Tom Curran, PhD, FRS
Title | Senior Vice President, Executive Director and Chief Scientific Officer, Children's Research Institute |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 2401 Gillham Rd Kansas City MO 64108
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ORCID
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Title | Donald J. Hall Eminent Scholar in Pediatric Research |
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Institution | Children's Mercy Kansas City |
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Department | Children's Research Institute |
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Title | Professor of Pediatrics |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Title | Research Professor of Pediatrics |
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Institution | University of Kansas Medical Center |
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Department | Cancer Biology |
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Title | Adjunct Professor of Biomedical Sciences |
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Institution | Kansas City University of Medicine & Biosciences |
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Department | Biomedical Sciences |
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Biography Imperial Cancer Research Fund Laboratories and University College London, London, UK | PhD | 1982 | Zoology and Anatomy | Salk Institute, San Diego, CA | Fellowship | 1984 | | Edinburgh University, Scotland | BSc (Hons 1st class) | 1978 | Biological Sciences (Zoology) |
1978 | Ashworth Prize in Zoology, Edinburgh University | 1992 | Tenovus-Scotland Medal, Glasgow University | 1992 | Young Scientist Award, Passano Foundation | 1992 | Rita Levi Montalcini Award in Neurosciences, Fidia Foundation | 1993 | Outstanding Achievement in Cancer Research, American Association for Cancer Research | 1994 | Fellow, American Association for Advancement of Science | 1994 | Golgi Award, Italian Academy of Neurosciences | 1994 | Fellow, American Academy of Microbiology | 2000 | President, American Association for Cancer Research | 2005 | Fellow, Royal Society, London | 2009 | Member, National Academy of Medicine | 2012 | Fellow, American Academy of Arts & Sciences | 2013 | Fellow, AACR Academy | 2015 | Fred Epstein Lifetime Achievement Award, Children's Brain Tumor Foundation | 2020 | Corresponding Fellow, Royal Society of Edinburgh |
Overview Research From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 300 papers that have been cited more than 74,000 times (Google Scholar).
Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.
Bibliography
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Sala A, Cameron JM, Brennan PM, Crosbie EJ, Curran T, Gray E, Martin-Hirsch P, Palmer DS, Rehman IU, Rattray NJW, Baker MJ. Global serum profiling: an opportunity for earlier cancer detection. J Exp Clin Cancer Res. 2023 Aug 15; 42(1):207. PMID: 37580713.
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Cheung WA, Johnson AF, Rowell WJ, Farrow E, Hall R, Cohen ASA, Means JC, Zion TN, Portik DM, Saunders CT, Koseva B, Bi C, Truong TK, Schwendinger-Schreck C, Yoo B, Johnston JJ, Gibson M, Evrony G, Rizzo WB, Thiffault I, Younger ST, Curran T, Wenger AM, Grundberg E, Pastinen T. Direct haplotype-resolved 5-base HiFi sequencing for genome-wide profiling of hypermethylation outliers in a rare disease cohort. Nat Commun. 2023 05 29; 14(1):3090. PMID: 37248219.
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Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, Jerrick To TK, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M. Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Cell Rep. 2023 May 25; 42(6):112600. PMID: 37235472.
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Cohen ASA, Farrow EG, Abdelmoity AT, Alaimo JT, Amudhavalli SM, Anderson JT, Bansal L, Bartik L, Baybayan P, Belden B, Berrios CD, Biswell RL, Buczkowicz P, Buske O, Chakraborty S, Cheung WA, Coffman KA, Cooper AM, Cross LA, Curran T, Dang TTT, Elfrink MM, Engleman KL, Fecske ED, Fieser C, Fitzgerald K, Fleming EA, Gadea RN, Gannon JL, Gelineau-Morel RN, Gibson M, Goldstein J, Grundberg E, Halpin K, Harvey BS, Heese BA, Hein W, Herd SM, Hughes SS, Ilyas M, Jacobson J, Jenkins JL, Jiang S, Johnston JJ, Keeler K, Korlach J, Kussmann J, Lambert C, Lawson C, Le Pichon JB, Leeder JS, Little VC, Louiselle DA, Lypka M, McDonald BD, Miller N, Modrcin A, Nair A, Neal SH, Oermann CM, Pacicca DM, Pawar K, Posey NL, Price N, Puckett LMB, Quezada JF, Raje N, Rowell WJ, Rush ET, Sampath V, Saunders CJ, Schwager C, Schwend RM, Shaffer E, Smail C, Soden S, Strenk ME, Sullivan BR, Sweeney BR, Tam-Williams JB, Walter AM, Welsh H, Wenger AM, Willig LK, Yan Y, Younger ST, Zhou D, Zion TN, Thiffault I, Pastinen T. Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes. Genet Med. 2022 06; 24(6):1336-1348. PMID: 35305867.
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Cameron JM, Brennan PM, Antoniou G, Butler HJ, Christie L, Conn JJA, Curran T, Gray E, Hegarty MG, Jenkinson MD, Orringer D, Palmer DS, Sala A, Smith BR, Baker MJ. Clinical validation of a spectroscopic liquid biopsy for earlier detection of brain cancer. Neurooncol Adv. 2022; 4(1):vdac024. PMID: 35316978.
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Abdel-Rahman SM, Wimes MP, Curran T. A call to action: Issuing a diversity and inclusion challenge to research organizations. Clin Transl Sci. 2021 11; 14(6):2095-2098. PMID: 34191409.
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Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, To TKJ, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M. Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Cell Rep. 2021 03 30; 34(13):108917. PMID: 33789113.
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Fan Q, Gong T, Zheng C, Ng JMY, Chen J, Myers C, Hensley H, Curran T, Yang ZJ. Statins repress hedgehog signaling in medulloblastoma with no bone toxicities. Oncogene. 2021 03; 40(12):2258-2272. PMID: 33649536.
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Park T, Large N, Curran T. Quantitative assessment of glioblastoma phenotypes in?vitro establishes cell migration as a robust readout of Crk and CrkL activity. J Biol Chem. 2021 Jan-Jun; 296:100390. PMID: 33561443.
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Park T, Curran T. Requirement for Crk and CrkL during postnatal lens development. Biochem Biophys Res Commun. 2020 08 27; 529(3):603-607. PMID: 32736680.
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Du F, Yuelling L, Lee EH, Wang Y, Liao S, Cheng Y, Zhang L, Zheng C, Peri S, Cai KQ, Ng JMY, Curran T, Li P, Yang ZJ. Leukotriene Synthesis Is Critical for Medulloblastoma Progression. Clin Cancer Res. 2019 11 01; 25(21):6475-6486. PMID: 31300449.
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Curran T. Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer. Open Biol. 2018 08; 8(8). PMID: 30068568.
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Gordon RE, Zhang L, Peri S, Kuo YM, Du F, Egleston BL, Ng JMY, Andrews AJ, Astsaturov I, Curran T, Yang ZJ. Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. Clin Cancer Res. 2018 03 15; 24(6):1375-1388. PMID: 29437795.
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Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X. Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 01 23; 7. PMID: 29360039.
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Liu Y, Yuelling LW, Wang Y, Du F, Gordon RE, O'Brien JA, Ng JMY, Robins S, Lee EH, Liu H, Curran T, Yang ZJ. Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion. Cancer Res. 2017 12 01; 77(23):6692-6703. PMID: 28986380.
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Park T, Koptyra M, Curran T. Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL). J Biol Chem. 2016 Dec 16; 291(51):26273-26290. PMID: 27807028.
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Li P, Lee EH, Du F, Gordon RE, Yuelling LW, Liu Y, Ng JM, Zhang H, Wu J, Korshunov A, Pfister SM, Curran T, Yang ZJ. Nestin Mediates Hedgehog Pathway Tumorigenesis. Cancer Res. 2016 09 15; 76(18):5573-83. PMID: 27496710.
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Melo FM, Couto PP, Bale AE, Bastos-Rodrigues L, Passos FM, Lisboa RG, Ng JM, Curran T, Dias EP, Friedman E, De Marco L. Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma. Cancer Genet. 2016 06; 209(6):251-7. PMID: 27245436.
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Ng JM, Martinez D, Marsh ED, Zhang Z, Rappaport E, Santi M, Curran T. Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53. Cancer Res. 2015 Nov 01; 75(21):4629-39. PMID: 26363008.
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Dang MT, Wehrli S, Dang CV, Curran T. The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice. PLoS One. 2015; 10(7):e0133633. PMID: 26192445.
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Robinson GW, Orr BA, Wu G, Gururangan S, Lin T, Qaddoumi I, Packer RJ, Goldman S, Prados MD, Desjardins A, Chintagumpala M, Takebe N, Kaste SC, Rusch M, Allen SJ, Onar-Thomas A, Stewart CF, Fouladi M, Boyett JM, Gilbertson RJ, Curran T, Ellison DW, Gajjar A. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. J Clin Oncol. 2015 Aug 20; 33(24):2646-54. PMID: 26169613.
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Huang Y, Clarke F, Karimi M, Roy NH, Williamson EK, Okumura M, Mochizuki K, Chen EJ, Park TJ, Debes GF, Zhang Y, Curran T, Kambayashi T, Burkhardt JK. CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest. 2015 Mar 02; 125(3):1019-32. PMID: 25621495.
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Koptyra M, Park TJ, Curran T. Crk and CrkL are required for cell transformation by v-fos and v-ras. Mol Carcinog. 2016 Jan; 55(1):97-104. PMID: 25557916.
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Park TJ, Curran T. Neurobiology: Reelin mediates form and function. Curr Biol. 2014 Nov 17; 24(22):R1089-92. PMID: 25458219.
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Kim J, Park TJ, Kwon N, Lee D, Kim S, Kohmura Y, Ishikawa T, Kim KT, Curran T, Je JH. Dendritic planarity of Purkinje cells is independent of Reelin signaling. Brain Struct Funct. 2015 Jul; 220(4):2263-73. PMID: 24828132.
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George B, Fan Q, Dlugos CP, Soofi AA, Zhang J, Verma R, Park TJ, Wong H, Curran T, Nihalani D, Holzman LB. Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis. Kidney Int. 2014 Jun; 85(6):1382-1394. PMID: 24499776.
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Park TJ, Curran T. Essential roles of Crk and CrkL in fibroblast structure and motility. Oncogene. 2014 Oct 23; 33(43):5121-32. PMID: 24166500.
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Gajjar A, Stewart CF, Ellison DW, Kaste S, Kun LE, Packer RJ, Goldman S, Chintagumpala M, Wallace D, Takebe N, Boyett JM, Gilbertson RJ, Curran T. Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clin Cancer Res. 2013 Nov 15; 19(22):6305-12. PMID: 24077351.
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Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Res. 2013 Apr 15; 73(8):2650-8. PMID: 23580576.
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Wang Y, Davidow L, Arvanites AC, Blanchard J, Lam K, Xu K, Oza V, Yoo JW, Ng JM, Curran T, Rubin LL, McMahon AP. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012 Aug 24; 19(8):972-82. PMID: 22921064.
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Curran T. Q&A: Tom Curran on translational research. Cancer Discov. 2012 Feb; 2(2):99. PMID: 22585839.
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George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb; 122(2):674-92. PMID: 22251701.
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Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA. The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. Nat Cell Biol. 2011 Dec 18; 14(1):87-92. PMID: 22179045.
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Tom Curran. Deconstructing the Mosaic Brain. The Scientist. LabX Media Group. 2011; 25(6):26-27.
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Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer. 2011 May 26; 11(7):493-501. PMID: 21614026.
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Brechbiel JL, Ng JM, Curran T. PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice. Toxicol Pathol. 2011 Apr; 39(3):478-85. PMID: 21411723.
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Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9. PMID: 21163964.
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Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61. PMID: 20978073.
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Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ. Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes Dev. 2010 Nov 01; 24(21):2451-61. PMID: 21041412.
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Curran T. Mouse models and mouse supermodels. EMBO Mol Med. 2010 Oct; 2(10):385-6; author reply 386-7. PMID: 20721989.
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Park TJ, Curran T. Alternative splicing disabled by Nova2. Neuron. 2010 Jun 24; 66(6):811-3. PMID: 20620865.
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T. Curran, Y. Christen (Eds). Two Faces of Evil: Cancer and Neurodegeneration, Research Perspectives in Alzheimer's Disease. Foundation IPSEN. Springer. 2010.
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Yip YP, Mehta N, Magdaleno S, Curran T, Yip JW. Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord. J Comp Neurol. 2009 Jul 10; 515(2):260-8. PMID: 19412957.
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Ng L, Ma M, Curran T, Forrest D. Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse. Neuroreport. 2009 Apr 22; 20(6):627-31. PMID: 19282790.
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Park TJ, Curran T. Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci. 2008 Dec 10; 28(50):13551-62. PMID: 19074029.
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Curran T, Ng JM. Cancer: Hedgehog's other great trick. Nature. 2008 Sep 18; 455(7211):293-4. PMID: 18800119.
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De Gasperi R, Gama Sosa MA, Wen PH, Li J, Perez GM, Curran T, Elder GA. Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. Dev Dyn. 2008 Sep; 237(9):2405-14. PMID: 18729224.
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Kimura H, Ng JM, Curran T. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell. 2008 Mar; 13(3):249-60. PMID: 18328428.
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Thomas Curran. The road to Osaka. The 20th Anniversary of the OSAKA Bioscience Institute Commemorative Publication. 2008; 97-99.
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Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol. 2007 Oct; 27(19):6706-17. PMID: 17646384.
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Lee Y, Kawagoe R, Sasai K, Li Y, Russell HR, Curran T, McKinnon PJ. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene. 2007 Sep 27; 26(44):6442-7. PMID: 17452975.
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Sasai K, Romer JT, Kimura H, Eberhart DE, Rice DS, Curran T. Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Cancer Res. 2007 Apr 15; 67(8):3871-7. PMID: 17413002.
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Park TJ, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol. 2006 Aug; 26(16):6272-82. PMID: 16880535.
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Lee Y, Miller HL, Russell HR, Boyd K, Curran T, McKinnon PJ. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 2006 Jul 15; 66(14):6964-71. PMID: 16849540.
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Liu J, Wang J, Huang Q, Higdon J, Magdaleno S, Curran T, Zuo J. Gene expression profiles of mouse retinas during the second and third postnatal weeks. Brain Res. 2006 Jul 07; 1098(1):113-25. PMID: 16777074.
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Brumwell CL, Curran T. Developmental mouse brain gene expression maps. J Physiol. 2006 Sep 01; 575(Pt 2):343-6. PMID: 16728446.
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Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, Curran T. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res. 2006 Apr 15; 66(8):4215-22. PMID: 16618744.
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Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr; 4(4):e86. PMID: 16602821.
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Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006 Apr 20; 24(12):1924-31. PMID: 16567768.
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Dellovade T, Romer JT, Curran T, Rubin LL. The hedgehog pathway and neurological disorders. Annu Rev Neurosci. 2006; 29:539-63. PMID: 16776596.
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Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 2005 Nov 15; 19(22):2656-67. PMID: 16260494.
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Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdaleno S, Dalton J, Calabrese C, Board J, Macdonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell. 2005 Oct; 8(4):323-35. PMID: 16226707.
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Curran T. Lost in translation: the future of cancer research? Clin Cancer Res. 2005 Jul 01; 11(13):4644-5. PMID: 16000555.
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Romer J, Curran T. Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res. 2005 Jun 15; 65(12):4975-8. PMID: 15958535.
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Kimura H, Stephen D, Joyner A, Curran T. Gli1 is important for medulloblastoma formation in Ptc1+/- mice. Oncogene. 2005 Jun 09; 24(25):4026-36. PMID: 15806168.
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Ordway JM, Fenster SD, Ruan H, Curran T. A transcriptome map of cellular transformation by the fos oncogene. Mol Cancer. 2005 May 26; 4(1):19. PMID: 15918904.
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Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T. A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20; 132(2):116-27. PMID: 15582152.
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Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran T. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell. 2004 Sep; 6(3):229-40. PMID: 15380514.
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Romer JT, Curran T. Medulloblastoma and retinoblastoma: oncology recapitulates ontogeny. Cell Cycle. 2004 Jul; 3(7):917-9. PMID: 15254429.
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Huang Y, Magdaleno S, Hopkins R, Slaughter C, Curran T, Keshvara L. Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins. Biochem Biophys Res Commun. 2004 May 21; 318(1):204-12. PMID: 15110774.
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Ordway JM, Williams K, Curran T. Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene. 2004 May 06; 23(21):3737-48. PMID: 14990994.
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Yip YP, Capriotti C, Magdaleno S, Benhayon D, Curran T, Nakajima K, Yip JW. Components of the reelin signaling pathway are expressed in the spinal cord. J Comp Neurol. 2004 Mar 01; 470(2):210-9. PMID: 14750162.
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Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel MF, Curran T, Gilbertson RJ, McKinnon PJ. A molecular fingerprint for medulloblastoma. Cancer Res. 2003 Sep 01; 63(17):5428-37. PMID: 14500378.
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Andersen OM, Benhayon D, Curran T, Willnow TE. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003 Aug 12; 42(31):9355-64. PMID: 12899622.
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Homayouni R, Magdaleno S, Keshvara L, Rice DS, Curran T. Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res. 2003 Jul 23; 115(2):121-9. PMID: 12877983.
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Curran T. From bings to biology: taking a different path in cancer research. Cancer Biol Ther. 2003 Jul-Aug; 2(4):456-9. PMID: 14508121.
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Yun M, Keshvara L, Park CG, Zhang YM, Dickerson JB, Zheng J, Rock CO, Curran T, Park HW. Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem. 2003 Sep 19; 278(38):36572-81. PMID: 12826668.
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Yang WQ, Senger D, Muzik H, Shi ZQ, Johnson D, Brasher PM, Rewcastle NB, Hamilton M, Rutka J, Wolff J, Wetmore C, Curran T, Lee PW, Forsyth PA. Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma. Cancer Res. 2003 Jun 15; 63(12):3162-72. PMID: 12810644.
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Ordway JM, Eberhart D, Curran T. Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding. Mol Cell Biol. 2003 Jun; 23(12):4257-66. PMID: 12773568.
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Li L, Connelly MC, Wetmore C, Curran T, Morgan JI. Mouse embryos cloned from brain tumors. Cancer Res. 2003 Jun 01; 63(11):2733-6. PMID: 12782575.
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Benhayon D, Magdaleno S, Curran T. Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Brain Res Mol Brain Res. 2003 Apr 10; 112(1-2):33-45. PMID: 12670700.
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Joseph V. Simone, MD, Bruce W. Stillman, PhD, Ellen Stovall, Diana Petitti, MD, Jill Bargonetti, PhD, Barry Bozeman, PhD, Tim Byers, MD, MPH, Tom Curran, PhD, Timothy Eberlein, MD, David Galas, PhD, Karen Hersey, JD, Daniel J. Kevles, PhD, Lauren Linton, PhD, MBA, William W. McGuire, MD, John Mendelsohn, MD, Kathleen H. Mooney, PhD, Nancy Mueller, ScD, Patricia A. Nolan, MD, MPH, Cecil B. Pickett, PhD, Stephen Prescott, MD, Louise B. Russell, PhD, Thomas J. Smith, MD, FACP, Susan Weiner, PhD, Robert C. Young, MD. Large-Scale Biomedical Science Exploring Strategies For Future Research Sc. The National Academies Press. Committee on Large-Scale Science and Cancer Research Sharyl J. Nass and Bruce W. Stillman (eds.). The National Academies Press. 2003.
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Gilbertson RJ, Bentley L, Hernan R, Junttila TT, Frank AJ, Haapasalo H, Connelly M, Wetmore C, Curran T, Elenius K, Ellison DW. ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clin Cancer Res. 2002 Oct; 8(10):3054-64. PMID: 12374672.
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Magdaleno S, Northcutt GM, Curran T, Kurschner C. mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain. Brain Res Gene Expr Patterns. 2002 Oct; 1(3-4):143-9. PMID: 12638124.
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Keshvara L, Magdaleno S, Benhayon D, Curran T. Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J Neurosci. 2002 Jun 15; 22(12):4869-77. PMID: 12077184.
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Ordway JM, Curran T. Methylation matters: modeling a manageable genome. Cell Growth Differ. 2002 Apr; 13(4):149-62. PMID: 11971815.
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Magdaleno S, Keshvara L, Curran T. Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron. 2002 Feb 14; 33(4):573-86. PMID: 11856531.
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Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 2002 Jan 24; 415(6870):436-42. PMID: 11807556.
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Curran T.: Fos. In: Encyclopedia of Cancer, 2nd Edition (J. R. Bertino, Ed.). Academic Press, San Diego. 2002; 2:243-248.
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Keshvara L, Magdaleno S, Benhayon D. Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. USA Patent Number US20020172990 A1. 2002.
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Magdaleno SM, Curran T. Brain development: integrins and the Reelin pathway. Curr Biol. 2001 Dec 11; 11(24):R1032-5. PMID: 11747842.
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Homayouni R, Rice DS, Curran T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem Biophys Res Commun. 2001 Nov 30; 289(2):539-47. PMID: 11716507.
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Rice DS, Nusinowitz S, Azimi AM, Mart?nez A, Soriano E, Curran T. The reelin pathway modulates the structure and function of retinal synaptic circuitry. Neuron. 2001 Sep 27; 31(6):929-41. PMID: 11580894.
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Ng L, Pedraza PE, Faris JS, Vennstr?m B, Curran T, Morreale de Escobar G, Forrest D. Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice. Neuroreport. 2001 Aug 08; 12(11):2359-62. PMID: 11496110.
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Keshvara L, Benhayon D, Magdaleno S, Curran T. Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J Biol Chem. 2001 May 11; 276(19):16008-14. PMID: 11279201.
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Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 2001 Jan 15; 61(2):513-6. PMID: 11212243.
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Rice DS, Curran T. Role of the reelin signaling pathway in central nervous system development. Annu Rev Neurosci. 2001; 24:1005-39. PMID: 11520926.
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Curran T and D'Arcangelo G. Interaction of Reelin with very low density lipoprotein (VLDL) receptor for screening and therapies. USA Patent Number 6,323,177. 2001.
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Rice DS, Curran T. Disabled-1 is expressed in type AII amacrine cells in the mouse retina. J Comp Neurol. 2000 Aug 21; 424(2):327-38. PMID: 10906706.
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Bernier B, Bar I, D'Arcangelo G, Curran T, Goffinet AM. Reelin mRNA expression during embryonic brain development in the chick. J Comp Neurol. 2000 Jul 03; 422(3):448-63. PMID: 10861519.
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Homayouni R, Curran T. Cortical development: Cdk5 gets into sticky situations. Curr Biol. 2000 May 04; 10(9):R331-4. PMID: 10801432.
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Wetmore C, Eberhart DE, Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res. 2000 Apr 15; 60(8):2239-46. PMID: 10786690.
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Single FN, Rozov A, Burnashev N, Zimmermann F, Hanley DF, Forrest D, Curran T, Jensen V, Hvalby O, Sprengel R, Seeburg PH. Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R). J Neurosci. 2000 Apr 01; 20(7):2558-66. PMID: 10729336.
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Rice DS, Curran T. Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev. 1999 Nov 01; 13(21):2758-73. PMID: 10557205.
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D'Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M, Curran T. Reelin is a ligand for lipoprotein receptors. Neuron. 1999 Oct; 24(2):471-9. PMID: 10571240.
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Homayouni R, Rice DS, Sheldon M, Curran T. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci. 1999 Sep 01; 19(17):7507-15. PMID: 10460257.
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Alvarez-Dolado M, Ruiz M, Del R?o JA, Alc?ntara S, Burgaya F, Sheldon M, Nakajima K, Bernal J, Howell BW, Curran T, Soriano E, Mu?oz A. Thyroid hormone regulates reelin and dab1 expression during brain development. J Neurosci. 1999 Aug 15; 19(16):6979-93. PMID: 10436054.
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Magdaleno SM, Curran T. Gene dosage in mice--BAC to the future. Nat Genet. 1999 Aug; 22(4):319-20. PMID: 10431229.
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Borrell V, Del R?o JA, Alc?ntara S, Derer M, Mart?nez A, D'Arcangelo G, Nakajima K, Mikoshiba K, Derer P, Curran T, Soriano E. Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections. J Neurosci. 1999 Feb 15; 19(4):1345-58. PMID: 9952412.
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Bakin AV, Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science. 1999 Jan 15; 283(5400):387-90. PMID: 9888853.
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Vendrell M, Curran T, Morgan JI. A gene expression approach to mapping the functional maturation of the hippocampus. Brain Res Mol Brain Res. 1998 Dec 10; 63(1):25-34. PMID: 9838029.
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Alc?ntara S, Ruiz M, D'Arcangelo G, Ezan F, de Lecea L, Curran T, Sotelo C, Soriano E. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. J Neurosci. 1998 Oct 01; 18(19):7779-99. PMID: 9742148.
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Curran T. c-fos and Signal Transduction In Vivo. Toxicol In Vitro. 1998 Oct; 12(5):523-4. PMID: 20654433.
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Barros AC, Erway LC, Krezel W, Curran T, Kastner P, Chambon P, Forrest D. Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis. Neuroreport. 1998 Sep 14; 9(13):2933-7. PMID: 9804293.
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Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 1998 Sep; 125(18):3719-29. PMID: 9716537.
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Eberhart DE, Curran T. Yayoi era mutation disrupts brain and muscle. Nat Med. 1998 Sep; 4(9):1002-3. PMID: 9734385.
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Curran T, D'Arcangelo G. Role of reelin in the control of brain development. Brain Res Brain Res Rev. 1998 May; 26(2-3):285-94. PMID: 9651544.
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D'Arcangelo G, Curran T. Reeler: new tales on an old mutant mouse. Bioessays. 1998 Mar; 20(3):235-44. PMID: 9631651.
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Goldowitz D, Cushing RC, Laywell E, D'Arcangelo G, Sheldon M, Sweet HO, Davisson M, Steindler D, Curran T. Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin. J Neurosci. 1997 Nov 15; 17(22):8767-77. PMID: 9348346.
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Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell BW, Cooper JA, Goldowitz D, Curran T. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 1997 Oct 16; 389(6652):730-3. PMID: 9338784.
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Weiss RE, Forrest D, Pohlenz J, Cua K, Curran T, Refetoff S. Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice. Endocrinology. 1997 Sep; 138(9):3624-9. PMID: 9275045.
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Kerppola TK, Curran T. The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J. 1997 May 15; 16(10):2907-16. PMID: 9184234.
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Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev. 1997 Mar 01; 11(5):558-70. PMID: 9119221.
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DeSilva U, D'Arcangelo G, Braden VV, Chen J, Miao GG, Curran T, Green ED. The human reelin gene: isolation, sequencing, and mapping on chromosome 7. Genome Res. 1997 Feb; 7(2):157-64. PMID: 9049633.
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D'Arcangelo G, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Curran T. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci. 1997 Jan 01; 17(1):23-31. PMID: 8987733.
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Ito K, Asano M, Hughes P, Kohzaki H, Masutani C, Hanaoka F, Kerppola T, Curran T, Murakami Y, Ito Y. c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large Tantigen. EMBO J. 1996 Oct 15; 15(20):5636-46. PMID: 8896457.
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Yuzaki M, Forrest D, Curran T, Connor JA. Selective activation of calcium permeability by aspartate in Purkinje cells. Science. 1996 Aug 23; 273(5278):1112-4. PMID: 8688099.
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Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8919-23. PMID: 8799128.
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Yuzaki M, Forrest D, Verselis LM, Sun SC, Curran T, Connor JA. Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture. J Neurosci. 1996 Aug 01; 16(15):4651-61. PMID: 8764653.
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Forrest D, Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet. 1996 Jul; 13(3):354-7. PMID: 8673137.
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D'Arcangelo G, Miao GG, Curran T. Detection of the reelin breakpoint in reeler mice. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):234-6. PMID: 8804731.
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Forrest D, Hanebuth E, Smeyne RJ, Everds N, Stewart CL, Wehner JM, Curran T. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. EMBO J. 1996 Jun 17; 15(12):3006-15. PMID: 8670802.
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Kasof GM, Smeyne RJ, Curran T, Morgan JI. Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats. Brain Res Dev Brain Res. 1996 May 31; 93(1-2):191-7. PMID: 8804706.
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Xanthoudakis S, Viola JP, Shaw KT, Luo C, Wallace JD, Bozza PT, Luk DC, Curran T, Rao A. An enhanced immune response in mice lacking the transcription factor NFAT1. Science. 1996 May 10; 272(5263):892-5. PMID: 8629027.
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Martin ML, Lieberman PM, Curran T. Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. Mol Cell Biol. 1996 May; 16(5):2110-8. PMID: 8628277.
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Chen RH, Juo PC, Curran T, Blenis J. Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene. 1996 Apr 04; 12(7):1493-502. PMID: 8622865.
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Hermida-Matsumoto ML, Chock PB, Curran T, Yang DC. Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes. J Biol Chem. 1996 Mar 01; 271(9):4930-6. PMID: 8617766.
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Xanthoudakis S, Curran T. Redox regulation of AP-1: a link between transcription factor signaling and DNA repair. Adv Exp Med Biol. 1996; 387:69-75. PMID: 8794196.
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Forrest D, Golarai G, Connor J, Curran T. Genetic analysis of thyroid hormone receptors in development and disease. Recent Prog Horm Res. 1996; 51:1-22. PMID: 8701076.
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Kasof GM, Mahanty NK, Pozzo Miller LD, Curran T, Connor JA, Morgan JI. Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats. Brain Res Mol Brain Res. 1995 Dec 28; 34(2):197-208. PMID: 8750823.
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Isaac VE, Patel L, Curran T, Abate-Shen C. Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain. Biochemistry. 1995 Nov 21; 34(46):15276-81. PMID: 7578143.
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Curran T, D'Arcangelo G, Goffinet A. Reeler gene discrepancies. Nat Genet. 1995 Sep; 11(1):12-3. PMID: 7550305.
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Ng L, Forrest D, Haugen BR, Wood WM, Curran T. N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone. Mol Endocrinol. 1995 Sep; 9(9):1202-13. PMID: 7491112.
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D'Arcangelo G, Curran T. Human genetics. Smart transcription factors. Nature. 1995 Jul 27; 376(6538):292-3. PMID: 7630390.
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Kasof GM, Mandelzys A, Maika SD, Hammer RE, Curran T, Morgan JI. Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J Neurosci. 1995 Jun; 15(6):4238-49. PMID: 7790908.
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D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995 Apr 20; 374(6524):719-23. PMID: 7715726.
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Curran T, Morgan JI. Fos: an immediate-early transcription factor in neurons. J Neurobiol. 1995 Mar; 26(3):403-12. PMID: 7775973.
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Robertson LM, Kerppola TK, Vendrell M, Luk D, Smeyne RJ, Bocchiaro C, Morgan JI, Curran T. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements. Neuron. 1995 Feb; 14(2):241-52. PMID: 7857636.
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Morgan JI, Curran T. Immediate-early genes: ten years on. Trends Neurosci. 1995 Feb; 18(2):66-7. PMID: 7537412.
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Kerppola T, Curran T. Transcription. Zen and the art of Fos and Jun. Nature. 1995 Jan 19; 373(6511):199-200. PMID: 7816132.
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Chen SC, Curran T, Morgan JI. Apoptosis in the nervous system: new revelations. J Clin Pathol. 1995 Jan; 48(1):7-12. PMID: 7706524.
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Morgan JI., Curran T. The Immediate-Early Gene Response and Neuronal Death and Regeneration. The Neuroscientist. 1995; 1(2):68-75.
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Soares HD, Curran T, Morgan JI. Transcription factors as molecular mediators in cell death. Ann N Y Acad Sci. 1994 Dec 15; 747:172-82. PMID: 7531406.
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Miao GG, Smeyne RJ, D'Arcangelo G, Copeland NG, Jenkins NA, Morgan JI, Curran T. Isolation of an allele of reeler by insertional mutagenesis. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):11050-4. PMID: 7972007.
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Kerppola TK, Curran T. A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins. Oncogene. 1994 Nov; 9(11):3149-58. PMID: 7936637.
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Yaseen NR, Park J, Kerppola T, Curran T, Sharma S. A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly. Mol Cell Biol. 1994 Oct; 14(10):6886-95. PMID: 7935406.
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Yao KS, Xanthoudakis S, Curran T, O'Dwyer PJ. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol. 1994 Sep; 14(9):5997-6003. PMID: 8065332.
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Shang Z, Isaac VE, Li H, Patel L, Catron KM, Curran T, Montelione GT, Abate C. Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8373-7. PMID: 7915838.
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Forrest D, Yuzaki M, Soares HD, Ng L, Luk DC, Sheng M, Stewart CL, Morgan JI, Connor JA, Curran T. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron. 1994 Aug; 13(2):325-38. PMID: 8060614.
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Patel LR, Curran T, Kerppola TK. Energy transfer analysis of Fos-Jun dimerization and DNA binding. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7360-4. PMID: 8041795.
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Miao GG, Curran T. Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle. Mol Cell Biol. 1994 Jun; 14(6):4295-310. PMID: 8196666.
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Kerppola TK, Curran T. Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene. 1994 Mar; 9(3):675-84. PMID: 8108109.
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Xanthoudakis S, Miao GG, Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):23-7. PMID: 7506414.
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Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol. 1994 Jan; 14(1):268-76. PMID: 8264594.
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Xanthoudakis S, Curran T. Analysis of c-Fos and c-Jun redox-dependent DNA binding activity. Methods Enzymol. 1994; 234:163-74. PMID: 7808290.
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Ascher P., Catterall WA, Curran T., Heinemann S., Jonas P., Kelly RB., Muller W., Seeburg PH., Selverston AI, Sudhof TC. In: Dahlem workshop on Cellular and Molecular Mechanisms Underlying Higher Neural Functions. (Eds. A.I. Selverston, P. Ascher). Group Report: What molecular mechanisms are likely to be central for plasticity in the operation of the nervous system? LW Role Rapporteur John Wiley & Sons, UK. 1994; 303-318.
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Ng L, Forrest D, Curran T. Differential roles for Fos and Jun in DNA-binding: redox-dependent and independent functions. Nucleic Acids Res. 1993 Dec 25; 21(25):5831-7. PMID: 8290340.
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McCaffrey PG, Luo C, Kerppola TK, Jain J, Badalian TM, Ho AM, Burgeon E, Lane WS, Lambert JN, Curran T, et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29; 262(5134):750-4. PMID: 8235597.
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Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature. 1993 Sep 23; 365(6444):352-5. PMID: 8397339.
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Kerppola TK, Curran T. Selective DNA bending by a variety of bZIP proteins. Mol Cell Biol. 1993 Sep; 13(9):5479-89. PMID: 8355695.
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Abate C, Baker SJ, Lees-Miller SP, Anderson CW, Marshak DR, Curran T. Dimerization and DNA binding alter phosphorylation of Fos and Jun. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6766-70. PMID: 8341696.
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Molinar-Rode R, Smeyne RJ, Curran T, Morgan JI. Regulation of proto-oncogene expression in adult and developing lungs. Mol Cell Biol. 1993 Jun; 13(6):3213-20. PMID: 8497249.
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Kerppola TK, Luk D, Curran T. Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro. Mol Cell Biol. 1993 Jun; 13(6):3782-91. PMID: 8497279.
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Vendrell M, Curran T, Morgan JI. Glutamate, immediate-early genes, and cell death in the nervous system. Ann N Y Acad Sci. 1993 May 28; 679:132-41. PMID: 8099770.
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Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GG, Schilling K, Robertson LM, Curran T, Morgan JI. Continuous c-fos expression precedes programmed cell death in vivo. Nature. 1993 May 13; 363(6425):166-9. PMID: 8483500.
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Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H. Escape from redox regulation enhances the transforming activity of Fos. Oncogene. 1993 Mar; 8(3):695-701. PMID: 8437852.
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Curran T, Abate C, Baker S, Kerppola T, Xanthoudakis S. The regulation of c-fos: too much is never enough. Adv Second Messenger Phosphoprotein Res. 1993; 28:271-7. PMID: 8398414.
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Smeyne RJ, Schilling K, Oberdick J, Robertson L, Luk D, Curran T, Morgan JI. A fos-lac Z transgenic mouse that can be used for neuroanatomic mapping. Adv Neurol. 1993; 59:285-91. PMID: 8420113.
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Hayward MD, Curran T, Morgan JI. Immediate early genes: their involvement in physiological and pathological responses in the nervous system. NIDA Res Monogr. 1993; 125:39-53. PMID: 8341368.
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Smeyne RJ, Curran T, Morgan JI. Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system. Brain Res Mol Brain Res. 1992 Nov; 16(1-2):158-62. PMID: 1334194.
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Curran T. Fos and Jun: oncogenic transcription factors. Tohoku J Exp Med. 1992 Oct; 168(2):169-74. PMID: 1306301.
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Baker SJ, Kerppola TK, Luk D, Vandenberg MT, Marshak DR, Curran T, Abate C. Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts. Mol Cell Biol. 1992 Oct; 12(10):4694-705. PMID: 1328860.
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Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 1992 Sep; 11(9):3323-35. PMID: 1380454.
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Xanthoudakis S, Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J. 1992 Feb; 11(2):653-65. PMID: 1537340.
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Forrest D, Curran T. Crossed signals: oncogenic transcription factors. Curr Opin Genet Dev. 1992 Feb; 2(1):19-27. PMID: 1633422.
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Smeyne RJ, Schilling K, Robertson L, Luk D, Oberdick J, Curran T, Morgan JI. fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system. Neuron. 1992 Jan; 8(1):13-23. PMID: 1730004.
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Abate C, Marshak DR, Curran T. Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions. Oncogene. 1991 Dec; 6(12):2179-85. PMID: 1766667.
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Kerppola TK, Curran T. DNA bending by Fos and Jun: the flexible hinge model. Science. 1991 Nov 22; 254(5035):1210-4. PMID: 1957173.
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Okuno H, Suzuki T, Yoshida T, Hashimoto Y, Curran T, Iba H. Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene. Oncogene. 1991 Sep; 6(9):1491-7. PMID: 1923517.
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Morgan JI, Curran T. Proto-oncogene transcription factors and epilepsy. Trends Pharmacol Sci. 1991 Sep; 12(9):343-9. PMID: 1949203.
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Alvarez E, Northwood IC, Gonzalez FA, Latour DA, Seth A, Abate C, Curran T, Davis RJ. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J Biol Chem. 1991 Aug 15; 266(23):15277-85. PMID: 1651323.
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Kerppola TK, Curran T. Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell. 1991 Jul 26; 66(2):317-26. PMID: 1906785.
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Abate C, Luk D, Curran T. Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains. Mol Cell Biol. 1991 Jul; 11(7):3624-32. PMID: 1904542.
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Schilling K, Luk D, Morgan JI, Curran T. Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling. Proc Natl Acad Sci U S A. 1991 Jul 01; 88(13):5665-9. PMID: 1648227.
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Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3720-4. PMID: 1827203.
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Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci. 1991; 14:421-51. PMID: 1903243.
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Schilling K, Curran T, Morgan JI. Fosvergn?gen. The excitement of immediate-early genes. Ann N Y Acad Sci. 1991; 627:115-23. PMID: 1909106.
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Brugge J, Curran, Harlow E, McCormick F. Origins of Human Cancer: A Comprehensive Review. Cold Spring Harbor Laboratory Press. 1991.
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Owen TA, Bortell R, Yocum SA, Smock SL, Zhang M, Abate C, Shalhoub V, Aronin N, Wright KL, van Wijnen AJ, et al. Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9990-4. PMID: 2124710.
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Rauscher FJ, Morris JF, Tournay OE, Cook DM, Curran T. Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence. Science. 1990 Nov 30; 250(4985):1259-62. PMID: 2244209.
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Patel L, Abate C, Curran T. Altered protein conformation on DNA binding by Fos and Jun. Nature. 1990 Oct 11; 347(6293):572-5. PMID: 2120592.
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Abate C, Luk D, Gagne E, Roeder RG, Curran T. Fos and jun cooperate in transcriptional regulation via heterologous activation domains. Mol Cell Biol. 1990 Oct; 10(10):5532-5. PMID: 2119000.
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Abate C, Luk D, Curran T. A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly. Cell Growth Differ. 1990 Oct; 1(10):455-62. PMID: 2126189.
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Abate C, Patel L, Rauscher FJ, Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science. 1990 Sep 07; 249(4973):1157-61. PMID: 2118682.
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Shin C, McNamara JO, Morgan JI, Curran T, Cohen DR. Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J Neurochem. 1990 Sep; 55(3):1050-5. PMID: 2117045.
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Gius D, Cao XM, Rauscher FJ, Cohen DR, Curran T, Sukhatme VP. Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol Cell Biol. 1990 Aug; 10(8):4243-55. PMID: 2115122.
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Cohen DR, Curran T. Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region. Oncogene. 1990 Jun; 5(6):929-39. PMID: 2113670.
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Macgregor PF, Abate C, Curran T. Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1. Oncogene. 1990 Apr; 5(4):451-8. PMID: 2139203.
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Abate C, Curran T. Encounters with Fos and Jun on the road to AP-1. Semin Cancer Biol. 1990 Feb; 1(1):19-26. PMID: 2133107.
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Abate C, Luk D, Gentz R, Rauscher FJ, Curran T. Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):1032-6. PMID: 2105492.
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Morgan JI, Curran T. Inducible proto-oncogenes of the nervous system: their contribution to transcription factors and neuroplasticity. Prog Brain Res. 1990; 86:287-94. PMID: 2128418.
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Curran T, Abate C, Cohen DR, Macgregor PF, Rauscher FJ, Sonnenberg JL, Connor JA, Morgan JI. Inducible proto-oncogene transcription factors: third messengers in the brain? Cold Spring Harb Symp Quant Biol. 1990; 55:225-34. PMID: 2132816.
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Sonnenberg JL, Rauscher FJ, Morgan JI, Curran T. Regulation of proenkephalin by Fos and Jun. Science. 1989 Dec 22; 246(4937):1622-5. PMID: 2512642.
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Curran T. Nobel oncogenes. New Biol. 1989 Dec; 1(3):229-31. PMID: 2487288.
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Morgan JI, Curran T. Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. Trends Neurosci. 1989 Nov; 12(11):459-62. PMID: 2479148.
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Sonnenberg JL, Mitchelmore C, Macgregor-Leon PF, Hempstead J, Morgan JI, Curran T. Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain. J Neurosci Res. 1989 Sep; 24(1):72-80. PMID: 2553994.
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Sonnenberg JL, Macgregor-Leon PF, Curran T, Morgan JI. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron. 1989 Sep; 3(3):359-65. PMID: 2518370.
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Gentz R, Rauscher FJ, Abate C, Curran T. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science. 1989 Mar 31; 243(4899):1695-9. PMID: 2494702.
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Cohen DR, Ferreira PC, Gentz R, Franza BR, Curran T. The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 1989 Feb; 3(2):173-84. PMID: 2497053.
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Bos TJ, Rauscher FJ, Curran T, Vogt PK. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene. 1989 Feb; 4(2):123-6. PMID: 2494630.
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Morgan JI, Curran T. Calcium and proto-oncogene involvement in the immediate-early response in the nervous system. Ann N Y Acad Sci. 1989; 568:283-90. PMID: 2516994.
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Cohen DR, Curran T. The structure and function of the fos proto-oncogene. Crit Rev Oncog. 1989; 1(1):65-88. PMID: 2518683.
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Mugnaini E, Berrebi AS, Morgan JI, Curran T. Fos-Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With Euchromatin in Neurons. Eur J Neurosci. 1989 Jan; 1(1):46-52. PMID: 12106173.
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Rauscher FJ, Voulalas PJ, Franza BR, Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 1988 Dec; 2(12B):1687-99. PMID: 2467839.
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Morgan JI, Curran T. Calcium as a modulator of the immediate-early gene cascade in neurons. Cell Calcium. 1988 Dec; 9(5-6):303-11. PMID: 3147142.
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Lee WM, Lin C, Curran T. Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein. Mol Cell Biol. 1988 Dec; 8(12):5521-7. PMID: 3149716.
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Curran T, Franza BR. Fos and Jun: the AP-1 connection. Cell. 1988 Nov 04; 55(3):395-7. PMID: 3141060.
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Kousvelari E, Louis JM, Huang LH, Curran T. Regulation of proto-oncogenes in rat parotid acinar cells in vitro after stimulation of beta-adrenergic receptors. Exp Cell Res. 1988 Nov; 179(1):194-203. PMID: 2844568.
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Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science. 1988 Jun 03; 240(4857):1328-31. PMID: 3131879.
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Rauscher FJ, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza BR. Fos-associated protein p39 is the product of the jun proto-oncogene. Science. 1988 May 20; 240(4855):1010-6. PMID: 3130660.
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Cohen DR, Curran T. fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen. Mol Cell Biol. 1988 May; 8(5):2063-9. PMID: 3133553.
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Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988 Apr 08; 53(1):37-43. PMID: 3127059.
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Franza BR, Rauscher FJ, Josephs SF, Curran T. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science. 1988 Mar 04; 239(4844):1150-3. PMID: 2964084.
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Rauscher FJ, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM. Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell. 1988 Feb 12; 52(3):471-80. PMID: 3125983.
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Curran T, Rauscher FJ, Cohen DR, Franza BR. Beyond the second messenger: oncogenes and transcription factors. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:769-77. PMID: 3076095.
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Reddy EP, Skalka AM, Curran T. The Oncogene Handbook. Elsevier, Amsterdam. 1988.
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Curran T, Morgan JI. Memories of fos. Bioessays. 1987 Dec; 7(6):255-8. PMID: 3124834.
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Pompidou A, Corral M, Michel P, Defer N, Kruh J, Curran T. The effects of phorbol ester and Ca ionophore on c-fos and c-myc expression and on DNA synthesis in human lymphocytes are not directly related. Biochem Biophys Res Commun. 1987 Oct 14; 148(1):435-42. PMID: 3118872.
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O'Hara BM, Klinger HP, Curran T, Zhang YD, Blair DG. Levels of fos, ets2, and myb proto-oncogene RNAs correlate with segregation of chromosome 11 of normal cells and with suppression of tumorigenicity in human cell hybrids. Mol Cell Biol. 1987 Aug; 7(8):2941-6. PMID: 3670301.
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Morgan JI, Cohen DR, Hempstead JL, Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 1987 Jul 10; 237(4811):192-7. PMID: 3037702.
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Franza BR, Sambucetti LC, Cohen DR, Curran T. Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis. Oncogene. 1987 May; 1(2):213-21. PMID: 3325882.
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Curran T, Gordon MB, Rubino KL, Sambucetti LC. Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro. Oncogene. 1987; 2(1):79-84. PMID: 3325886.
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Stacey DW, Watson T, Kung HF, Curran T. Microinjection of transforming ras protein induces c-fos expression. Mol Cell Biol. 1987 Jan; 7(1):523-7. PMID: 3104768.
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Sambucetti LC, Curran T. The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. Science. 1986 Dec 12; 234(4782):1417-9. PMID: 3491427.
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Curran T, Morgan JI. Barium modulates c-fos expression and post-translational modification. Proc Natl Acad Sci U S A. 1986 Nov; 83(22):8521-4. PMID: 2430291.
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Morgan JI, Curran T. Role of ion flux in the control of c-fos expression. Nature. 1986 Aug 7-13; 322(6079):552-5. PMID: 2426600.
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Bravo R, Burckhardt J, Curran T, M?ller R. Expression of c-fos in NIH3T3 cells is very low but inducible throughout the cell cycle. EMBO J. 1986 Apr; 5(4):695-700. PMID: 3709522.
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Sambucetti LC, Schaber M, Kramer R, Crowl R, Curran T. The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells. Gene. 1986; 43(1-2):69-77. PMID: 3019839.
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Pompidou A, Corral M, Michel P, Kruh J, Curran T. [Stimulation of human lymphocytes by phorbol acetate and a calcium ionophore induces an early transient expression of the c-fos oncogene followed by c-myc]. C R Acad Sci III. 1986; 303(11):445-7. PMID: 3096504.
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Curran T, Morgan JI. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science. 1985 Sep 20; 229(4719):1265-8. PMID: 4035354.
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Miller AD, Verma IM, Curran T. Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity. J Virol. 1985 Sep; 55(3):521-6. PMID: 2991577.
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Meijlink F, Curran T, Miller AD, Verma IM. Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. Proc Natl Acad Sci U S A. 1985 Aug; 82(15):4987-91. PMID: 2991903.
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Jenuwein T, M?ller D, Curran T, M?ller R. Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV. Cell. 1985 Jun; 41(2):629-37. PMID: 2985286.
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Bravo R, Burckhardt J, Curran T, M?ller R. Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes. EMBO J. 1985 May; 4(5):1193-7. PMID: 3159569.
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M?ller R, Curran T, M?ller D, Guilbert L. Induction of c-fos during myelomonocytic differentiation and macrophage proliferation. Nature. 1985 Apr 11-17; 314(6011):546-8. PMID: 3887183.
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Curran T, Bravo R, M?ller R. Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation. Cancer Surv. 1985; 4(4):655-81. PMID: 3939686.
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Curran T, Van Beveren C, Verma IM. Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein. Mol Cell Biol. 1985 Jan; 5(1):167-72. PMID: 3885008.
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M?ller R, Bravo R, Burckhardt J, Curran T. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature. 1984 Dec 20-1985 Jan 2; 312(5996):716-20. PMID: 6334806.
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Curran T, Verma IM. FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product. Virology. 1984 May; 135(1):218-28. PMID: 6203214.
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Van Beveren C, Enami S, Curran T, Verma IM. FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes. Virology. 1984 May; 135(1):229-43. PMID: 6203215.
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Curran T, Miller AD, Zokas L, Verma IM. Viral and cellular fos proteins: a comparative analysis. Cell. 1984 Feb; 36(2):259-68. PMID: 6319013.
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Miller AD, Curran T, Verma IM. c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell. 1984 Jan; 36(1):51-60. PMID: 6607118.
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van Straaten F, M?ller R, Curran T, Van Beveren C, Verma IM. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3183-7. PMID: 6574479.
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Curran T, MacConnell WP, van Straaten F, Verma IM. Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells. Mol Cell Biol. 1983 May; 3(5):914-21. PMID: 6306448.
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Van Beveren C, van Straaten F, Curran T, M?ller R, Verma IM. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell. 1983 Apr; 32(4):1241-55. PMID: 6301687.
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Curran T, Peters G, Van Beveren C, Teich NM, Verma IM. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J Virol. 1982 Nov; 44(2):674-82. PMID: 6292525.
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Curran T, Teich NM. Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein. J Virol. 1982 Apr; 42(1):114-22. PMID: 6283132.
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Curran T. Studies on the FBJ murine osteosarcoma virus complex. Ph.D. thesis,. 1982.
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Curran T, Teich NM. Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus. Virology. 1982 Jan 15; 116(1):221-35. PMID: 6278709.
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Orlowski M, Karkowsky A. Glutathione metabolism and some possible functions of glutathione in the nervous system. Int Rev Neurobiol. 1976; 19:75-121. PMID: 13046.
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Thanassi JW. Reactions of aminomalononitrile with electrophiles. J Mol Evol. 1975 Dec 31; 7(1):65-73. PMID: 2786.
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Sanchez G, Alderete JF. The effect of host adrenalectomy on the physiology of Trypanosoma rhodesiense. Comp Biochem Physiol A Comp Physiol. 1975 Dec 01; 52(4):623-6. PMID: 1186.
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Flohr H, Breull W. Effect of etafenone on total and regional myocardial blood flow. Arzneimittelforschung. 1975 Sep; 25(9):1400-3. PMID: 23.
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Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
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1993 | 13 | 1994 | 14 | 1995 | 13 | 1996 | 14 | 1997 | 7 | 1998 | 8 | 1999 | 7 | 2000 | 5 | 2001 | 8 | 2002 | 8 | 2003 | 10 | 2004 | 6 | 2005 | 6 | 2006 | 8 | 2007 | 3 | 2008 | 5 | 2009 | 2 | 2010 | 6 | 2011 | 4 | 2012 | 3 | 2013 | 3 | 2014 | 3 | 2015 | 5 | 2016 | 3 | 2017 | 1 | 2018 | 3 | 2019 | 1 | 2020 | 1 | 2021 | 4 | 2022 | 2 | 2023 | 3 |
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