 Amino Acid Substitution
"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
| Descriptor ID |
D019943
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| MeSH Number(s) |
E05.393.420.601.035 G05.355.600.109
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| Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
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Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
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Ranjan A, Iwakuma T. Emerging Non-Canonical Functions and Regulation of p53. Int J Mol Sci. 2018 Mar 28; 19(4).
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Jay AM, Conway RL, Thiffault I, Saunders C, Farrow E, Adams J, Toriello HV. Neonatal progeriod syndrome associated with biallelic truncating variants in POLR3A. . 2016 12; 170(12):3343-3346.
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Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF. Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. EBioMedicine. 2016 Oct; 12:196-207.
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Clinkenbeard EL, Farrow EG, Summers LJ, Cass TA, Roberts JL, Bayt CA, Lahm T, Albrecht M, Allen MR, Peacock M, White KE. Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice. J Bone Miner Res. 2014 Feb; 29(2):361-9.
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Liu P, Li H, Cepeda J, Zhang LQ, Cui X, Garcia JG, Ye SQ. Critical role of PBEF expression in pulmonary cell inflammation and permeability. Cell Biol Int. 2009 Jan; 33(1):19-30.
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Rogan PK, Svojanovsky S, Leeder JS. Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations. Pharmacogenetics. 2003 Apr; 13(4):207-18.
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Vivian JL, Chen Y, Yee D, Schneider E, Magnuson T. An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15542-7.
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