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Sean Riordan, PhD

TitleResearch Assistant Professor
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0001-5727-1221 Additional info
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    Other Positions
    TitleResearch Assistant Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleResearch Assistant Professor of Neurology
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    William Jewell College, Liberty, MO2006Molecular Biology
    Northwestern University, Evanston, ILPhD2013Neurobiology
    Children's Mercy Hospital, Kansas City, MOFellowship2015Translational Genetics

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    The overarching goal of Dr. Riordan's lab is to improve the care and treatment of the severely jaundiced infant and to help develop novel therapies for those patients suffering from the lifelong disability caused by bilirubin neurotoxicity, aka kernicterus. First, the lab aims to improve the preventative treatment standards of severe hyperbilirubinemia by through the use of genetic screening for markers of bilirubin sensitivity. The development of a genetic screen for bilirubin sensitivity will lead to a reduction of unnecessarily aggressive treatment for some severely jaundiced babies while providing hypervigilance for others. Second, the lab aims to develop stem cell treatment methodologies aimed at replacing specific cell populations in the globus pallidus of the kernicteric brain. The hope is that these treatments will normal signaling of the basal ganglia motor loop, which is thought to be the cause of secondary dystonia due to kernicterus.
    Collapse research activities and funding
         (Sean Riordan)Oct 31, 2019
    BioNexus KC Patton Trust Research Grant
    The genetic response to neurotoxic bilirubin in jaundiced rats before and after administration of bilirubin-displacing drugs
    Role Description: The goal of this project is to define the genetic response to bilirubin neurotoxicity in vivo in the classic jaundiced Gunn rat model of hyperbilirubinemia and kernicterus. The long-term objective is to discover actionable genetic targets that could augment current methods to improve treatment of severe newborn jaundice and prevent kernicterus.
    Role: Principal Investigator

         (Sean Riordan)Jan 1, 2016 - Jan 1, 2017
    Children’s Mercy Hospital Center for Pediatric Genomic Medicine Pilot Grant
    Understanding Complex Outcomes with Pathway Genetic Load Analysis: Key Epistatic Interactions in Bilrubin Encephalopathy
    Role Description: The goal of this study is to perform a pilot study to investigate whether a modified pathway genetic load score method can predict whether a person will be more sensitive to bilirubin neurotoxicity as a child.
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gazzin S, Riordan SM. Commentary on the Don Ostrow Trieste Yellow Retreat 2019: a successful biennium, what next? Pediatr Res. 2020 Jan 18. PMID: 31954375.
      View in: PubMed
    2. Riordan SM, Shapiro SM. Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease. Pediatr Res. 2020 01; 87(2):327-331. PMID: 31600770.
      View in: PubMed
    3. Shapiro SM, Riordan SM. Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders. Pediatr Res. 2020 01; 87(2):332-337. PMID: 31581172.
      View in: PubMed
    4. Riordan SM, Gazzin S. Where do we stand in the field of neonatal jaundice? Commentary on the 2017 J. Donald Ostrow Trieste Yellow Retreat. Pediatr Res. 2018 06; 83(6):1090-1092. PMID: 29718006.
      View in: PubMed
    5. Zhang LQ, Nsumu M, Huang P, Heruth DP, Riordan SM, Shortt K, Zhang N, Grigoryev DN, Li DY, Friesen CA, Van Haandel L, Leeder JS, Olson J, Ye SQ. Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice. Am J Pathol. 2018 07; 188(7):1640-1652. PMID: 29684358.
      View in: PubMed
    6. Yang FC, Riordan SM, Winter M, Gan L, Smith PG, Vivian JL, Shapiro SM, Stanford JA. Fate of Neural Progenitor Cells Transplanted Into Jaundiced and Nonjaundiced Rat Brains. Cell Transplant. 2017 04 13; 26(4):605-611. PMID: 28155818.
      View in: PubMed
    7. Le Pichon JB, Riordan SM, Watchko J, Shapiro SM. The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs). Curr Pediatr Rev. 2017; 13(3):199-209. PMID: 28814249.
      View in: PubMed
    8. Riordan SM, Bittel DC, Le Pichon JB, Gazzin S, Tiribelli C, Watchko JF, Wennberg RP, Shapiro SM. A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy. Front Neurosci. 2016; 10:376. PMID: 27587993.
      View in: PubMed
    9. Riordan SM, Heruth DP, Zhang LQ, Ye SQ. Application of CRISPR/Cas9 for biomedical discoveries. Cell Biosci. 2015; 5:33. PMID: 26137216.
      View in: PubMed
    10. Huang P, Riordan SM, Heruth DP, Grigoryev DN, Zhang LQ, Ye SQ. A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells. Oncotarget. 2015 May 10; 6(13):10812-24. PMID: 25926556.
      View in: PubMed
    11. Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A. Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus. J Neurosci. 2015 Apr 22; 35(16):6544-53. PMID: 25904804.
      View in: PubMed
    12. Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener. 2014 Jan 04; 9:1. PMID: 24386896.
      View in: PubMed
    13. Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R. ß-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J Biol Chem. 2012 Nov 09; 287(46):38408-25. PMID: 22988240.
      View in: PubMed
    14. Youmans KL, Tai LM, Kanekiyo T, Stine WB, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ. Intraneuronal Aß detection in 5xFAD mice by a new Aß-specific antibody. Mol Neurodegener. 2012 Mar 16; 7:8. PMID: 22423893.
      View in: PubMed
    15. Miao H, Chen L, Riordan SM, Li W, Juarez S, Crabb AM, Lukas TJ, Du P, Lin SM, Wise A, Agapova OA, Yang P, Gu CC, Hernandez MR. Gene expression and functional studies of the optic nerve head astrocyte transcriptome from normal African Americans and Caucasian Americans donors. PLoS One. 2008 Aug 06; 3(8):e2847. PMID: 18716680.
      View in: PubMed
    16. Lukas TJ, Miao H, Chen L, Riordan SM, Li W, Crabb AM, Wise A, Du P, Lin SM, Hernandez MR. Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors. Genome Biol. 2008; 9(7):R111. PMID: 18613964.
      View in: PubMed
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