Zohreh Talebizadeh, PhD
Title | Research Faculty PhD |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 2401 Gillham Rd Kansas City MO 64108
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vCard | Download vCard |
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Title | Associate Professor of Pediatrics |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Biography University of Gendi-Shapour, Ahwaz, Iran | BS | 1988 | Genetics | University of Nebraska Medical Center, Omaha, NE | PhD | 2000 | Genetics | Children's Mercy Hospital, Kansas City | Post-doc | 2002 | Genetics |
2019 - 2021 | Newborn Screening Translational Research Network Steering Committee-member, ACMG |
Overview Research Zohreh Talebizadeh, PhD, is the Director of Autism and Neurodevelopmental Disorders Genetics Research Laboratory at Children's Mercy. Dr. Talebizadeh’s research interests focus on genetic and epigenetic factors underlying autism etiology. The integral parts of her research include: applying integrated system biology approaches (i.e., linking genomic and phenotypic data) with the focus on identification of autism spectrum subtypes and examining gene regulatory processes (e.g., X chromosome inactivation, noncoding RNAs, and alternative splicing). Her work on expression profiling of microRNAs was one of the first reports on the role of these regulatory factors in autism. Her novel multi-step subject stratification approach to address differences within and between families in autism has been highlighted by the autism research community. Most recently, she has published a paper, using a combination of experimental data and computational genomic analysis that provided the first line of evidence for the potential role of retrotransposed elements and noncoding RNAs in the etiology of autism. At the regional level, Dr. Talebizadeh plays a leadership role in the Neurodevelopmental Working Group organized by BioNexus KC as part of their Path to 2025 plan. In addition to her genetics research work, Dr. Talebizadeh leads a Patient Centered Outcomes Research Institute (PCORI) funded initiative called Autism Genetics and Outcomes that promotes partnership between genetics and outcomes researchers. She has been an active member of the following scientific societies: American Society of Human Genetics (1997-present), International Society for Autism Research (2006-present), and has served as a PCORI Ambassador (2016-present). Due to her unique dual expertise, i.e., leading both genetics and patient outcomes research studies, she was invited to serve a three-year term (2019-2022) on the Newborn Screening Translational Research Network Steering Committee, organized by the American College of Medical Genetics.
(Talebizadeh)Oct 1, 2001 - Sep 30, 2003 Hall Family Foundation Functional analysis of two missense mutations in the KCNQ4 potassium channel gene Role: Principle Investigator |
| (Talebizadeh)Dec 1, 2003 - Nov 30, 2004 Prader-Willi Alliance for Research Ghrelin and peptide YY levels and gene expression in Prader-Willi syndrome Role: Principle Investigator |
| (Talebizadeh)Apr 1, 2005 - Mar 30, 2007 Cure for Autism Now Foundation X chromosome inactivation and candidate gene studies in females with autism Role: Principle Investigator |
| #2578 (Talebizadeh)Aug 1, 2008 - Jul 30, 2010 Autism Speaks Potential role of non-coding RNAs in autism Role: Principle Investigator |
| (Talebizadeh)Dec 1, 2009 - May 30, 2011 Patton Trust Research Development Grants-KCALSI Autism Genetic Database (AGD): using bioinformatics to study the genetics of autism Role: Principle Investigator |
| (Chen)Jul 1, 2010 - Jun 30, 2011 Patton Trust Research Development Grants-KCALSI Identifying epistatic interactions in autism spectrum disorders Role: Co-Investigator |
| (Talebizadeh)Dec 1, 2010 - Nov 30, 2014 Morgan Family & Dreiseszun Family Foundations Establishing autism databank at CMH Role: Principle Investigator |
| (Talebizadeh)Jul 1, 2013 - Jun 30, 2014 Patton Trust Research Development Grants-KCALSI Analysis of circadian genes in autism: characterization of alternative splicing profile of JARID1 (KDM5) genes Role: Principle Investigator |
| W81XWH-14-1-0374 (Talebizadeh)Sep 30, 2014 - Mar 1, 2017 Department of Defense Autism and obesity: Co-occurring conditions or drugs Side effects? Role: Principle Investigator |
| (Beversdorf)Aug 1, 2015 - Feb 28, 2017 University of Missouri System (IDIC) Epigenetic and immune factors in the effect of maternal stress exposure on autism Role: Co-PI |
| EAIN-2419 (Talebizadeh)Jan 30, 2017 - Feb 1, 2019 PCORI Incorporating genetic data in PCOR studies: building a road map for stakeholder engagement Role: Principle Investigator |
| EAIN-3885 (Talebizadeh)Jan 30, 2017 - Feb 1, 2019 PCORI Incorporating genetics in patient-centered outcomes research: An engagement model for the autism research community Role: Principle Investigator |
| (Talebizadeh)Jul 1, 2019 - Dec 31, 2020 CM Seed Grant Autism Research Role: Principle Investigator |
| (Talebizadeh)Dec 1, 2019 - Nov 30, 2021 Mounts Family Autism Genetics Research Role: Principle Investigator |
Bibliography
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Talebizadeh Z, Shah A. The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses. Autism Res. 2020 Aug; 13(8):1286-1299. PMID: 32618145.
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Talebizadeh Z, Shah A, DiTacchio L. The potential role of a retrotransposed gene and a long noncoding RNA in regulating an X-linked chromatin gene (KDM5C): Novel epigenetic mechanism in autism. Autism Res. 2019 07; 12(7):1007-1021. PMID: 31087518.
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Talebizadeh Z. Lessons learned from the DFNA37 gene discovery odyssey. Genet Med. 2019 07; 21(7):1481-1482. PMID: 30531810.
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Booth KT, Askew JW, Talebizadeh Z, Huygen PLM, Eudy J, Kenyon J, Hoover D, Hildebrand MS, Smith KR, Bahlo M, Kimberling WJ, Smith RJH, Azaiez H, Smith SD. Splice-altering variant in COL11A1 as a cause of nonsyndromic hearing loss DFNA37. Genet Med. 2019 04; 21(4):948-954. PMID: 30245514.
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Talebizadeh Z, Shah A. Building a Bridge Between Genetics and Outcomes Research: Application in Autism (The AutGO Study). Patient. 2018 08; 11(4):451-462. PMID: 29508356.
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Beversdorf DQ. Phenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders. J Dev Behav Pediatr. 2016 10; 37(8):659-73. PMID: 27676697.
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Talebizadeh Z, Aldenderfer R, Wen Chen X. A proof-of-concept study: exon-level expression profiling and alternative splicing in autism using lymphoblastoid cell lines. Psychiatr Genet. 2014 Feb; 24(1):1-9. PMID: 23838881.
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Fan Q, Charnigo R, Talebizadeh Z, Dai H. Hypothesis testing in normal admixture models to detect heterogeneous genetic signals. Journal of Biometrics and Biostatistics. 2014.
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Talebizadeh Z, Shah A. Frontiers in Autism Research. W. H. Hu (editor). Chapter 5: The Impact of Integrative Unconventional Data Analysis Approaches on Advancing Autism Genetics Research. 2014; 99-117.
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Talebizadeh Z, Arking DE, Hu VW. A Novel Stratification Method in Linkage Studies to Address Inter- and Intra-Family Heterogeneity in Autism. PLoS One. 2013; 8(6):e67569. PMID: 23840741.
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Han B, Chen XW, Talebizadeh Z, Xu H. Genetic studies of complex human diseases: characterizing SNP-disease associations using Bayesian networks. BMC Syst Biol. 2012; 6 Suppl 3:S14. PMID: 23281790.
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Dai H, Charnigo R, Srivastava T, Talebizadeh Z, Ye S
. Integrating P-values for Genetic and Genomic Data Analysis. Journal of Biometrics and Biostatistics. 2012.
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Han B, Chen XW, Talebizadeh Z. FEPI-MB: identifying SNPs-disease association using a Markov Blanket-based approach. BMC Bioinformatics. 2011 Nov 24; 12 Suppl 12:S3. PMID: 22168374.
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Talebizadeh Z. Am J Hum Genet. Regulation of Gene Expression by Small RNAs. Reviewed by Zohreh Talebizadeh. 2010; 3(86):328-330.
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Matuszek G, Talebizadeh Z. Autism Genetic Database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites. BMC Med Genet. 2009 Sep 24; 10:102. PMID: 19778453.
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Talebizadeh Z, Butler MG, Theodoro MF. Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism. Autism Res. 2008 Aug; 1(4):240-50. PMID: 19360674.
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Bittel DC, Theodoro MF, Kibiryeva N, Fischer W, Talebizadeh Z, Butler MG. Comparison of X-chromosome inactivation patterns in multiple tissues from human females. J Med Genet. 2008 May; 45(5):309-13. PMID: 18156436.
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Bazeley PS, Shepelev V, Talebizadeh Z, Butler MG, Fedorova L, Filatov V, Fedorov A. snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions. Gene. 2008 Jan 31; 408(1-2):172-9. PMID: 18160232.
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Butler MG, Theodoro MF, Bittel DC, Kuipers PJ, Driscoll DJ, Talebizadeh Z. X-chromosome inactivation patterns in females with Prader-Willi syndrome. . 2007 Mar 01; 143A(5):469-75. PMID: 17036338.
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Theodoro MF, Talebizadeh Z, Butler MG. Body composition and fatness patterns in Prader-Willi syndrome: comparison with simple obesity. Obesity (Silver Spring). 2006 Oct; 14(10):1685-90. PMID: 17062796.
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Talebizadeh Z, Simon SD, Butler MG. X chromosome gene expression in human tissues: male and female comparisons. Genomics. 2006 Dec; 88(6):675-681. PMID: 16949791.
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Talebizadeh Z, Lam DY, Theodoro MF, Bittel DC, Lushington GH, Butler MG. Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism. J Med Genet. 2006 May; 43(5):e21. PMID: 16648374.
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Butler MG and Talebizadeh Z. Progress in Medical Genetics, M.A. Horry (editor). Chapter 7: Genetics of autism with emphasis on affected females. 2006; 149-182.
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Talebizadeh Z, Bittel DC, Veatch OJ, Kibiryeva N, Butler MG. Brief report: non-random X chromosome inactivation in females with autism. J Autism Dev Disord. 2005 Oct; 35(5):675-81. PMID: 16167093.
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Talebizadeh Z, Kibiryeva N, Bittel DC, Butler MG. Ghrelin, peptide YY and their receptors: gene expression in brain from subjects with and without Prader-Willi syndrome. Int J Mol Med. 2005 Apr; 15(4):707-11. PMID: 15754036.
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Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet. 2005 Apr; 42(4):318-21. PMID: 15805158.
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Talebizadeh Z, Butler MG. Insulin resistance and obesity-related factors in Prader-Willi syndrome: comparison with obese subjects. Clin Genet. 2005 Mar; 67(3):230-9. PMID: 15691361.
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Bittel DC, Kibiryeva N, Talebizadeh Z, Driscoll DJ, Butler MG. Microarray analysis of gene/transcript expression in Angelman syndrome: deletion versus UPD. Genomics. 2005 Jan; 85(1):85-91. PMID: 15607424.
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Talebizadeh Z, Bittel DC, Veatch OJ, Butler MG, Takahashi TN, Miles JH. Do known mutations in neuroligin genes (NLGN3 and NLGN4) cause autism? J Autism Dev Disord. 2004 Dec; 34(6):735-6. PMID: 15679194.
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Butler MG, Bittel DC, Talebizadeh Z. Plasma peptide YY and ghrelin levels in infants and children with Prader-Willi syndrome. J Pediatr Endocrinol Metab. 2004 Sep; 17(9):1177-84. PMID: 15506676.
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Butler MG, Bittel DC, Kibiryeva N, Talebizadeh Z, Thompson T. Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy. Pediatrics. 2004 Mar; 113(3 Pt 1):565-73. PMID: 14993551.
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Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. J Med Genet. 2003 Aug; 40(8):568-74. PMID: 12920063.
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Talebizadeh Z, Bittel DC, Miles JH, Takahashi N, Wang CH, Kibiryeva N, Butler MG. No association between HOXA1 and HOXB1 genes and autism spectrum disorders (ASD). J Med Genet. 2002 Nov; 39(11):e70. PMID: 12414832.
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Butler MG, Bittel D, Talebizadeh Z. Prader-Willi syndrome and a deletion/duplication within the 15q11-q13 region. J Med Genet. 2002 Mar; 39(3):202-4. PMID: 11897825.
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De Leenheer EM, Ensink RJ, Kunst HP, Marres HA, Talebizadeh Z, Declau F, Smith SD, Usami S, Van de Heyning PH, Van Camp G, Huygen PL, Cremers CW. DFNA2/KCNQ4 and its manifestations. Adv Otorhinolaryngol. 2002; 61:41-6. PMID: 12408061.
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Talebizadeh Z, Kelley PM, Askew JW, Beisel KW, Smith SD. Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss. Hum Mutat. 1999; 14(6):493-501. PMID: 10571947.
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Year | Publications |
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1999 | 1 | 2002 | 3 | 2003 | 1 | 2004 | 3 | 2005 | 5 | 2006 | 4 | 2007 | 3 | 2008 | 1 | 2009 | 1 | 2010 | 1 | 2011 | 1 | 2012 | 2 | 2013 | 1 | 2014 | 3 | 2016 | 1 | 2018 | 3 | 2019 | 1 | 2020 | 1 |
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