11-beta-Hydroxysteroid Dehydrogenase Type 2
"11-beta-Hydroxysteroid Dehydrogenase Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
| Descriptor ID |
D043209
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| MeSH Number(s) |
D08.811.682.047.436.174.600 D08.811.682.047.820.100.600
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| Concept/Terms |
11-beta-Hydroxysteroid Dehydrogenase Type 2- 11-beta-Hydroxysteroid Dehydrogenase Type 2
- 11 beta Hydroxysteroid Dehydrogenase Type 2
- 11beta-Hydroxysteroid Dehydrogenase Type 2
- 11beta Hydroxysteroid Dehydrogenase Type 2
- 11beta-HSD2
- 11beta-HSD2 Reductase
- 11 beta-HSD2
- 11 beta-Hydroxysteroid Dehydrogenase Type 2
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Below are MeSH descriptors whose meaning is more general than "11-beta-Hydroxysteroid Dehydrogenase Type 2".
Below are MeSH descriptors whose meaning is more specific than "11-beta-Hydroxysteroid Dehydrogenase Type 2".
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Below are the most recent publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 2" by people in Profiles.
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Baserga M, Kaur R, Hale MA, Bares A, Yu X, Callaway CW, McKnight RA, Lane RH. Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R334-42.
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Baserga M, Hale MA, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. Am J Physiol Regul Integr Comp Physiol. 2007 May; 292(5):R1943-55.