Francesco De Luca, MD
Title | Division Director, Pediatric Endocrinology |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 3101 Broadway Kansas City MO 64111
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vCard | Download vCard |
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Title | Professor of Pediatrics |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Title | Clinical Professor of Pediatrics |
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Institution | University of Kansas Medical Center |
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Department | Pediatrics |
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Biography Catholic University of Sacred Heart, Rome, Italy | MD | 1983 | | Catholic University of Sacred Heart, Rome, Italy | Residency | 1987 | Pediatrics | St. Christopher's Hospital for Children, Philadelphia, PA | Fellowship | 1991 | Pediatric Endocrinology | Albert Einstein Medical Center, Philadelphia, PA | Residency | 1994 | Pediatrics | NICHD, NIH, Bethesda, MD | Fellowship | 1998 | Pediatric Endocrinology |
Research Dr. De Luca's main research interest has been study of the molecular mechanisms governing longitudinal bone growth and, in turn, statural growth. Most of his research findings,obtained in vitro and in whole animal models,have elucidated the function of many paracrine (local) factors expressed in the cartilaginous growth plate of the long bones. These factors modulate growth plate chondrocyte proliferation and hypertrophy/differentiation, which are the main cellular events responsible for bone elongation.
Another research interest of Dr. De Luca's is the study of the metabolic derangements associated with pediatric obesity. Specifically, his research group focused its attention especially on less known aspects of insulin resistance in children, such as sleep disorders, pre-hypertension, and oxidative stress. He is currently contributing to a number of research projects led by other faculty in his division on the efficacy and safety of metformin in children with a high risk to develop metabolic syndrome and type 2 diabetes.
Bibliography
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Wu S, Flint JK, Rezvani G, De Luca F. Withdrawal: Nuclear factor-?B p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. J Biol Chem. 2020 Sep 25; 295(39):13691. PMID: 32978329.
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De Luca F. Regulatory role of NF-?B in growth plate chondrogenesis and its functional interaction with Growth Hormone. Mol Cell Endocrinol. 2020 08 20; 514:110916. PMID: 32569858.
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Pinhas-Hamiel O, De Luca F, Allen DB. Pediatric Endocrinology:Principles and Practice (McGraw Hill). Normal Grow5th and Growth Disorders. 2020.
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Wu S, Zhang Y, De Luca F. The effect of a high-calorie diet on bone growth is mediated by the insulin receptor. Bone. 2019 05; 122:166-175. PMID: 30798001.
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Picozzi A, De Luca F. Depression and glycemic control in adolescent diabetics: evaluating possible association between depression and hemoglobin A1C. Public Health. 2019; (170):31-37.
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De Luca F. Regulatory Role for Growth Hormone in Statural Growth: IGF-Dependent and IGF-Independent Effects on Growth Plate Chondrogenesis and Longitudinal Bone Growth. Pediatr Endocrinol Rev. 2018 Sep; 16(Suppl 1):33-38. PMID: 30378781.
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Gat-Yablonski G, De Luca F. Effect of Nutrition on Statural Growth?. Horm Res Paediatr. 2017; 88(1):46-62. PMID: 28365689.
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Carvalho KS, Grunwald T, De Luca F. Neurological Complications of Endocrine Disease. Semin Pediatr Neurol. 2017 02; 24(1):33-42. PMID: 28779864.
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De Luca F. Role of Nuclear Factor Kappa B (NF-?B) in Growth Plate Chondrogenesis. Pediatr Endocrinol Rev. 2016 Jun; 13(4):720-30. PMID: 27464415.
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De Luca F. Endocrinological Abnormalities in Autism. Semin Pediatr Neurol. 2020 Oct; 35:100582. PMID: 32892953.
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Wit JM, de Luca F. Atypical defects resulting in growth hormone insensitivity. Growth Horm IGF Res. 2016 06; 28:57-61. PMID: 26670721.
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Shoar Z, Goldenthal MJ, De Luca F, Suarez E. Mitochondrial DNA content and function, childhood obesity, and insulin resistance. Endocr Res. 2016; 41(1):49-56. PMID: 26513277.
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Baron J, S?vendahl L, De Luca F, Dauber A, Phillip M, Wit JM, Nilsson O. Short and tall stature: a new paradigm emerges. Nat Rev Endocrinol. 2015 Dec; 11(12):735-46. PMID: 26437621.
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Wu S, Yang W, De Luca F. Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth. Endocrinology. 2015 Jul; 156(7):2541-51. PMID: 25910049.
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Grunwald T, De Luca F. Role of Fibroblast Growth Factor 21 (FGF21) in the Regulation of Statural Growth. Curr Pediatr Rev. 2015; 11(2):98-105. PMID: 26133178.
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Dunne C, De Luca F. Long-Term Follow-Up of a Child with Autoimmune Thyroiditis and Recurrent Hyperthyroidism in the Absence of TSH Receptor Antibodies. Case Rep Endocrinol. 2014; 2014:749576. PMID: 25114812.
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Shoar Z, Ganguly T, Anderson CE, De Luca F, Suarez E. Absence of WNT4 gene mutation in a patient with MURCS association. J Pediatr Endocrinol Metab. 2014 May; 27(5-6):555-9. PMID: 24356390.
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Wu S, Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F. Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression. J Biol Chem. 2013 Sep 20; 288(38):27375-27383. PMID: 23940039.
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Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Gra?a X. Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55a holoenzyme. Mol Cell Biol. 2013 Aug; 33(16):3330-42. PMID: 23775125.
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Shoar Z, Dunne C, Yorns W, De Luca F, Rezvani G. Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female. J Pediatr Endocrinol Metab. 2013; 26(5-6):561-4. PMID: 23515102.
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Shoar Z, Rezvani G, De Luca F. Type 1 diabetes mellitus in a patient with homozygous sickle cell anemia. J Pediatr Endocrinol Metab. 2013; 26(11-12):1205-7. PMID: 23813357.
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Wu S, Levenson A, Kharitonenkov A, De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem. 2012 Jul 27; 287(31):26060-7. PMID: 22696219.
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Kubicky RA, Dunne C, Nandi-Munshi D, De Luca F. Long-term effects of a non-intensive weight program on body mass index and metabolic abnormalities of obese children and adolescents. Int J Pediatr Endocrinol. 2012 Jun 08; 2012:16. PMID: 22682162.
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Kubicky RA, Weiner E, Carlson B, De Luca F. Effect of prolonged discontinuation of L-thyroxine replacement in a child with congenital hypothyroidism. Case Rep Endocrinol. 2012; 2012:841947. PMID: 22953072.
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Kubicky RA, Wu S, Kharitonenkov A, De Luca F. Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology. 2012 May; 153(5):2287-95. PMID: 22374976.
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Wu S, Morrison A, Sun H, De Luca F. Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2. J Biol Chem. 2011 Jul 15; 286(28):24726-34. PMID: 21592969.
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Ostrow V, Wu S, Aguilar A, Bonner R, Suarez E, De Luca F. Association between oxidative stress and masked hypertension in a multi-ethnic population of obese children and adolescents. J Pediatr. 2011 Apr; 158(4):628-633.e1. PMID: 21075381.
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Wu S, Aguilar AL, Ostrow V, De Luca F. Insulin resistance secondary to a high-fat diet stimulates longitudinal bone growth and growth plate chondrogenesis in mice. Endocrinology. 2011 Feb; 152(2):468-75. PMID: 21106874.
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Reiter EO, Mauras N, McCormick K, Kulshreshtha B, Amrhein J, De Luca F, O'Brien S, Armstrong J, Melezinkova H. Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT). J Pediatr Endocrinol Metab. 2010 Oct; 23(10):999-1009. PMID: 21158211.
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Aguilar A, Ostrow V, De Luca F, Suarez E. Elevated ambulatory blood pressure in a multi-ethnic population of obese children and adolescents. J Pediatr. 2010 Jun; 156(6):930-935. PMID: 20223475.
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Kubicky RA, Faerber EN, de Chadarevian JP, Wu S, Rezvani I, De Luca F. An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. Pediatrics. 2010 Feb; 125(2):e433-7. PMID: 20100762.
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Wu S, Walenkamp MJ, Lankester A, Bidlingmaier M, Wit JM, De Luca F. Growth hormone and insulin-like growth factor I insensitivity of fibroblasts isolated from a patient with an I{kappa}B{alpha} mutation. J Clin Endocrinol Metab. 2010 Mar; 95(3):1220-8. PMID: 20080849.
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Flint J, Wu S, Shott S, Suarez E, De Luca F. Relationships between osteoprotegerin (OPG), receptor activator of nuclear factor kappaB ligand (RANKL), and growth hormone (GH) secretory status in short children. J Pediatr Endocrinol Metab. 2009 Dec; 22(12):1105-12. PMID: 20333869.
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Ostrow V, De Luca F. Long term follow-up of a child with ambiguous genitalia, mixed gonadal dysgenesis, and unusual mosaicism. J Pediatr Endocrinol Metab. 2009 Sep; 22(9):863-6. PMID: 19960897.
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Aguilar A, Wu S, De Luca F. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms. Endocrinology. 2009 Jun; 150(6):2732-9. PMID: 19264869.
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Wu S, Fadoju D, Rezvani G, De Luca F. Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65. J Biol Chem. 2008 Dec 05; 283(49):34037-44. PMID: 18922796.
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Wu S, Flint JK, Rezvani G, De Luca F. Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. J Biol Chem. 2007 Nov 16; 282(46):33698-33706. PMID: 17884819.
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Suarez EA, d'Alva CB, Campbell A, Miller-Horn J, Dever M, Faerber E, Medonca BB, Latronico AC, De Luca F. Absence of mutation in the follicle-stimulating hormone receptor gene in severe primary hypothyroidism associated with gonadal hyperstimulation. J Pediatr Endocrinol Metab. 2007 Aug; 20(8):923-31. PMID: 17937064.
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Flint J, Kothare SV, Zihlif M, Suarez E, Adams R, Legido A, De Luca F. Association between inadequate sleep and insulin resistance in obese children. J Pediatr. 2007 Apr; 150(4):364-9. PMID: 17382111.
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Wu S, De Luca F. Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth. Endocrinology. 2006 Aug; 147(8):3761-8. PMID: 16675523.
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De Luca F. Impaired growth plate chondrogenesis in children with chronic illnesses. Pediatr Res. 2006 May; 59(5):625-9. PMID: 16627871.
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Wu S, Yoshiko Y, De Luca F. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. J Biol Chem. 2006 Feb 24; 281(8):5120-7. PMID: 16377640.
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Nilsson O, Marino R, De Luca F, Phillip M, Baron J. Endocrine regulation of the growth plate. Horm Res. 2005; 64(4):157-65. PMID: 16205094.
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Wu S, Legido A, De Luca F. Effects of valproic acid on longitudinal bone growth. J Child Neurol. 2004 Jan; 19(1):26-30. PMID: 15032379.
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Wu S, De Luca F. Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. J Biol Chem. 2004 Feb 06; 279(6):4642-7. PMID: 14612457.
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Wu S, Palese T, Mishra OP, Delivoria-Papadopoulos M, De Luca F. Effects of Ca2+ sensing receptor activation in the growth plate. FASEB J. 2004 Jan; 18(1):143-5. PMID: 14597561.
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De Luca F, Nilsson O, Baron J.
. In: Lavin N, ed. Manual of Endocrinology and Metabolism, 5th edition. Lippincott Manual Series. 2019.
. The Growth Plate.
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2003 | 2 | 2004 | 1 | 2005 | 2 | 2006 | 2 | 2007 | 3 | 2008 | 1 | 2009 | 3 | 2010 | 5 | 2011 | 2 | 2012 | 4 | 2013 | 4 | 2014 | 2 | 2015 | 5 | 2016 | 3 | 2017 | 1 | 2018 | 1 | 2019 | 2 | 2020 | 3 |
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