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Tom Curran, PhD, FRS

TitleSenior Vice President, Executive Director and Chief Scientific Officer, Children's Research Institute
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0003-1444-7551 Additional info
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    Other Positions
    TitleDonald J. Hall Eminent Scholar in Pediatric Research
    InstitutionChildren's Mercy Kansas City
    DepartmentChildren's Research Institute

    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleResearch Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentCancer Biology

    TitleAdjunct Professor of Biomedical Sciences
    InstitutionKansas City University of Medicine & Biosciences
    DepartmentBiomedical Sciences


    Collapse Biography 
    Collapse education and training
    Imperial Cancer Research Fund Laboratories and University College London, London, UKPhD1982Zoology and Anatomy
    Salk Institute, San Diego, CAFellowship1984
    Edinburgh University, ScotlandBSc (Hons 1st class)1978Biological Sciences (Zoology)
    Collapse awards and honors
    1978Ashworth Prize in Zoology, Edinburgh University
    1992Tenovus-Scotland Medal, Glasgow University
    1992Young Scientist Award, Passano Foundation
    1992Rita Levi Montalcini Award in Neurosciences, Fidia Foundation
    1993Outstanding Achievement in Cancer Research, American Association for Cancer Research
    1994Fellow, American Association for Advancement of Science
    1994Golgi Award, Italian Academy of Neurosciences
    1994Fellow, American Academy of Microbiology
    2000President, American Association for Cancer Research
    2005Fellow, Royal Society, London
    2009Member, National Academy of Medicine
    2012Fellow, American Academy of Arts & Sciences
    2013Fellow, AACR Academy
    2015Fred Epstein Lifetime Achievement Award, Children's Brain Tumor Foundation
    2020Fellow, Royal Society of Edinburgh

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 290 papers that have been cited more than 50,000 times.

    Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Park T, Curran T. Requirement for Crk and CrkL during postnatal lens development. Biochem Biophys Res Commun. 2020 Aug 27; 529(3):603-607. PMID: 32736680.
      View in: PubMed
    2. Du F, Yuelling L, Lee EH, Wang Y, Liao S, Cheng Y, Zhang L, Zheng C, Peri S, Cai KQ, Ng JMY, Curran T, Li P, Yang ZJ. Leukotriene Synthesis Is Critical for Medulloblastoma Progression. Clin Cancer Res. 2019 11 01; 25(21):6475-6486. PMID: 31300449.
      View in: PubMed
    3. Curran T. Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer. Open Biol. 2018 08; 8(8). PMID: 30068568.
      View in: PubMed
    4. Gordon RE, Zhang L, Peri S, Kuo YM, Du F, Egleston BL, Ng JMY, Andrews AJ, Astsaturov I, Curran T, Yang ZJ. Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. Clin Cancer Res. 2018 03 15; 24(6):1375-1388. PMID: 29437795.
      View in: PubMed
    5. Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X. Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 01 23; 7. PMID: 29360039.
      View in: PubMed
    6. Liu Y, Yuelling LW, Wang Y, Du F, Gordon RE, O'Brien JA, Ng JMY, Robins S, Lee EH, Liu H, Curran T, Yang ZJ. Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion. Cancer Res. 2017 12 01; 77(23):6692-6703. PMID: 28986380.
      View in: PubMed
    7. Park T, Koptyra M, Curran T. Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL). J Biol Chem. 2016 Dec 16; 291(51):26273-26290. PMID: 27807028.
      View in: PubMed
    8. Li P, Lee EH, Du F, Gordon RE, Yuelling LW, Liu Y, Ng JM, Zhang H, Wu J, Korshunov A, Pfister SM, Curran T, Yang ZJ. Nestin Mediates Hedgehog Pathway Tumorigenesis. Cancer Res. 2016 09 15; 76(18):5573-83. PMID: 27496710.
      View in: PubMed
    9. Melo FM, Couto PP, Bale AE, Bastos-Rodrigues L, Passos FM, Lisboa RG, Ng JM, Curran T, Dias EP, Friedman E, De Marco L. Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma. Cancer Genet. 2016 06; 209(6):251-7. PMID: 27245436.
      View in: PubMed
    10. Ng JM, Martinez D, Marsh ED, Zhang Z, Rappaport E, Santi M, Curran T. Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53. Cancer Res. 2015 Nov 01; 75(21):4629-39. PMID: 26363008.
      View in: PubMed
    11. Dang MT, Wehrli S, Dang CV, Curran T. The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice. PLoS One. 2015; 10(7):e0133633. PMID: 26192445.
      View in: PubMed
    12. Robinson GW, Orr BA, Wu G, Gururangan S, Lin T, Qaddoumi I, Packer RJ, Goldman S, Prados MD, Desjardins A, Chintagumpala M, Takebe N, Kaste SC, Rusch M, Allen SJ, Onar-Thomas A, Stewart CF, Fouladi M, Boyett JM, Gilbertson RJ, Curran T, Ellison DW, Gajjar A. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. J Clin Oncol. 2015 Aug 20; 33(24):2646-54. PMID: 26169613.
      View in: PubMed
    13. Huang Y, Clarke F, Karimi M, Roy NH, Williamson EK, Okumura M, Mochizuki K, Chen EJ, Park TJ, Debes GF, Zhang Y, Curran T, Kambayashi T, Burkhardt JK. CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest. 2015 Mar 02; 125(3):1019-32. PMID: 25621495.
      View in: PubMed
    14. Koptyra M, Park TJ, Curran T. Crk and CrkL are required for cell transformation by v-fos and v-ras. Mol Carcinog. 2016 Jan; 55(1):97-104. PMID: 25557916.
      View in: PubMed
    15. Park TJ, Curran T. Neurobiology: Reelin mediates form and function. Curr Biol. 2014 Nov 17; 24(22):R1089-92. PMID: 25458219.
      View in: PubMed
    16. Kim J, Park TJ, Kwon N, Lee D, Kim S, Kohmura Y, Ishikawa T, Kim KT, Curran T, Je JH. Dendritic planarity of Purkinje cells is independent of Reelin signaling. Brain Struct Funct. 2015 Jul; 220(4):2263-73. PMID: 24828132.
      View in: PubMed
    17. George B, Fan Q, Dlugos CP, Soofi AA, Zhang J, Verma R, Park TJ, Wong H, Curran T, Nihalani D, Holzman LB. Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis. Kidney Int. 2014 Jun; 85(6):1382-1394. PMID: 24499776.
      View in: PubMed
    18. Park TJ, Curran T. Essential roles of Crk and CrkL in fibroblast structure and motility. Oncogene. 2014 Oct 23; 33(43):5121-32. PMID: 24166500.
      View in: PubMed
    19. Gajjar A, Stewart CF, Ellison DW, Kaste S, Kun LE, Packer RJ, Goldman S, Chintagumpala M, Wallace D, Takebe N, Boyett JM, Gilbertson RJ, Curran T. Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clin Cancer Res. 2013 Nov 15; 19(22):6305-12. PMID: 24077351.
      View in: PubMed
    20. Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Res. 2013 Apr 15; 73(8):2650-8. PMID: 23580576.
      View in: PubMed
    21. Wang Y, Davidow L, Arvanites AC, Blanchard J, Lam K, Xu K, Oza V, Yoo JW, Ng JM, Curran T, Rubin LL, McMahon AP. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012 Aug 24; 19(8):972-82. PMID: 22921064.
      View in: PubMed
    22. Curran T. Q&A: Tom Curran on translational research. Cancer Discov. 2012 Feb; 2(2):99. PMID: 22585839.
      View in: PubMed
    23. George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb; 122(2):674-92. PMID: 22251701.
      View in: PubMed
    24. Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA. The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. Nat Cell Biol. 2011 Dec 18; 14(1):87-92. PMID: 22179045.
      View in: PubMed
    25. Tom Curran. Deconstructing the Mosaic Brain. The Scientist. LabX Media Group. 2011; 25(6):26-27.
    26. Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer. 2011 May 26; 11(7):493-501. PMID: 21614026.
      View in: PubMed
    27. Brechbiel JL, Ng JM, Curran T. PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice. Toxicol Pathol. 2011 Apr; 39(3):478-85. PMID: 21411723.
      View in: PubMed
    28. Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9. PMID: 21163964.
      View in: PubMed
    29. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61. PMID: 20978073.
      View in: PubMed
    30. Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ. Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes Dev. 2010 Nov 01; 24(21):2451-61. PMID: 21041412.
      View in: PubMed
    31. Curran T. Mouse models and mouse supermodels. EMBO Mol Med. 2010 Oct; 2(10):385-6; author reply 386-7. PMID: 20721989.
      View in: PubMed
    32. Park TJ, Curran T. Alternative splicing disabled by Nova2. Neuron. 2010 Jun 24; 66(6):811-3. PMID: 20620865.
      View in: PubMed
    33. T. Curran, Y. Christen (Eds). Two Faces of Evil: Cancer and Neurodegeneration, Research Perspectives in Alzheimer's Disease. Foundation IPSEN. Springer. 2010.
    34. Yip YP, Mehta N, Magdaleno S, Curran T, Yip JW. Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord. J Comp Neurol. 2009 Jul 10; 515(2):260-8. PMID: 19412957.
      View in: PubMed
    35. Ng L, Ma M, Curran T, Forrest D. Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse. Neuroreport. 2009 Apr 22; 20(6):627-31. PMID: 19282790.
      View in: PubMed
    36. Park TJ, Curran T. Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci. 2008 Dec 10; 28(50):13551-62. PMID: 19074029.
      View in: PubMed
    37. Curran T, Ng JM. Cancer: Hedgehog's other great trick. Nature. 2008 Sep 18; 455(7211):293-4. PMID: 18800119.
      View in: PubMed
    38. De Gasperi R, Gama Sosa MA, Wen PH, Li J, Perez GM, Curran T, Elder GA. Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. Dev Dyn. 2008 Sep; 237(9):2405-14. PMID: 18729224.
      View in: PubMed
    39. Kimura H, Ng JM, Curran T. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell. 2008 Mar; 13(3):249-60. PMID: 18328428.
      View in: PubMed
    40. Thomas Curran. The road to Osaka. The 20th Anniversary of the OSAKA Bioscience Institute Commemorative Publication. 2008; 97-99.
    41. Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol. 2007 Oct; 27(19):6706-17. PMID: 17646384.
      View in: PubMed
    42. Lee Y, Kawagoe R, Sasai K, Li Y, Russell HR, Curran T, McKinnon PJ. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene. 2007 Sep 27; 26(44):6442-7. PMID: 17452975.
      View in: PubMed
    43. Sasai K, Romer JT, Kimura H, Eberhart DE, Rice DS, Curran T. Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Cancer Res. 2007 Apr 15; 67(8):3871-7. PMID: 17413002.
      View in: PubMed
    44. Park TJ, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol. 2006 Aug; 26(16):6272-82. PMID: 16880535.
      View in: PubMed
    45. Lee Y, Miller HL, Russell HR, Boyd K, Curran T, McKinnon PJ. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 2006 Jul 15; 66(14):6964-71. PMID: 16849540.
      View in: PubMed
    46. Liu J, Wang J, Huang Q, Higdon J, Magdaleno S, Curran T, Zuo J. Gene expression profiles of mouse retinas during the second and third postnatal weeks. Brain Res. 2006 Jul 07; 1098(1):113-25. PMID: 16777074.
      View in: PubMed
    47. Brumwell CL, Curran T. Developmental mouse brain gene expression maps. J Physiol. 2006 Sep 01; 575(Pt 2):343-6. PMID: 16728446.
      View in: PubMed
    48. Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, Curran T. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res. 2006 Apr 15; 66(8):4215-22. PMID: 16618744.
      View in: PubMed
    49. Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr; 4(4):e86. PMID: 16602821.
      View in: PubMed
    50. Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006 Apr 20; 24(12):1924-31. PMID: 16567768.
      View in: PubMed
    51. Dellovade T, Romer JT, Curran T, Rubin LL. The hedgehog pathway and neurological disorders. Annu Rev Neurosci. 2006; 29:539-63. PMID: 16776596.
      View in: PubMed
    52. Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 2005 Nov 15; 19(22):2656-67. PMID: 16260494.
      View in: PubMed
    53. Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdaleno S, Dalton J, Calabrese C, Board J, Macdonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell. 2005 Oct; 8(4):323-35. PMID: 16226707.
      View in: PubMed
    54. Curran T. Lost in translation: the future of cancer research? Clin Cancer Res. 2005 Jul 01; 11(13):4644-5. PMID: 16000555.
      View in: PubMed
    55. Romer J, Curran T. Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res. 2005 Jun 15; 65(12):4975-8. PMID: 15958535.
      View in: PubMed
    56. Kimura H, Stephen D, Joyner A, Curran T. Gli1 is important for medulloblastoma formation in Ptc1+/- mice. Oncogene. 2005 Jun 09; 24(25):4026-36. PMID: 15806168.
      View in: PubMed
    57. Ordway JM, Fenster SD, Ruan H, Curran T. A transcriptome map of cellular transformation by the fos oncogene. Mol Cancer. 2005 May 26; 4(1):19. PMID: 15918904.
      View in: PubMed
    58. Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T. A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20; 132(2):116-27. PMID: 15582152.
      View in: PubMed
    59. Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran T. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell. 2004 Sep; 6(3):229-40. PMID: 15380514.
      View in: PubMed
    60. Romer JT, Curran T. Medulloblastoma and retinoblastoma: oncology recapitulates ontogeny. Cell Cycle. 2004 Jul; 3(7):917-9. PMID: 15254429.
      View in: PubMed
    61. Huang Y, Magdaleno S, Hopkins R, Slaughter C, Curran T, Keshvara L. Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins. Biochem Biophys Res Commun. 2004 May 21; 318(1):204-12. PMID: 15110774.
      View in: PubMed
    62. Ordway JM, Williams K, Curran T. Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene. 2004 May 06; 23(21):3737-48. PMID: 14990994.
      View in: PubMed
    63. Yip YP, Capriotti C, Magdaleno S, Benhayon D, Curran T, Nakajima K, Yip JW. Components of the reelin signaling pathway are expressed in the spinal cord. J Comp Neurol. 2004 Mar 01; 470(2):210-9. PMID: 14750162.
      View in: PubMed
    64. Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel MF, Curran T, Gilbertson RJ, McKinnon PJ. A molecular fingerprint for medulloblastoma. Cancer Res. 2003 Sep 01; 63(17):5428-37. PMID: 14500378.
      View in: PubMed
    65. Andersen OM, Benhayon D, Curran T, Willnow TE. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003 Aug 12; 42(31):9355-64. PMID: 12899622.
      View in: PubMed
    66. Homayouni R, Magdaleno S, Keshvara L, Rice DS, Curran T. Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res. 2003 Jul 23; 115(2):121-9. PMID: 12877983.
      View in: PubMed
    67. Curran T. From bings to biology: taking a different path in cancer research. Cancer Biol Ther. 2003 Jul-Aug; 2(4):456-9. PMID: 14508121.
      View in: PubMed
    68. Yun M, Keshvara L, Park CG, Zhang YM, Dickerson JB, Zheng J, Rock CO, Curran T, Park HW. Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem. 2003 Sep 19; 278(38):36572-81. PMID: 12826668.
      View in: PubMed
    69. Yang WQ, Senger D, Muzik H, Shi ZQ, Johnson D, Brasher PM, Rewcastle NB, Hamilton M, Rutka J, Wolff J, Wetmore C, Curran T, Lee PW, Forsyth PA. Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma. Cancer Res. 2003 Jun 15; 63(12):3162-72. PMID: 12810644.
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    70. Ordway JM, Eberhart D, Curran T. Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding. Mol Cell Biol. 2003 Jun; 23(12):4257-66. PMID: 12773568.
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    71. Li L, Connelly MC, Wetmore C, Curran T, Morgan JI. Mouse embryos cloned from brain tumors. Cancer Res. 2003 Jun 01; 63(11):2733-6. PMID: 12782575.
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    72. Benhayon D, Magdaleno S, Curran T. Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Brain Res Mol Brain Res. 2003 Apr 10; 112(1-2):33-45. PMID: 12670700.
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    73. Joseph V. Simone, MD, Bruce W. Stillman, PhD, Ellen Stovall, Diana Petitti, MD, Jill Bargonetti, PhD, Barry Bozeman, PhD, Tim Byers, MD, MPH, Tom Curran, PhD, Timothy Eberlein, MD, David Galas, PhD, Karen Hersey, JD, Daniel J. Kevles, PhD, Lauren Linton, PhD, MBA, William W. McGuire, MD, John Mendelsohn, MD, Kathleen H. Mooney, PhD, Nancy Mueller, ScD, Patricia A. Nolan, MD, MPH, Cecil B. Pickett, PhD, Stephen Prescott, MD, Louise B. Russell, PhD, Thomas J. Smith, MD, FACP, Susan Weiner, PhD, Robert C. Young, MD. Large-Scale Biomedical Science Exploring Strategies For Future Research Sc. The National Academies Press. Committee on Large-Scale Science and Cancer Research Sharyl J. Nass and Bruce W. Stillman (eds.). The National Academies Press. 2003.
    74. Gilbertson RJ, Bentley L, Hernan R, Junttila TT, Frank AJ, Haapasalo H, Connelly M, Wetmore C, Curran T, Elenius K, Ellison DW. ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clin Cancer Res. 2002 Oct; 8(10):3054-64. PMID: 12374672.
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    75. Magdaleno S, Northcutt GM, Curran T, Kurschner C. mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain. Brain Res Gene Expr Patterns. 2002 Oct; 1(3-4):143-9. PMID: 12638124.
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    76. Keshvara L, Magdaleno S, Benhayon D, Curran T. Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J Neurosci. 2002 Jun 15; 22(12):4869-77. PMID: 12077184.
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    77. Ordway JM, Curran T. Methylation matters: modeling a manageable genome. Cell Growth Differ. 2002 Apr; 13(4):149-62. PMID: 11971815.
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    78. Magdaleno S, Keshvara L, Curran T. Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron. 2002 Feb 14; 33(4):573-86. PMID: 11856531.
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    79. Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 2002 Jan 24; 415(6870):436-42. PMID: 11807556.
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    80. Curran T.: Fos. In: Encyclopedia of Cancer, 2nd Edition (J. R. Bertino, Ed.). Academic Press, San Diego. 2002; 2:243-248.
    81. Keshvara L, Magdaleno S, Benhayon D. Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. USA Patent Number US20020172990 A1. 2002.
    82. Magdaleno SM, Curran T. Brain development: integrins and the Reelin pathway. Curr Biol. 2001 Dec 11; 11(24):R1032-5. PMID: 11747842.
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    83. Homayouni R, Rice DS, Curran T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem Biophys Res Commun. 2001 Nov 30; 289(2):539-47. PMID: 11716507.
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    84. Rice DS, Nusinowitz S, Azimi AM, Martínez A, Soriano E, Curran T. The reelin pathway modulates the structure and function of retinal synaptic circuitry. Neuron. 2001 Sep 27; 31(6):929-41. PMID: 11580894.
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    85. Ng L, Pedraza PE, Faris JS, Vennström B, Curran T, Morreale de Escobar G, Forrest D. Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice. Neuroreport. 2001 Aug 08; 12(11):2359-62. PMID: 11496110.
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    86. Keshvara L, Benhayon D, Magdaleno S, Curran T. Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J Biol Chem. 2001 May 11; 276(19):16008-14. PMID: 11279201.
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    87. Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 2001 Jan 15; 61(2):513-6. PMID: 11212243.
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    91. Bernier B, Bar I, D'Arcangelo G, Curran T, Goffinet AM. Reelin mRNA expression during embryonic brain development in the chick. J Comp Neurol. 2000 Jul 03; 422(3):448-63. PMID: 10861519.
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    92. Homayouni R, Curran T. Cortical development: Cdk5 gets into sticky situations. Curr Biol. 2000 May 04; 10(9):R331-4. PMID: 10801432.
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    93. Wetmore C, Eberhart DE, Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res. 2000 Apr 15; 60(8):2239-46. PMID: 10786690.
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    94. Single FN, Rozov A, Burnashev N, Zimmermann F, Hanley DF, Forrest D, Curran T, Jensen V, Hvalby O, Sprengel R, Seeburg PH. Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R). J Neurosci. 2000 Apr 01; 20(7):2558-66. PMID: 10729336.
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    95. Rice DS, Curran T. Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev. 1999 Nov 01; 13(21):2758-73. PMID: 10557205.
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    96. D'Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M, Curran T. Reelin is a ligand for lipoprotein receptors. Neuron. 1999 Oct; 24(2):471-9. PMID: 10571240.
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    97. Homayouni R, Rice DS, Sheldon M, Curran T. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci. 1999 Sep 01; 19(17):7507-15. PMID: 10460257.
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    98. Alvarez-Dolado M, Ruiz M, Del Río JA, Alcántara S, Burgaya F, Sheldon M, Nakajima K, Bernal J, Howell BW, Curran T, Soriano E, Muñoz A. Thyroid hormone regulates reelin and dab1 expression during brain development. J Neurosci. 1999 Aug 15; 19(16):6979-93. PMID: 10436054.
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    99. Magdaleno SM, Curran T. Gene dosage in mice--BAC to the future. Nat Genet. 1999 Aug; 22(4):319-20. PMID: 10431229.
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    101. Bakin AV, Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science. 1999 Jan 15; 283(5400):387-90. PMID: 9888853.
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    102. Vendrell M, Curran T, Morgan JI. A gene expression approach to mapping the functional maturation of the hippocampus. Brain Res Mol Brain Res. 1998 Dec 10; 63(1):25-34. PMID: 9838029.
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    103. Alcántara S, Ruiz M, D'Arcangelo G, Ezan F, de Lecea L, Curran T, Sotelo C, Soriano E. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. J Neurosci. 1998 Oct 01; 18(19):7779-99. PMID: 9742148.
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    105. Barros AC, Erway LC, Krezel W, Curran T, Kastner P, Chambon P, Forrest D. Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis. Neuroreport. 1998 Sep 14; 9(13):2933-7. PMID: 9804293.
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    106. Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 1998 Sep; 125(18):3719-29. PMID: 9716537.
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    107. Eberhart DE, Curran T. Yayoi era mutation disrupts brain and muscle. Nat Med. 1998 Sep; 4(9):1002-3. PMID: 9734385.
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    108. Curran T, D'Arcangelo G. Role of reelin in the control of brain development. Brain Res Brain Res Rev. 1998 May; 26(2-3):285-94. PMID: 9651544.
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    109. D'Arcangelo G, Curran T. Reeler: new tales on an old mutant mouse. Bioessays. 1998 Mar; 20(3):235-44. PMID: 9631651.
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    111. Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell BW, Cooper JA, Goldowitz D, Curran T. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 1997 Oct 16; 389(6652):730-3. PMID: 9338784.
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    112. Weiss RE, Forrest D, Pohlenz J, Cua K, Curran T, Refetoff S. Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice. Endocrinology. 1997 Sep; 138(9):3624-9. PMID: 9275045.
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    113. Kerppola TK, Curran T. The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J. 1997 May 15; 16(10):2907-16. PMID: 9184234.
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    114. Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev. 1997 Mar 01; 11(5):558-70. PMID: 9119221.
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    115. DeSilva U, D'Arcangelo G, Braden VV, Chen J, Miao GG, Curran T, Green ED. The human reelin gene: isolation, sequencing, and mapping on chromosome 7. Genome Res. 1997 Feb; 7(2):157-64. PMID: 9049633.
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    116. D'Arcangelo G, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Curran T. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci. 1997 Jan 01; 17(1):23-31. PMID: 8987733.
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    117. Ito K, Asano M, Hughes P, Kohzaki H, Masutani C, Hanaoka F, Kerppola T, Curran T, Murakami Y, Ito Y. c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large Tantigen. EMBO J. 1996 Oct 15; 15(20):5636-46. PMID: 8896457.
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    118. Yuzaki M, Forrest D, Curran T, Connor JA. Selective activation of calcium permeability by aspartate in Purkinje cells. Science. 1996 Aug 23; 273(5278):1112-4. PMID: 8688099.
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    121. Forrest D, Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet. 1996 Jul; 13(3):354-7. PMID: 8673137.
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    122. D'Arcangelo G, Miao GG, Curran T. Detection of the reelin breakpoint in reeler mice. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):234-6. PMID: 8804731.
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    123. Forrest D, Hanebuth E, Smeyne RJ, Everds N, Stewart CL, Wehner JM, Curran T. Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. EMBO J. 1996 Jun 17; 15(12):3006-15. PMID: 8670802.
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    124. Kasof GM, Smeyne RJ, Curran T, Morgan JI. Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats. Brain Res Dev Brain Res. 1996 May 31; 93(1-2):191-7. PMID: 8804706.
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    125. Xanthoudakis S, Viola JP, Shaw KT, Luo C, Wallace JD, Bozza PT, Luk DC, Curran T, Rao A. An enhanced immune response in mice lacking the transcription factor NFAT1. Science. 1996 May 10; 272(5263):892-5. PMID: 8629027.
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    127. Chen RH, Juo PC, Curran T, Blenis J. Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene. 1996 Apr 04; 12(7):1493-502. PMID: 8622865.
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    128. Hermida-Matsumoto ML, Chock PB, Curran T, Yang DC. Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes. J Biol Chem. 1996 Mar 01; 271(9):4930-6. PMID: 8617766.
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    129. Xanthoudakis S, Curran T. Redox regulation of AP-1: a link between transcription factor signaling and DNA repair. Adv Exp Med Biol. 1996; 387:69-75. PMID: 8794196.
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    131. Kasof GM, Mahanty NK, Pozzo Miller LD, Curran T, Connor JA, Morgan JI. Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats. Brain Res Mol Brain Res. 1995 Dec 28; 34(2):197-208. PMID: 8750823.
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    132. Isaac VE, Patel L, Curran T, Abate-Shen C. Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain. Biochemistry. 1995 Nov 21; 34(46):15276-81. PMID: 7578143.
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    133. Curran T, D'Arcangelo G, Goffinet A. Reeler gene discrepancies. Nat Genet. 1995 Sep; 11(1):12-3. PMID: 7550305.
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    134. Ng L, Forrest D, Haugen BR, Wood WM, Curran T. N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone. Mol Endocrinol. 1995 Sep; 9(9):1202-13. PMID: 7491112.
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    135. D'Arcangelo G, Curran T. Human genetics. Smart transcription factors. Nature. 1995 Jul 27; 376(6538):292-3. PMID: 7630390.
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    137. D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995 Apr 20; 374(6524):719-23. PMID: 7715726.
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    138. Curran T, Morgan JI. Fos: an immediate-early transcription factor in neurons. J Neurobiol. 1995 Mar; 26(3):403-12. PMID: 7775973.
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    140. Morgan JI, Curran T. Immediate-early genes: ten years on. Trends Neurosci. 1995 Feb; 18(2):66-7. PMID: 7537412.
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    142. Chen SC, Curran T, Morgan JI. Apoptosis in the nervous system: new revelations. J Clin Pathol. 1995 Jan; 48(1):7-12. PMID: 7706524.
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    146. Kerppola TK, Curran T. A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins. Oncogene. 1994 Nov; 9(11):3149-58. PMID: 7936637.
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    147. Yaseen NR, Park J, Kerppola T, Curran T, Sharma S. A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly. Mol Cell Biol. 1994 Oct; 14(10):6886-95. PMID: 7935406.
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    148. Yao KS, Xanthoudakis S, Curran T, O'Dwyer PJ. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol. 1994 Sep; 14(9):5997-6003. PMID: 8065332.
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    150. Forrest D, Yuzaki M, Soares HD, Ng L, Luk DC, Sheng M, Stewart CL, Morgan JI, Connor JA, Curran T. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron. 1994 Aug; 13(2):325-38. PMID: 8060614.
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    155. Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol. 1994 Jan; 14(1):268-76. PMID: 8264594.
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    157. Ascher P., Catterall WA, Curran T., Heinemann S., Jonas P., Kelly RB., Muller W., Seeburg PH., Selverston AI, Sudhof TC. In: Dahlem workshop on Cellular and Molecular Mechanisms Underlying Higher Neural Functions. (Eds. A.I. Selverston, P. Ascher). Group Report: What molecular mechanisms are likely to be central for plasticity in the operation of the nervous system? LW Role Rapporteur John Wiley & Sons, UK. 1994; 303-318.
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    159. McCaffrey PG, Luo C, Kerppola TK, Jain J, Badalian TM, Ho AM, Burgeon E, Lane WS, Lambert JN, Curran T, et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29; 262(5134):750-4. PMID: 8235597.
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    161. Kerppola TK, Curran T. Selective DNA bending by a variety of bZIP proteins. Mol Cell Biol. 1993 Sep; 13(9):5479-89. PMID: 8355695.
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    163. Molinar-Rode R, Smeyne RJ, Curran T, Morgan JI. Regulation of proto-oncogene expression in adult and developing lungs. Mol Cell Biol. 1993 Jun; 13(6):3213-20. PMID: 8497249.
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    165. Vendrell M, Curran T, Morgan JI. Glutamate, immediate-early genes, and cell death in the nervous system. Ann N Y Acad Sci. 1993 May 28; 679:132-41. PMID: 8099770.
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    176. Forrest D, Curran T. Crossed signals: oncogenic transcription factors. Curr Opin Genet Dev. 1992 Feb; 2(1):19-27. PMID: 1633422.
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    194. Abate C, Luk D, Curran T. A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly. Cell Growth Differ. 1990 Oct; 1(10):455-62. PMID: 2126189.
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    195. Abate C, Patel L, Rauscher FJ, Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science. 1990 Sep 07; 249(4973):1157-61. PMID: 2118682.
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    196. Shin C, McNamara JO, Morgan JI, Curran T, Cohen DR. Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J Neurochem. 1990 Sep; 55(3):1050-5. PMID: 2117045.
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    197. Gius D, Cao XM, Rauscher FJ, Cohen DR, Curran T, Sukhatme VP. Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol Cell Biol. 1990 Aug; 10(8):4243-55. PMID: 2115122.
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    198. Cohen DR, Curran T. Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region. Oncogene. 1990 Jun; 5(6):929-39. PMID: 2113670.
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    199. Macgregor PF, Abate C, Curran T. Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1. Oncogene. 1990 Apr; 5(4):451-8. PMID: 2139203.
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    200. Abate C, Curran T. Encounters with Fos and Jun on the road to AP-1. Semin Cancer Biol. 1990 Feb; 1(1):19-26. PMID: 2133107.
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    201. Abate C, Luk D, Gentz R, Rauscher FJ, Curran T. Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):1032-6. PMID: 2105492.
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    202. Morgan JI, Curran T. Inducible proto-oncogenes of the nervous system: their contribution to transcription factors and neuroplasticity. Prog Brain Res. 1990; 86:287-94. PMID: 2128418.
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    203. Curran T, Abate C, Cohen DR, Macgregor PF, Rauscher FJ, Sonnenberg JL, Connor JA, Morgan JI. Inducible proto-oncogene transcription factors: third messengers in the brain? Cold Spring Harb Symp Quant Biol. 1990; 55:225-34. PMID: 2132816.
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    204. Sonnenberg JL, Rauscher FJ, Morgan JI, Curran T. Regulation of proenkephalin by Fos and Jun. Science. 1989 Dec 22; 246(4937):1622-5. PMID: 2512642.
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    205. Curran T. Nobel oncogenes. New Biol. 1989 Dec; 1(3):229-31. PMID: 2487288.
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    206. Morgan JI, Curran T. Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. Trends Neurosci. 1989 Nov; 12(11):459-62. PMID: 2479148.
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    207. Sonnenberg JL, Mitchelmore C, Macgregor-Leon PF, Hempstead J, Morgan JI, Curran T. Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain. J Neurosci Res. 1989 Sep; 24(1):72-80. PMID: 2553994.
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    208. Sonnenberg JL, Macgregor-Leon PF, Curran T, Morgan JI. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron. 1989 Sep; 3(3):359-65. PMID: 2518370.
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    209. Gentz R, Rauscher FJ, Abate C, Curran T. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science. 1989 Mar 31; 243(4899):1695-9. PMID: 2494702.
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    210. Cohen DR, Ferreira PC, Gentz R, Franza BR, Curran T. The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 1989 Feb; 3(2):173-84. PMID: 2497053.
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    211. Bos TJ, Rauscher FJ, Curran T, Vogt PK. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene. 1989 Feb; 4(2):123-6. PMID: 2494630.
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    212. Morgan JI, Curran T. Calcium and proto-oncogene involvement in the immediate-early response in the nervous system. Ann N Y Acad Sci. 1989; 568:283-90. PMID: 2516994.
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    213. Cohen DR, Curran T. The structure and function of the fos proto-oncogene. Crit Rev Oncog. 1989; 1(1):65-88. PMID: 2518683.
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    214. Mugnaini E, Berrebi AS, Morgan JI, Curran T. Fos-Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With Euchromatin in Neurons. Eur J Neurosci. 1989 Jan; 1(1):46-52. PMID: 12106173.
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    215. Rauscher FJ, Voulalas PJ, Franza BR, Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 1988 Dec; 2(12B):1687-99. PMID: 2467839.
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    216. Morgan JI, Curran T. Calcium as a modulator of the immediate-early gene cascade in neurons. Cell Calcium. 1988 Dec; 9(5-6):303-11. PMID: 3147142.
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    217. Lee WM, Lin C, Curran T. Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein. Mol Cell Biol. 1988 Dec; 8(12):5521-7. PMID: 3149716.
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    218. Curran T, Franza BR. Fos and Jun: the AP-1 connection. Cell. 1988 Nov 04; 55(3):395-7. PMID: 3141060.
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    219. Kousvelari E, Louis JM, Huang LH, Curran T. Regulation of proto-oncogenes in rat parotid acinar cells in vitro after stimulation of beta-adrenergic receptors. Exp Cell Res. 1988 Nov; 179(1):194-203. PMID: 2844568.
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    220. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science. 1988 Jun 03; 240(4857):1328-31. PMID: 3131879.
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    221. Rauscher FJ, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza BR. Fos-associated protein p39 is the product of the jun proto-oncogene. Science. 1988 May 20; 240(4855):1010-6. PMID: 3130660.
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    222. Cohen DR, Curran T. fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen. Mol Cell Biol. 1988 May; 8(5):2063-9. PMID: 3133553.
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    223. Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988 Apr 08; 53(1):37-43. PMID: 3127059.
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    224. Franza BR, Rauscher FJ, Josephs SF, Curran T. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science. 1988 Mar 04; 239(4844):1150-3. PMID: 2964084.
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    225. Rauscher FJ, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM. Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell. 1988 Feb 12; 52(3):471-80. PMID: 3125983.
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    226. Curran T, Rauscher FJ, Cohen DR, Franza BR. Beyond the second messenger: oncogenes and transcription factors. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:769-77. PMID: 3076095.
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    227. Reddy EP, Skalka AM, Curran T. The Oncogene Handbook. Elsevier, Amsterdam. 1988.
    228. Curran T, Morgan JI. Memories of fos. Bioessays. 1987 Dec; 7(6):255-8. PMID: 3124834.
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    229. Pompidou A, Corral M, Michel P, Defer N, Kruh J, Curran T. The effects of phorbol ester and Ca ionophore on c-fos and c-myc expression and on DNA synthesis in human lymphocytes are not directly related. Biochem Biophys Res Commun. 1987 Oct 14; 148(1):435-42. PMID: 3118872.
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    230. O'Hara BM, Klinger HP, Curran T, Zhang YD, Blair DG. Levels of fos, ets2, and myb proto-oncogene RNAs correlate with segregation of chromosome 11 of normal cells and with suppression of tumorigenicity in human cell hybrids. Mol Cell Biol. 1987 Aug; 7(8):2941-6. PMID: 3670301.
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    231. Morgan JI, Cohen DR, Hempstead JL, Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 1987 Jul 10; 237(4811):192-7. PMID: 3037702.
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    232. Franza BR, Sambucetti LC, Cohen DR, Curran T. Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis. Oncogene. 1987 May; 1(2):213-21. PMID: 3325882.
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    233. Curran T, Gordon MB, Rubino KL, Sambucetti LC. Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro. Oncogene. 1987; 2(1):79-84. PMID: 3325886.
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    234. Stacey DW, Watson T, Kung HF, Curran T. Microinjection of transforming ras protein induces c-fos expression. Mol Cell Biol. 1987 Jan; 7(1):523-7. PMID: 3104768.
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    235. Sambucetti LC, Curran T. The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. Science. 1986 Dec 12; 234(4782):1417-9. PMID: 3491427.
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    236. Curran T, Morgan JI. Barium modulates c-fos expression and post-translational modification. Proc Natl Acad Sci U S A. 1986 Nov; 83(22):8521-4. PMID: 2430291.
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    237. Morgan JI, Curran T. Role of ion flux in the control of c-fos expression. Nature. 1986 Aug 7-13; 322(6079):552-5. PMID: 2426600.
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    238. Bravo R, Burckhardt J, Curran T, Müller R. Expression of c-fos in NIH3T3 cells is very low but inducible throughout the cell cycle. EMBO J. 1986 Apr; 5(4):695-700. PMID: 3709522.
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    239. Sambucetti LC, Schaber M, Kramer R, Crowl R, Curran T. The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells. Gene. 1986; 43(1-2):69-77. PMID: 3019839.
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    240. Pompidou A, Corral M, Michel P, Kruh J, Curran T. [Stimulation of human lymphocytes by phorbol acetate and a calcium ionophore induces an early transient expression of the c-fos oncogene followed by c-myc]. C R Acad Sci III. 1986; 303(11):445-7. PMID: 3096504.
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    241. Curran T, Morgan JI. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science. 1985 Sep 20; 229(4719):1265-8. PMID: 4035354.
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    242. Miller AD, Verma IM, Curran T. Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity. J Virol. 1985 Sep; 55(3):521-6. PMID: 2991577.
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    243. Meijlink F, Curran T, Miller AD, Verma IM. Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. Proc Natl Acad Sci U S A. 1985 Aug; 82(15):4987-91. PMID: 2991903.
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    244. Jenuwein T, Müller D, Curran T, Müller R. Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV. Cell. 1985 Jun; 41(2):629-37. PMID: 2985286.
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    245. Bravo R, Burckhardt J, Curran T, Müller R. Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes. EMBO J. 1985 May; 4(5):1193-7. PMID: 3159569.
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    246. Müller R, Curran T, Müller D, Guilbert L. Induction of c-fos during myelomonocytic differentiation and macrophage proliferation. Nature. 1985 Apr 11-17; 314(6011):546-8. PMID: 3887183.
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    247. Curran T, Bravo R, Müller R. Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation. Cancer Surv. 1985; 4(4):655-81. PMID: 3939686.
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    248. Curran T, Van Beveren C, Verma IM. Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein. Mol Cell Biol. 1985 Jan; 5(1):167-72. PMID: 3885008.
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    249. Müller R, Bravo R, Burckhardt J, Curran T. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature. 1984 Dec 20-1985 Jan 2; 312(5996):716-20. PMID: 6334806.
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    250. Curran T, Verma IM. FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product. Virology. 1984 May; 135(1):218-28. PMID: 6203214.
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    251. Van Beveren C, Enami S, Curran T, Verma IM. FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes. Virology. 1984 May; 135(1):229-43. PMID: 6203215.
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    252. Curran T, Miller AD, Zokas L, Verma IM. Viral and cellular fos proteins: a comparative analysis. Cell. 1984 Feb; 36(2):259-68. PMID: 6319013.
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    253. Miller AD, Curran T, Verma IM. c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell. 1984 Jan; 36(1):51-60. PMID: 6607118.
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    254. van Straaten F, Müller R, Curran T, Van Beveren C, Verma IM. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3183-7. PMID: 6574479.
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    255. Curran T, MacConnell WP, van Straaten F, Verma IM. Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells. Mol Cell Biol. 1983 May; 3(5):914-21. PMID: 6306448.
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    256. Van Beveren C, van Straaten F, Curran T, Müller R, Verma IM. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell. 1983 Apr; 32(4):1241-55. PMID: 6301687.
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    257. Curran T, Peters G, Van Beveren C, Teich NM, Verma IM. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J Virol. 1982 Nov; 44(2):674-82. PMID: 6292525.
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    258. Curran T, Teich NM. Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein. J Virol. 1982 Apr; 42(1):114-22. PMID: 6283132.
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    259. Curran T. Studies on the FBJ murine osteosarcoma virus complex. Ph.D. thesis,. 1982.
    260. Curran T, Teich NM. Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus. Virology. 1982 Jan 15; 116(1):221-35. PMID: 6278709.
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