dunne C, Nandi-Munshi D, De Luca F. Long-term effects of a non-intensive weight program on body mass index and metabolic abnormalities of obese children and adolescents. Int J Pediatr Endocrinol. 2012 Jun 08; 2012:16. PMID: 22682162.
      View in: PubMed
    24. Kubicky RA, Weiner E, Carlson B, De Luca F. Effect of prolonged discontinuation of L-thyroxine replacement in a child with congenital hypothyroidism. Case Rep Endocrinol. 2012; 2012:841947. PMID: 22953072.
      View in: PubMed
    25. Kubicky RA, Wu S, Kharitonenkov A, De Luca F. Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology. 2012 May; 153(5):2287-95. PMID: 22374976.
      View in: PubMed
    26. Wu S, Morrison A, Sun H, De Luca F. Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2. J Biol Chem. 2011 Jul 15; 286(28):24726-34. PMID: 21592969.
      View in: PubMed
    27. Ostrow V, Wu S, Aguilar A, Bonner R, Suarez E, De Luca F. Association between oxidative stress and masked hypertension in a multi-ethnic population of obese children and adolescents. J Pediatr. 2011 Apr; 158(4):628-633.e1. PMID: 21075381.
      View in: PubMed
    28. Wu S, Aguilar AL, Ostrow V, De Luca F. Insulin resistance secondary to a high-fat diet stimulates longitudinal bone growth and growth plate chondrogenesis in mice. Endocrinology. 2011 Feb; 152(2):468-75. PMID: 21106874.
      View in: PubMed
    29. Reiter EO, Mauras N, McCormick K, Kulshreshtha B, Amrhein J, De Luca F, O'Brien S, Armstrong J, Melezinkova H. Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT). J Pediatr Endocrinol Metab. 2010 Oct; 23(10):999-1009. PMID: 21158211.
      View in: PubMed
    30. Aguilar A, Ostrow V, De Luca F, Suarez E. Elevated ambulatory blood pressure in a multi-ethnic population of obese children and adolescents. J Pediatr. 2010 Jun; 156(6):930-935. PMID: 20223475.
      View in: PubMed
    31. Kubicky RA, Faerber EN, de Chadarevian JP, Wu S, Rezvani I, De Luca F. An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. Pediatrics. 2010 Feb; 125(2):e433-7. PMID: 20100762.
      View in: PubMed
    32. Wu S, Walenkamp MJ, Lankester A, Bidlingmaier M, Wit JM, De Luca F. Growth hormone and insulin-like growth factor I insensitivity of fibroblasts isolated from a patient with an I{kappa}B{alpha} mutation. J Clin Endocrinol Metab. 2010 Mar; 95(3):1220-8. PMID: 20080849.
      View in: PubMed
    33. Flint J, Wu S, Shott S, Suarez E, De Luca F. Relationships between osteoprotegerin (OPG), receptor activator of nuclear factor kappaB ligand (RANKL), and growth hormone (GH) secretory status in short children. J Pediatr Endocrinol Metab. 2009 Dec; 22(12):1105-12. PMID: 20333869.
      View in: PubMed
    34. Ostrow V, De Luca F. Long term follow-up of a child with ambiguous genitalia, mixed gonadal dysgenesis, and unusual mosaicism. J Pediatr Endocrinol Metab. 2009 Sep; 22(9):863-6. PMID: 19960897.
      View in: PubMed
    35. Aguilar A, Wu S, De Luca F. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms. Endocrinology. 2009 Jun; 150(6):2732-9. PMID: 19264869.
      View in: PubMed
    36. Wu S, Fadoju D, Rezvani G, De Luca F. Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65. J Biol Chem. 2008 Dec 05; 283(49):34037-44. PMID: 18922796.
      View in: PubMed
    37. Wu S, Flint JK, Rezvani G, De Luca F. Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. J Biol Chem. 2007 Nov 16; 282(46):33698-33706. PMID: 17884819.
      View in: PubMed
    38. Suarez EA, d'Alva CB, Campbell A, Miller-Horn J, Dever M, Faerber E, Medonca BB, Latronico AC, De Luca F. Absence of mutation in the follicle-stimulating hormone receptor gene in severe primary hypothyroidism associated with gonadal hyperstimulation. J Pediatr Endocrinol Metab. 2007 Aug; 20(8):923-31. PMID: 17937064.
      View in: PubMed
    39. Flint J, Kothare SV, Zihlif M, Suarez E, Adams R, Legido A, De Luca F. Association between inadequate sleep and insulin resistance in obese children. J Pediatr. 2007 Apr; 150(4):364-9. PMID: 17382111.
      View in: PubMed
    40. Wu S, De Luca F. Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth. Endocrinology. 2006 Aug; 147(8):3761-8. PMID: 16675523.
      View in: PubMed
    41. De Luca F. Impaired growth plate chondrogenesis in children with chronic illnesses. Pediatr Res. 2006 May; 59(5):625-9. PMID: 16627871.
      View in: PubMed
    42. Wu S, Yoshiko Y, De Luca F. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. J Biol Chem. 2006 Feb 24; 281(8):5120-7. PMID: 16377640.
      View in: PubMed
    43. Nilsson O, Marino R, De Luca F, Phillip M, Baron J. Endocrine regulation of the growth plate. Horm Res. 2005; 64(4):157-65. PMID: 16205094.
      View in: PubMed
    44. Wu S, Legido A, De Luca F. Effects of valproic acid on longitudinal bone growth. J Child Neurol. 2004 Jan; 19(1):26-30. PMID: 15032379.
      View in: PubMed
    45. Wu S, De Luca F. Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. J Biol Chem. 2004 Feb 06; 279(6):4642-7. PMID: 14612457.
      View in: PubMed
    46. Wu S, Palese T, Mishra OP, Delivoria-Papadopoulos M, De Luca F. Effects of Ca2+ sensing receptor activation in the growth plate. FASEB J. 2004 Jan; 18(1):143-5. PMID: 14597561.
      View in: PubMed
    47. De Luca F, Nilsson O, Baron J. . In: Lavin N, ed. Manual of Endocrinology and Metabolism, 5th edition. Lippincott Manual Series. 2019. . The Growth Plate.
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