 Proton Pump Inhibitors
"Proton Pump Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
| Descriptor ID |
D054328
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| MeSH Number(s) |
D27.505.519.389.848
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proton Pump Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Proton Pump Inhibitors".
This graph shows the total number of publications written about "Proton Pump Inhibitors" by people in this website by year, and whether "Proton Pump Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proton Pump Inhibitors" by people in Profiles.
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Kyler KE, Gaedigk A, Abdel-Rahman S, Staggs VS, Pearce RE, Toren P, Leeder JS, Shakhnovich V. Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children. Clin Transl Sci. 2024 04; 17(4):e13782.
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Chevalier R, Attard T, Van Driest SL, Shakhnovich V. A fresh look at proton pump inhibitor (PPI)-associated adverse events through a CYP2C19 pharmacogenetic lens. Expert Opin Drug Metab Toxicol. 2023 02; 19(2):53-56.
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Feldman K, Kearns GL, Pearce RE, Abdel-Rahman SM, Steven Leeder J, Friesen A, Staggs VS, Gaedigk A, Weigel J, Shakhnovich V. Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children. Clin Transl Sci. 2022 05; 15(5):1155-1166.
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Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. Clin Pharmacol Ther. 2021 06; 109(6):1417-1423.
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Fleishman N, Richardson T, Attard T. The Clinical Characteristics of Fractures in Pediatric Patients Exposed to Proton Pump Inhibitors. J Pediatr Gastroenterol Nutr. 2020 06; 70(6):815-819.
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Kemper C, Haney B, Oschman A, Lee BR, Lyman B, Parker L, Brandon D. Acidity of Enteral Feeding Tube Aspirate in Neonates: Do pH Values Meet the Cutoff for Predicting Gastric Placement? Adv Neonatal Care. 2019 Aug; 19(4):333-341.
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Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. Paediatr Drugs. 2018 Oct; 20(5):483-495.
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Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL. Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity. Pediatr Obes. 2019 01; 14(1).
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Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. J Pediatr. 2018 02; 193:102-108.e1.
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Thomas PG, Sharp NE, Schnell K, Snyder CL, St Peter SD. The Role of Medication in Spontaneous Gastrocutaneous Fistula Closure. Eur J Pediatr Surg. 2015 Oct; 25(5):405-8.
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