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Zohreh Talebizadeh, PhD

TitleResearch Faculty PhD
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Gendi-Shapour, Ahwaz, IranBS1988Genetics
    University of Nebraska Medical Center, Omaha, NEPhD2000Genetics
    Children's Mercy Hospital, Kansas CityPost-doc2002Genetics
    Collapse awards and honors
    2019 - 2021Newborn Screening Translational Research Network Steering Committee-member, ACMG

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Zohreh Talebizadeh, PhD, is the Director of Autism and Neurodevelopmental Disorders Genetics Research Laboratory at Children's Mercy. Dr. Talebizadeh’s research interests focus on genetic and epigenetic factors underlying autism etiology. The integral parts of her research include: applying integrated system biology approaches (i.e., linking genomic and phenotypic data) with the focus on identification of autism spectrum subtypes and examining gene regulatory processes (e.g., X chromosome inactivation, noncoding RNAs, and alternative splicing). Her work on expression profiling of microRNAs was one of the first reports on the role of these regulatory factors in autism. Her novel multi-step subject stratification approach to address differences within and between families in autism has been highlighted by the autism research community. Most recently, she has published a paper, using a combination of experimental data and computational genomic analysis that provided the first line of evidence for the potential role of retrotransposed elements and noncoding RNAs in the etiology of autism. At the regional level, Dr. Talebizadeh plays a leadership role in the Neurodevelopmental Working Group organized by BioNexus KC as part of their Path to 2025 plan. In addition to her genetics research work, Dr. Talebizadeh leads a Patient Centered Outcomes Research Institute (PCORI) funded initiative called Autism Genetics and Outcomes that promotes partnership between genetics and outcomes researchers. She has been an active member of the following scientific societies: American Society of Human Genetics (1997-present), International Society for Autism Research (2006-present), and has served as a PCORI Ambassador (2016-present). Due to her unique dual expertise, i.e., leading both genetics and patient outcomes research studies, she was invited to serve a three-year term (2019-2022) on the Newborn Screening Translational Research Network Steering Committee, organized by the American College of Medical Genetics.
    Collapse research activities and funding
         (Talebizadeh)Oct 1, 2001 - Sep 30, 2003
    Hall Family Foundation
    Functional analysis of two missense mutations in the KCNQ4 potassium channel gene
    Role: Principle Investigator

         (Talebizadeh)Dec 1, 2003 - Nov 30, 2004
    Prader-Willi Alliance for Research
    Ghrelin and peptide YY levels and gene expression in Prader-Willi syndrome
    Role: Principle Investigator

         (Talebizadeh)Apr 1, 2005 - Mar 30, 2007
    Cure for Autism Now Foundation
    X chromosome inactivation and candidate gene studies in females with autism
    Role: Principle Investigator

    #2578     (Talebizadeh)Aug 1, 2008 - Jul 30, 2010
    Autism Speaks
    Potential role of non-coding RNAs in autism
    Role: Principle Investigator

         (Talebizadeh)Dec 1, 2009 - May 30, 2011
    Patton Trust Research Development Grants-KCALSI
    Autism Genetic Database (AGD): using bioinformatics to study the genetics of autism
    Role: Principle Investigator

         (Chen)Jul 1, 2010 - Jun 30, 2011
    Patton Trust Research Development Grants-KCALSI
    Identifying epistatic interactions in autism spectrum disorders
    Role: Co-Investigator

         (Talebizadeh)Dec 1, 2010 - Nov 30, 2014
    Morgan Family & Dreiseszun Family Foundations
    Establishing autism databank at CMH
    Role: Principle Investigator

         (Talebizadeh)Jul 1, 2013 - Jun 30, 2014
    Patton Trust Research Development Grants-KCALSI
    Analysis of circadian genes in autism: characterization of alternative splicing profile of JARID1 (KDM5) genes
    Role: Principle Investigator

    W81XWH-14-1-0374     (Talebizadeh)Sep 30, 2014 - Mar 1, 2017
    Department of Defense
    Autism and obesity: Co-occurring conditions or drugs Side effects?
    Role: Principle Investigator

         (Beversdorf)Aug 1, 2015 - Feb 28, 2017
    University of Missouri System (IDIC)
    Epigenetic and immune factors in the effect of maternal stress exposure on autism
    Role: Co-PI

    EAIN-2419     (Talebizadeh)Jan 30, 2017 - Feb 1, 2019
    PCORI
    Incorporating genetic data in PCOR studies: building a road map for stakeholder engagement
    Role: Principle Investigator

    EAIN-3885     (Talebizadeh)Jan 30, 2017 - Feb 1, 2019
    PCORI
    Incorporating genetics in patient-centered outcomes research: An engagement model for the autism research community
    Role: Principle Investigator

         (Talebizadeh)Jul 1, 2019 - Dec 31, 2020
    CM Seed Grant
    Autism Research
    Role: Principle Investigator

         (Talebizadeh)Dec 1, 2019 - Nov 30, 2021
    Mounts Family
    Autism Genetics Research
    Role: Principle Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Talebizadeh Z, Shah A, DiTacchio L. The potential role of a retrotransposed gene and a long noncoding RNA in regulating an X-linked chromatin gene (KDM5C): Novel epigenetic mechanism in autism. Autism Res. 2019 07; 12(7):1007-1021. PMID: 31087518.
      View in: PubMed
    2. Talebizadeh Z. Lessons learned from the DFNA37 gene discovery odyssey. Genet Med. 2019 07; 21(7):1481-1482. PMID: 30531810.
      View in: PubMed
    3. Booth KT, Askew JW, Talebizadeh Z, Huygen PLM, Eudy J, Kenyon J, Hoover D, Hildebrand MS, Smith KR, Bahlo M, Kimberling WJ, Smith RJH, Azaiez H, Smith SD. Splice-altering variant in COL11A1 as a cause of nonsyndromic hearing loss DFNA37. Genet Med. 2019 04; 21(4):948-954. PMID: 30245514.
      View in: PubMed
    4. Talebizadeh Z, Shah A. Building a Bridge Between Genetics and Outcomes Research: Application in Autism (The AutGO Study). Patient. 2018 08; 11(4):451-462. PMID: 29508356.
      View in: PubMed
    5. Beversdorf DQ. Phenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders. J Dev Behav Pediatr. 2016 10; 37(8):659-73. PMID: 27676697.
      View in: PubMed
    6. Talebizadeh Z, Aldenderfer R, Wen Chen X. A proof-of-concept study: exon-level expression profiling and alternative splicing in autism using lymphoblastoid cell lines. Psychiatr Genet. 2014 Feb; 24(1):1-9. PMID: 23838881.
      View in: PubMed
    7. Fan Q, Charnigo R, Talebizadeh Z, Dai H. Hypothesis testing in normal admixture models to detect heterogeneous genetic signals. Journal of Biometrics and Biostatistics. 2014.
    8. Talebizadeh Z, Shah A. Frontiers in Autism Research. W. H. Hu (editor). Chapter 5: The Impact of Integrative Unconventional Data Analysis Approaches on Advancing Autism Genetics Research. 2014; 99-117.
    9. Talebizadeh Z, Arking DE, Hu VW. A Novel Stratification Method in Linkage Studies to Address Inter- and Intra-Family Heterogeneity in Autism. PLoS One. 2013; 8(6):e67569. PMID: 23840741.
      View in: PubMed
    10. Han B, Chen XW, Talebizadeh Z, Xu H. Genetic studies of complex human diseases: characterizing SNP-disease associations using Bayesian networks. BMC Syst Biol. 2012; 6 Suppl 3:S14. PMID: 23281790.
      View in: PubMed
    11. Dai H, Charnigo R, Srivastava T, Talebizadeh Z, Ye S . Integrating P-values for Genetic and Genomic Data Analysis. Journal of Biometrics and Biostatistics. 2012.
    12. Han B, Chen XW, Talebizadeh Z. FEPI-MB: identifying SNPs-disease association using a Markov Blanket-based approach. BMC Bioinformatics. 2011 Nov 24; 12 Suppl 12:S3. PMID: 22168374.
      View in: PubMed
    13. Talebizadeh Z. Am J Hum Genet. Regulation of Gene Expression by Small RNAs. Reviewed by Zohreh Talebizadeh. 2010; 3(86):328-330.
    14. Matuszek G, Talebizadeh Z. Autism Genetic Database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites. BMC Med Genet. 2009 Sep 24; 10:102. PMID: 19778453.
      View in: PubMed
    15. Talebizadeh Z, Butler MG, Theodoro MF. Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism. Autism Res. 2008 Aug; 1(4):240-50. PMID: 19360674.
      View in: PubMed
    16. Bittel DC, Theodoro MF, Kibiryeva N, Fischer W, Talebizadeh Z, Butler MG. Comparison of X-chromosome inactivation patterns in multiple tissues from human females. J Med Genet. 2008 May; 45(5):309-13. PMID: 18156436.
      View in: PubMed
    17. Bazeley PS, Shepelev V, Talebizadeh Z, Butler MG, Fedorova L, Filatov V, Fedorov A. snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions. Gene. 2008 Jan 31; 408(1-2):172-9. PMID: 18160232.
      View in: PubMed
    18. Butler MG, Theodoro MF, Bittel DC, Kuipers PJ, Driscoll DJ, Talebizadeh Z. X-chromosome inactivation patterns in females with Prader-Willi syndrome. Am J Med Genet A. 2007 Mar 01; 143A(5):469-75. PMID: 17036338.
      View in: PubMed
    19. Theodoro MF, Talebizadeh Z, Butler MG. Body composition and fatness patterns in Prader-Willi syndrome: comparison with simple obesity. Obesity (Silver Spring). 2006 Oct; 14(10):1685-90. PMID: 17062796.
      View in: PubMed
    20. Talebizadeh Z, Simon SD, Butler MG. X chromosome gene expression in human tissues: male and female comparisons. Genomics. 2006 Dec; 88(6):675-681. PMID: 16949791.
      View in: PubMed
    21. Talebizadeh Z, Lam DY, Theodoro MF, Bittel DC, Lushington GH, Butler MG. Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism. J Med Genet. 2006 May; 43(5):e21. PMID: 16648374.
      View in: PubMed
    22. Butler MG and Talebizadeh Z. Progress in Medical Genetics, M.A. Horry (editor). Chapter 7: Genetics of autism with emphasis on affected females. 2006; 149-182.
    23. Talebizadeh Z, Bittel DC, Veatch OJ, Kibiryeva N, Butler MG. Brief report: non-random X chromosome inactivation in females with autism. J Autism Dev Disord. 2005 Oct; 35(5):675-81. PMID: 16167093.
      View in: PubMed
    24. Talebizadeh Z, Kibiryeva N, Bittel DC, Butler MG. Ghrelin, peptide YY and their receptors: gene expression in brain from subjects with and without Prader-Willi syndrome. Int J Mol Med. 2005 Apr; 15(4):707-11. PMID: 15754036.
      View in: PubMed
    25. Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet. 2005 Apr; 42(4):318-21. PMID: 15805158.
      View in: PubMed
    26. Talebizadeh Z, Butler MG. Insulin resistance and obesity-related factors in Prader-Willi syndrome: comparison with obese subjects. Clin Genet. 2005 Mar; 67(3):230-9. PMID: 15691361.
      View in: PubMed
    27. Bittel DC, Kibiryeva N, Talebizadeh Z, Driscoll DJ, Butler MG. Microarray analysis of gene/transcript expression in Angelman syndrome: deletion versus UPD. Genomics. 2005 Jan; 85(1):85-91. PMID: 15607424.
      View in: PubMed
    28. Talebizadeh Z, Bittel DC, Veatch OJ, Butler MG, Takahashi TN, Miles JH. Do known mutations in neuroligin genes (NLGN3 and NLGN4) cause autism? J Autism Dev Disord. 2004 Dec; 34(6):735-6. PMID: 15679194.
      View in: PubMed
    29. Butler MG, Bittel DC, Talebizadeh Z. Plasma peptide YY and ghrelin levels in infants and children with Prader-Willi syndrome. J Pediatr Endocrinol Metab. 2004 Sep; 17(9):1177-84. PMID: 15506676.
      View in: PubMed
    30. Butler MG, Bittel DC, Kibiryeva N, Talebizadeh Z, Thompson T. Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy. Pediatrics. 2004 Mar; 113(3 Pt 1):565-73. PMID: 14993551.
      View in: PubMed
    31. Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. J Med Genet. 2003 Aug; 40(8):568-74. PMID: 12920063.
      View in: PubMed
    32. Talebizadeh Z, Bittel DC, Miles JH, Takahashi N, Wang CH, Kibiryeva N, Butler MG. No association between HOXA1 and HOXB1 genes and autism spectrum disorders (ASD). J Med Genet. 2002 Nov; 39(11):e70. PMID: 12414832.
      View in: PubMed
    33. Butler MG, Bittel D, Talebizadeh Z. Prader-Willi syndrome and a deletion/duplication within the 15q11-q13 region. J Med Genet. 2002 Mar; 39(3):202-4. PMID: 11897825.
      View in: PubMed
    34. De Leenheer EM, Ensink RJ, Kunst HP, Marres HA, Talebizadeh Z, Declau F, Smith SD, Usami S, Van de Heyning PH, Van Camp G, Huygen PL, Cremers CW. DFNA2/KCNQ4 and its manifestations. Adv Otorhinolaryngol. 2002; 61:41-6. PMID: 12408061.
      View in: PubMed
    35. Talebizadeh Z, Kelley PM, Askew JW, Beisel KW, Smith SD. Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss. Hum Mutat. 1999; 14(6):493-501. PMID: 10571947.
      View in: PubMed
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