 Chromatin Immunoprecipitation
"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
| Descriptor ID |
D047369
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| MeSH Number(s) |
E05.393.170 E05.478.605.160
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chromatin Immunoprecipitation".
Below are MeSH descriptors whose meaning is more specific than "Chromatin Immunoprecipitation".
This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in this website by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 3 | 3 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromatin Immunoprecipitation" by people in Profiles.
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Tao F, Rhonda E, He X, Perry JM, Li L. An optimized chromatin immunoprecipitation protocol using Staph-seq for analyzing genome-wide protein-DNA interactions. STAR Protoc. 2022 12 16; 3(4):101918.
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Anand S, Kalesinskas L, Smail C, Tanigawa Y. SNPs2ChIP: Latent Factors of ChIP-seq to infer functions of non-coding SNPs. Pac Symp Biocomput. 2019; 24:184-195.
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Hocking TD, Goerner-Potvin P, Morin A, Shao X, Pastinen T, Bourque G. Optimizing ChIP-seq peak detectors using visual labels and supervised machine learning. Bioinformatics. 2017 02 15; 33(4):491-499.
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Renaud SJ, Chakraborty D, Mason CW, Rumi MA, Vivian JL, Soares MJ. OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6175-84.
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Light N, Adoue V, Ge B, Chen SH, Kwan T, Pastinen T. Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping. Epigenetics. 2014 Sep; 9(9):1238-51.
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Schober ME, Ke X, Xing B, Block BP, Requena DF, McKnight R, Lane RH. Traumatic brain injury increased IGF-1B mRNA and altered IGF-1 exon 5 and promoter region epigenetic characteristics in the rat pup hippocampus. J Neurotrauma. 2012 Jul 20; 29(11):2075-85.
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Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, Lane RH, Desai M. Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1023-9.
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O'Grady SP, Caprau D, Ke XR, Contreras Y, Haley S, Ermini F, Penn A, Moyer-Mileur L, McKnight R, Lane R. Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. Syst Biol Reprod Med. 2010 Aug; 56(4):292-302.
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Ke X, Schober ME, McKnight RA, O'Grady S, Caprau D, Yu X, Callaway CW, Lane RH. Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene. Physiol Genomics. 2010 Jul 07; 42(2):177-89.
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Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol. 2008 Aug; 41(2):91-102.
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