John M. Daniel IV, MD, MS
| Title | Associate Medical Director, Neonatal Intensive Care Unit |
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| Institution | Children's Mercy Kansas City |
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| Department | Neonatology |
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| Address | 2401 Gillham Rd Kansas City MO 64108
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| Title | Medical Director, Neonatal Extracorporeal Membrane Oxygenation (ECMO) |
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| Institution | Children's Mercy Kansas City |
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| Department | Neonatology |
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| Title | Clinical Assistant Professor |
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| Institution | University of Kansas Medical Center |
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| Department | Pediatrics |
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| Title | Associate Professor |
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| Institution | University of Missouri-Kansas City |
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| Department | Pediatrics |
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Biography | Wake Forest University, School of Medicine, Winston-Salem, NC | MD | 2011 | Medicine | | Palmetto Health Children's Hospital, Columbia, SC | Residency | 2014 | Pediatrics | | Kentucky Children's Hospital, Lexington, KY | Fellowship | 2017 | Neonatal-Perinatal Medicine | | University of Kentucky, College of Medicine, Lexington, KY | MS | 2014 | Clinical and Translational Science |
Overview Research My research interests lie at the intersection of advanced neonatal care and innovative therapeutic approaches for critically ill infants. Specifically, I focus on the following areas:
Neonatal Extracorporeal Membrane Oxygenation (ECMO): I am interested in exploring the indications, outcomes, and optimization of ECMO for neonates with severe respiratory and cardiac failure. My research aims to identify best practices and enhance the safety and efficacy of ECMO support in this vulnerable population.
Neonatal Dialysis: I seek to investigate the application of dialysis in neonates, particularly those with acute kidney injury or congenital anomalies affecting renal function. My work aims to improve dialysis techniques and protocols to minimize complications and improve renal recovery in these patients.
Innovative Care for Congenital Diaphragmatic Hernias (CDH): I am committed to advancing care strategies for infants diagnosed with CDH, including prenatal interventions, surgical techniques, and post-operative management. My research focuses on understanding the pathophysiology of CDH and developing evidence-based practices to enhance outcomes for affected infants.
Congenital Heart Disease (CHD): My research also encompasses the complexities of congenital heart disease in neonates. I aim to investigate early diagnosis, surgical interventions, and post-operative care strategies to improve survival rates and long-term health outcomes for infants with CHD.
Through these research endeavors, I aspire to contribute to the advancement of neonatal care, improve clinical outcomes, and ultimately enhance the quality of life for infants facing these critical health challenges.
NCT02951130 (Satyan Lakshminrusimha, MD) NICHD Neonatal Research Network Milrinone in Congenital Diaphragmatic Hernia Role Description: Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF). Pulmonary hypertension associated with CDH is frequently resistant to conventional pulmonary vasodilator therapy including inhaled nitric oxide (iNO). Increased pulmonary vascular resistance (PVR) can lead to right ventricular overload and dysfunction. In patients with CDH, left ventricular dysfunction, either caused by right ventricular overload or a relative underdevelopment of the left ventricle, is associated with poor prognosis. Milrinone is an intravenous inotrope and lusitrope (enhances cardiac systolic contraction and diastolic relaxation respectively) with pulmonary vasodilator properties and has been shown anecdotally to improve oxygenation in PPHN. Milrinone is commonly used during the management of CDH although no randomized trials have been performed to test its efficacy. Thirty percent of infants with CDH in the Children's Hospital Neonatal Database (CHND) and 22% of late-preterm and term infants with CDH in the Pediatrix database received milrinone. In the recently published VICI trial, 84% of patients with CDH received a vasoactive medication. In the current pilot trial, neonates with an antenatal or postnatal diagnosis of CDH will be randomized to receive milrinone or placebo to establish safety of this medication in CDH and test its efficacy in improving oxygenation. Role: Site Principle Investigator |
| NCT06153459 (Carl Backes, MD)Jan 1, 2024 NHLBI Cord Clamping Among Neonates With Congenital Heart Disease (CORD-CHD) Role Description: The goal of this clinical trial is to compare 2 different timepoints for clamping the umbilical cord at birth for term-born infants with a prenatal diagnosis of congenital heart disease (CHD). The main questions it aims to answer are:
Does Delayed Cord Clamping at 120 seconds (DCC-120) or Delayed Cord Clamping at 30 seconds (DCC-30) after birth lead to better health outcomes?
Does DCC-120 seconds or DCC-30 seconds after birth lead to better neuromotor outcomes at 22-26 months of infant age (postnatal)?
Participants will be asked to do the following:
Participate in either DCC-120 or DCC-30 at birth (randomized assignment).
Complete General Movements Assessment (GMA) at 3-4 months of infant age (postnatal), complete questionnaires / surveys at this time.
Complete questionnaires / surveys at 9-12 months of infant age (postnatal).
Complete Hammersmith Infant Neurological Examination (HINE), Developmental Assessment of Young Children 2 Edition (DAYC-2), and questionnaires / surveys at 22-26 months of infant age (postnatal).
Permit data collection from electronic medical records for both the mother and infant study participants.
Investigators will compare DCC-120 vs. DCC-30 to see which approach is more beneficial to both the mother and baby with CHD. Role: Site Principle Investigator |
Bibliography
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Stoops C, Perazzo SI, Rumpel JA, Mohamed T, South AM, Khattab M, Joseph C, Harer MW, Slagle CL, Revenis M, Daniel J. Current Practice of Kidney Support Therapy in the NICU: Results from a CHNC Survey. Am J Perinatol. 2025 Jun 10. PMID: 40494539.
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Godwin J, Daniel J, Chavez-Bueno S, Sampath V. Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates. Pediatr Infect Dis J. 2025 Jan 01; 44(1):44-46. PMID: 39082788.
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Sloan P, Johng S, Daniel JM, Rhee CJ, Mahmood B, Gravari E, Marshall S, Downey AG, Braski K, Gowda SH, Fernandes CJ, Dariya V, Haberman BE, Seabrook R, Makkar A, Gray BW, Cookson MW, Najaf T, Rintoul N, Hedrick HL, DiGeronimo R, Weems MF, Ades A, Chapman R, Grover TR, Keene S. A clinical consensus guideline for nutrition in infants with congenital diaphragmatic hernia from birth through discharge. J Perinatol. 2024 May; 44(5):694-701. PMID: 38627594.
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Cruz-Centeno N, Stewart S, Marlor DR, Rivard DC, Daniel JM, Oyetunji TA, Hendrickson RJ. Exchange of Extracorporeal Membrane Oxygenation Cannulas for Hemodialysis Catheters in Children Requiring Renal Replacement Therapy. Am Surg. 2024 Feb; 90(2):216-219. PMID: 37609992.
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Pappas LB, Erickson LA, Ricketts AM, Moehlmann ML, Hahn AM, Daniel JM. Pre-operative enteral feeding in single-ventricle CHD patients and necrotising enterocolitis risk. Cardiol Young. 2024 Feb; 34(2):364-369. PMID: 37434452.
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Harer MW, Rumpel JA, Stoops C, Slagle CL, Liberio B, Daniel J, Hoffman SB, Agarwal N, Khattab MG, Rais-Bahrami K, Perazzo S. Current state of renal NIRS monitoring in the NICU: results from a CHNC Survey. J Perinatol. 2023 Aug; 43(8):1047-1049. PMID: 36932136.
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Porta NFM, Naing K, Keene S, Grover TR, Hedrick H, Mahmood B, Seabrook R, Daniel Iv J, Harrison A, Weems MF, Yoder BA, DiGeronimo R, Haberman B, Dariya V, Guner Y, Rintoul NE, Murthy K. Variability for Age at Successful Extubation in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2023 02; 253:129-134.e1. PMID: 36202240.
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Mahmood B, Murthy K, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Seabrook R, Ali N, Chapman R, Daniel J, Harrison A, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Grover TR. Predicting treatment of pulmonary hypertension at discharge in infants with congenital diaphragmatic hernia. J Perinatol. 2022 Jan; 42(1):45-52. PMID: 34711937.
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Weems MF, Grover TR, Seabrook R, DiGeronimo R, Gien J, Keene S, Rintoul N, Daniel JM, Johnson Y, Guner Y, Zaniletti I, Murthy K. Analgesia, Sedation, and Neuromuscular Blockade in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2023 Mar; 40(4):415-423. PMID: 34044457.
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Seabrook RB, Grover TR, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Ali N, Chapman R, Daniel J, Harrison HA, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Murthy K. Treatment of pulmonary hypertension during initial hospitalization in a multicenter cohort of infants with congenital diaphragmatic hernia (CDH). J Perinatol. 2021 Apr; 41(4):803-813. PMID: 33649432.
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Grover TR, Weems MF, Brozanski B, Daniel J, Haberman B, Rintoul N, Walden A, Hedrick H, Mahmood B, Seabrook R, Murthy K, Zaniletti I, Keene S. Central Line Utilization and Complications in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2022 Oct; 29(14):1524-1532. PMID: 33535242.
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Bhandary P, Daniel JM, Skinner SC, Bacon MK, Hanna M, Bauer JA, Giannone P, Ballard HO. Case series of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy during extracorporeal life support. Perfusion. 2020 Oct; 35(7):700-706. PMID: 31971073.
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Daniel JM, Davidson LN, Havens JR, Bauer JA, Shook LA. Aromatherapy as an adjunctive therapy for neonatal abstinence syndrome: A pilot study. J Opioid Manag. 2020; 16(2):119-125. PMID: 32329887.
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Runkel BG, Fraser JD, Daniel JM, Carlson KM. Identification of Inadvertent Azygous Vein Cannulation Using Transthoracic Echocardiography During Venoarterial Extracorporeal Membrane Oxygenation Initiation. CASE (Phila). 2019 Apr; 3(2):67-70. PMID: 31049483.
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Daniel JM, Bernard PA, Skinner SC, Bhandary P, Ruzic A, Bacon MK, Ballard HO. Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis. J Pediatr Intensive Care. 2018 Mar; 7(1):7-13. PMID: 31073461.
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Daniel J, Ruzic A, Dalland J, Miller V, Hanna M. Management of mixed type congenital mesoblastic nephroma: Case series and review of the literature. J Neonatal Perinatal Med. 2017; 10(1):113-118. PMID: 28282819.
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Lalani A, Benson Ham P, Wise LJ, Daniel JM, Walters KC, Pipkin WL, Stansfield B, Hatley RM, Bhatia J. Management of Patients with Gastroschisis Requiring Extracorporeal Membrane Oxygenation for Concurrent Respiratory Failure. Am Surg. 2016 Sep; 82(9):768-72. PMID: 27670556.
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| Year | Publications |
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| 2016 | 1 | | 2017 | 2 | | 2019 | 1 | | 2020 | 2 | | 2021 | 4 | | 2022 | 1 | | 2023 | 3 | | 2024 | 2 | | 2025 | 1 |
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Morelli J, VanSickle J, Music-Aplenc L, Newton D, Oschman A, Daniel J. Treatment of severe hemolysis in a baby requiring multiple tandem extracorporeal support modalities and experimental monoclonal antibody therapy. The 41th Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2025Daniel, J. Chilling Tales from the NICU: A Cool Look at HIE aka Hypoxic Ischemic Encephalopathy (HIE): Etiology, Mechanisms, and Therapies. Association of Women’s Health, Obstetrics, and Neonatal Nurses Regional Conference. Kansas City, MO. October 2024Stoops C, Perazzo S, Rumple J, Mohamed T, South A, Khattab M, Joseph C, Harer M, Slegal C, Revenis M, Daniel J. Current Practice of Kidney Support Therapy in the NICU: Results from a CHNC Survey. Children’s Hospital Neonatal Consortium Annual Symposium, Denver, CO. October 2024Daniel J. Clinical Case Based Scenario: Hyper-ammonemia and CRRT, Children’s Hospital Neonatal Consortium Annual Symposium, Denver, CO. October 2024Daniel, J. Disseminated Intravascular Coagulation in Neonatal on ECMO. University of West Virginia, Congenital Cardiovascular Surgery, Grand Rounds. Morgantown, WV, USA (Virtual). July 2024Sharma, J; Ducrot, P; Sherman, A; Rao, K; Daniel, J. Impact of Secondary Diagnoses on Neonatal Respiratory ECMO Mortality and Complications. The 39th Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2023Gray, B; Digeronimo, R; Miquel-Verges, F; Daniel, J; Heyrend, C; Carr, N; Ryan; K. Neonatal ECMO: ECMO and Bronchopulmonary Dysplasia. Expert Panel and Moderated Discussion. 34th ELSO National Conference, Seattle, WA. September 2023Orrick, J; Charbonneau, J; Davidson, K; Oschman, A; and Daniel, J. A Cost-Analysis of Bivalirudin vs. Heparin in Neonatal ECMO. 34th ELSO National Conference, Seattle, WA. September 2023Gray, B; Digeronimo, R; Miquel-Verges, F; Daniel, J; Heyrend, C; Carr, N; Ryan; K. Neonatal ECMO: Next Gen Approaches for the Next Gen - Expert Panel and Moderated Discussion. 33th ELSO National Conference, Boston, MA. September 2022Daniel IV, John M. The 2AM call from the well-baby nursery…Your night just got a whole lot longer. 7th Annual Regional Neonatology Conference. Kansas City, MO. June 2021Meyer, K.; Davidson, K; Thompson, M., and Daniel, JM. The Use of Bivalirudin in Comparison to Heparin for Anticoagulation in Neonatal ECMO Patients. The 37th Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2021Digeronimo, B; Rintoul, N; Chapman, R; Daniel, JM. Neonatal Breakout Session. CRRT in Neonatal Sepsis. Expert Faculty Panel. The 37th Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2021Rao, K.; Daniel IV, J.M.; Pallotto, E.K.; Lewis, T.; and Oschman, A., Challenges of Encountering Infant Delirium on ECMO. The 35th Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2019Daniel IV, J.M.; Miller-Smith, L.; Reed, D.J.; Newton, D.E.; Haney, B.M.; and Pallotto, E.K. Management of ICH in Infants and Children on Extracorporeal Support: A Practice Guidelines. The 35th Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2019Daniel, JM. ECMO in Chronic Lung Disease: What is Reversible? Breakout Session: Optimal ECMO in Pediatrics. 30th ELSO National Conference. Austin, Texas. September 2019Daniel, IV, John M. Pulmonary Hypertension and Neonatal ECMO. 5th Annual Regional Neonatology Conference. Kansas City, KS. April 2019Daniel, IV, John M; When Well Babies Get Sick: Initial Management of Sick Babies Before They Get to the ICU. Clinical Advances in Pediatrics Symposium. Kansas City, KS. September 2018Daniel IV, JM.; Bacon, MK.; Bernard, PA., Slone, AL.; Montgomery, KA.; Carpenter, AW.; Skinner, SC.; Hanna, MH; Bhandary, P; Giannone, PJ.; Bauer, JA., and Ballard, HO. Coagulation management and blood conservation in neonates on ECMO: the potential value of an anti-xa based protocol. The 33nd Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. February 2017Daniel, IV, JM.; Bhandary, Pr; Ruzic, A; Skinner, SC; Bacon, MK; Bernard, PA, and Ballard, HO. Failure rates associated with polymethylpentene and non-polymethylpentene oxygenators in neonates undergoing non-cardiac extracorporeal support. Platform Presentation. The 32nd Annual Children’s National Medical Center Symposium: ECMO and Advanced Therapies for Respiratory Failure. Keystone, CO. March 2016
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