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William Truog, MD

TitleDirector of the Center of Infant Pulmonary Disorders
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitlePhysician
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleSosland Chair in Neonatal Research
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Chicago Pritzker School of Medicine, Chicago, IL MD1973
    Children's Hospital and University of Washington Medical Center, Seattle, WAResidency1976Pediatrics
    Children's Hospital and University of Washington Medical Center, Seattle, WAFellowship1978Neonatal/Perinatal Medicine

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    In 1993, Dr. Truog was recruited to Children’s Mercy-Kansas City/University of Missouri Kansas City School of Medicine as the Hospital’s first Physician Scientist, a then new position created to recruit productive physician scholars to Kansas City to expand the focus of the Hospital’s mission by integrating translational and clinical research into clinical practice. During his tenure in Kansas City, Dr. Truog has continued his research on pulmonary disorders, with greater emphasis on clinical research, including phase 2 and phase 3 clinical trials and outcomes-based research on critically ill newborns. This work has been supported by multiple federal grants including from both the NHLBI and the NICHD, and by other external competitive awards, with funding totaling ~$5,500,000 since 2000. Dr Truog has served as the Principal Investigator for the Children’s Mercy-Kansas City/University of Kansas site of the NIH Neonatal Research Network and a member of that organization’s steering committee. Participating on planning, executive and steering committees of multiple multi-center clinical trials has given Dr. Truog expertise in the benefits and pitfalls of prospective clinical research. Dr. Truog has planned and participated in pivotal multicenter trials testing the roles of high frequency ventilation, of inhaled nitric oxide in term and preterm infants, and of steroid treatment for amelioration of BPD.
    Collapse research activities and funding
    K04HL001205     (TRUOG, WILLIAM E)Jul 1, 1984 - Jun 30, 1989
    NIH/NHLBI
    VA/Q CHANGES IN NEONATAL LUNG DISEASES
    Role: Principal Investigator

    R01HL058125     (TRUOG, WILLIAM E)Apr 1, 1997 - Mar 31, 1999
    NIH/NHLBI
    INFLAMED LUNG AND NITRIC OXIDE--A SAFE COMBINATION?
    Role: Principal Investigator

    R01HL070560     (TRUOG, WILLIAM E)Feb 10, 2002 - Jan 31, 2008
    NIH/NHLBI
    TLR's, Nitric Oxide and Chronic Lung Disease
    Role: Principal Investigator

    U10HD068284     (TRUOG, WILLIAM E)Apr 10, 2011 - Mar 31, 2016
    NIH/NICHD
    The Children's Mercy-Truman-UMKC Center: A New Addition for the Next 5 Years
    Role: Principal Investigator

    UG1HD068284     (TRUOG, WILLIAM E)Apr 10, 2011 - Mar 31, 2018
    NIH/NICHD
    One Center, Two States
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McKinney RL, Keszler M, Truog WE, Norberg M, Sindelar R, Wallström L, Schulman B, Gien J, Abman SH. Multicenter Experience with Neurally Adjusted Ventilatory Assist in Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2020 Mar 24. PMID: 32208500.
      View in: PubMed
    2. Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2020 Jan; 40(1):149-156. PMID: 31570799.
      View in: PubMed
    3. Lewis T, Chalise P, Gauldin C, Truog W. Pharmacometabolomics of Respiratory Phenotypic Response to Dexamethasone in Preterm Infants at Risk for Bronchopulmonary Dysplasia. Clin Transl Sci. 2019 11; 12(6):591-599. PMID: 31188532.
      View in: PubMed
    4. Linafelter A, Cuna A, Liu C, Quigley A, Truog WE, Sampath V, Oschman A. Extended course of prednisolone in infants with severe bronchopulmonary dysplasia. Early Hum Dev. 2019 09; 136:1-6. PMID: 31265946.
      View in: PubMed
    5. Lewis T, Truog W, Norberg M, Ballard PL, Torgerson D. Correction: Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia. Pediatr Res. 2019 Apr; 85(5):731. PMID: 30733615.
      View in: PubMed
    6. Cuna A, Lewis T, Dai H, Nyp M, Truog WE. Timing of postnatal corticosteroid treatment for bronchopulmonary dysplasia and its effect on outcomes. Pediatr Pulmonol. 2019 02; 54(2):165-170. PMID: 30537393.
      View in: PubMed
    7. Lewis T, Truog W, Norberg M, Ballard PL, Torgerson D. Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia. Pediatr Res. 2019 04; 85(5):625-633. PMID: 30467342.
      View in: PubMed
    8. Phelps DL, Watterberg KL, Nolen TL, Cole CA, Cotten CM, Oh W, Poindexter BB, Zaterka-Baxter KM, Das A, Lacy CB, Scorsone AM, Walsh MC, Bell EF, Kennedy KA, Schibler K, Sokol GM, Laughon MM, Lakshminrusimha S, Truog WE, Garg M, Carlo WA, Laptook AR, Van Meurs KP, Carlton DP, Graf A, DeMauro SB, Brion LP, Shankaran S, Orge FH, Olson RJ, Mintz-Hittner H, Yang MB, Haider KM, Wallace DK, Chung M, Hug D, Tsui I, Cogen MS, Donahue JP, Gaynon M, Hutchinson AK, Bremer DL, Quinn G, He YG, Lucas WR, Winter TW, Kicklighter SD, Kumar K, Chess PR, Colaizy TT, Hibbs AM, Ambalavanan N, Harmon HM, McGowan EC, Higgins RD. Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial. JAMA. 2018 10 23; 320(16):1649-1658. PMID: 30357297.
      View in: PubMed
    9. Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 12; 203:218-224.e3. PMID: 30172426.
      View in: PubMed
    10. Kilbride H, Escobar H, Holmes A, Teson K, Truog W. Childhood Pulmonary Function, Exercise Capacity, and Exhaled Nitric Oxide Levels: Outcomes following Neonatal Treatment with Inhaled Nitric Oxide to Prevent Bronchopulmonary Dysplasia. Am J Perinatol. 2019 03; 36(4):360-365. PMID: 30121944.
      View in: PubMed
    11. Ballard PL, Keller RL, Truog WE, Chapin C, Horneman H, Segal MR, Ballard RA. Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment. Pediatr Res. 2019 02; 85(3):305-311. PMID: 30140069.
      View in: PubMed
    12. Akangire G, Manimtim W, Nyp MF, Noel-MacDonnell J, Kays AN, Truog WE, Taylor JB. Clinical Outcomes among Diagnostic Subgroups of Infants with Severe Bronchopulmonary Dysplasia through 2 Years of Age. Am J Perinatol. 2018 12; 35(14):1376-1387. PMID: 29852508.
      View in: PubMed
    13. Nyp MF, Taylor JB, Petralia A, Oschman A, Norberg M, Weatherly RA, Truog W, Manimtim W. Acute Post-Tracheostomy Clinical Decompensations in Infants-Are There Predictive Markers? Am J Perinatol. 2018 10; 35(12):1206-1212. PMID: 29702711.
      View in: PubMed
    14. Cuna A, Liu C, Govindarajan S, Queen M, Dai H, Truog WE. Usefulness of an Online Risk Estimator for Bronchopulmonary Dysplasia in Predicting Corticosteroid Treatment in Infants Born Preterm. J Pediatr. 2018 06; 197:23-28.e2. PMID: 29551313.
      View in: PubMed
    15. Srivastava T, Jafri S, Truog WE, Sebestyen VanSickle J, Manimtim WM, Alon US. Successful Reversal of Furosemide-Induced Secondary Hyperparathyroidism With Cinacalcet. Pediatrics. 2017 Dec; 140(6). PMID: 29192005.
      View in: PubMed
    16. Rosterman JL, Pallotto EK, Truog WE, Escobar H, Meinert KA, Holmes A, Dai H, Manimtim WM. The impact of neurally adjusted ventilatory assist mode on respiratory severity score and energy expenditure in infants: a randomized crossover trial. J Perinatol. 2018 01; 38(1):59-63. PMID: 29072677.
      View in: PubMed
    17. Laptook AR, Shankaran S, Tyson JE, Munoz B, Bell EF, Goldberg RN, Parikh NA, Ambalavanan N, Pedroza C, Pappas A, Das A, Chaudhary AS, Ehrenkranz RA, Hensman AM, Van Meurs KP, Chalak LF, Khan AM, Hamrick SEG, Sokol GM, Walsh MC, Poindexter BB, Faix RG, Watterberg KL, Frantz ID, Guillet R, Devaskar U, Truog WE, Chock VY, Wyckoff MH, McGowan EC, Carlton DP, Harmon HM, Brumbaugh JE, Cotten CM, Sánchez PJ, Hibbs AM, Higgins RD. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA. 2017 10 24; 318(16):1550-1560. PMID: 29067428.
      View in: PubMed
    18. Cuna A, Lewis T, Oschman A, Dai HY, Brophy K, Norberg M, Nyp M, Truog W. Outcomes of Infants Who Failed to Extubate despite Systemic Corticosteroids. Am J Perinatol. 2017 12; 34(14):1458-1463. PMID: 28704843.
      View in: PubMed
    19. Walsh MC, Bell EF, Kandefer S, Saha S, Carlo WA, D'angio CT, Laptook AR, Sanchez PJ, Stoll BJ, Shankaran S, Van Meurs KP, Cook N, Higgins RD, Das A, Newman NS, Schibler K, Schmidt B, Cotten CM, Poindexter BB, Watterberg KL, Truog WE. Neonatal outcomes of moderately preterm infants compared to extremely preterm infants. Pediatr Res. 2017 Aug; 82(2):297-304. PMID: 28419085.
      View in: PubMed
    20. Murthy VR, Escobar H, Norberg M, Lachica CI, Gratny LL, Sherman AK, Truog WE, Manimtim WM. A Novel Method of Measuring Fractional Exhaled Nitric Oxide in Tracheostomized Ventilator-Dependent Children. Respir Care. 2017 May; 62(5):595-601. PMID: 28246306.
      View in: PubMed
    21. Keller RL, Eichenwald EC, Hibbs AM, Rogers EE, Wai KC, Black DM, Ballard PL, Asselin JM, Truog WE, Merrill JD, Mammel MC, Steinhorn RH, Ryan RM, Durand DJ, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, Helderman J, Porta NF, Wadhawan R, Palermo L, Ballard RA. The Randomized, Controlled Trial of Late Surfactant: Effects on Respiratory Outcomes at 1-Year Corrected Age. J Pediatr. 2017 04; 183:19-25.e2. PMID: 28100402.
      View in: PubMed
    22. Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 02; 181:12-28.e1. PMID: 27908648.
      View in: PubMed
    23. Kirpalani H, Truog WE, D'Angio CT, Cotten M. Recent controversies on comparative effectiveness research investigations: Challenges, opportunities, and pitfalls. Semin Perinatol. 2016 10; 40(6):341-347. PMID: 27423511.
      View in: PubMed
    24. Archer SW, Carlo WA, Truog WE, Stevenson DK, Van Meurs KP, Sánchez PJ, Das A, Devaskar U, Nelin LD, Petrie Huitema CM, Crawford MM, Higgins RD. Improving publication rates in a collaborative clinical trials research network. Semin Perinatol. 2016 10; 40(6):410-417. PMID: 27423510.
      View in: PubMed
    25. Wai KC, Kohn MA, Ballard RA, Truog WE, Black DM, Asselin JM, Ballard PL, Rogers EE, Keller RL. Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns. J Pediatr. 2016 Oct; 177:97-102.e2. PMID: 27470692.
      View in: PubMed
    26. Truog WE, Higgins RD. Introduction. Semin Perinatol. 2016 10; 40(6):335-336. PMID: 27344191.
      View in: PubMed
    27. Das A, Tyson J, Pedroza C, Schmidt B, Gantz M, Wallace D, Truog WE, Higgins RD. Methodological issues in the design and analyses of neonatal research studies: Experience of the NICHD Neonatal Research Network. Semin Perinatol. 2016 10; 40(6):374-384. PMID: 27344192.
      View in: PubMed
    28. Ballard RA, Keller RL, Black DM, Ballard PL, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn RH, Rogers EE, Ryan RM, Durand DJ, Asselin JM, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, O'Shea TM, Porta NF, Wadhawan R, Palermo L. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr. 2016 Jan; 168:23-9.e4. PMID: 26500107.
      View in: PubMed
    29. Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, Laptook AR, Sánchez PJ, Van Meurs KP, Wyckoff M, Das A, Hale EC, Ball MB, Newman NS, Schibler K, Poindexter BB, Kennedy KA, Cotten CM, Watterberg KL, D'Angio CT, DeMauro SB, Truog WE, Devaskar U, Higgins RD. Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA. 2015 Sep 08; 314(10):1039-51. PMID: 26348753.
      View in: PubMed
    30. Taylor JB, Go MA, Nyp MF, Legino J, Norberg M, Dai H, Truog WE. Rehospitalization in Infants Born?
      View in: PubMed
    31. Truog WE. Bronchopulmonary dysplasia: another step along the path. J Pediatr. 2015 Mar; 166(3):521-2. PMID: 25556019.
      View in: PubMed
    32. Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Grisby C, Huitema CM, Garg M, Ehrenkranz RA, Shepherd EG, Chalak LF, Hamrick SE, Khan AM, Reynolds AM, Laughon MM, Truog WE, Dysart KC, Carlo WA, Walsh MC, Watterberg KL, Higgins RD. Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. JAMA. 2014 Dec 24-31; 312(24):2629-39. PMID: 25536254.
      View in: PubMed
    33. Laptook AR, Kilbride H, Shepherd E, McDonald SA, Shankaran S, Truog W, Das A, Higgins RD. Temperature control during therapeutic hypothermia for newborn encephalopathy using different Blanketrol devices. Ther Hypothermia Temp Manag. 2014 Dec; 4(4):193-200. PMID: 25285767.
      View in: PubMed
    34. Ballard PL, Keller RL, Black DM, Durand DJ, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn R, Ryan RM, Courtney SE, Horneman H, Ballard RA. Inhaled nitric oxide increases urinary nitric oxide metabolites and cyclic guanosine monophosphate in premature infants: relationship to pulmonary outcome. Am J Perinatol. 2015 Feb; 32(3):225-32. PMID: 24968129.
      View in: PubMed
    35. Truog WE, Nelin LD, Das A, Kendrick DE, Bell EF, Carlo WA, Higgins RD, Laptook AR, Sanchez PJ, Shankaran S, Stoll BJ, Van Meurs KP, Walsh MC. Inhaled nitric oxide usage in preterm infants in the NICHD Neonatal Research Network: inter-site variation and propensity evaluation. J Perinatol. 2014 Nov; 34(11):842-6. PMID: 24901452.
      View in: PubMed
    36. Nyp MF, Taylor JB, Norberg M, Truog WE. Impaired growth at birth and bronchopulmonary dysplasia classification: beyond small for gestational age. Am J Perinatol. 2015 Jan; 32(1):75-82. PMID: 24839148.
      View in: PubMed
    37. DeMauro SB, D'Agostino JA, Bann C, Bernbaum J, Gerdes M, Bell EF, Carlo WA, D'Angio CT, Das A, Higgins R, Hintz SR, Laptook AR, Natarajan G, Nelin L, Poindexter BB, Sanchez PJ, Shankaran S, Stoll BJ, Truog W, Van Meurs KP, Vohr B, Walsh MC, Kirpalani H. Developmental outcomes of very preterm infants with tracheostomies. J Pediatr. 2014 Jun; 164(6):1303-10.e2. PMID: 24472229.
      View in: PubMed
    38. Taylor JB, Nyp MF, Norberg M, Dai H, Escobar H, Ellerbeck E, Truog WE. Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia. J Perinatol. 2014 Mar; 34(3):223-8. PMID: 24335997.
      View in: PubMed
    39. Truog WE, Nyp MF, Taylor J, Gratny LL, Escobar H, Manimtim WM, Lachica CI, Khmour A, Oluola OO, Oshodi AA, Norberg M, Dai H, Pallotto EK. Infants born at <29 weeks: pulmonary outcomes from a hybrid perinatal system. J Perinatol. 2014 Jan; 34(1):59-63. PMID: 24135708.
      View in: PubMed
    40. Keller RL, Merrill JD, Black DM, Steinhorn RH, Eichenwald EC, Durand DJ, Ryan RM, Truog WE, Courtney SE, Ballard PL, Ballard RA. Late administration of surfactant replacement therapy increases surfactant protein-B content: a randomized pilot study. Pediatr Res. 2012 Dec; 72(6):613-9. PMID: 23037875.
      View in: PubMed
    41. Nyp M, Sandritter T, Poppinga N, Simon C, Truog WE. Sildenafil citrate, bronchopulmonary dysplasia and disordered pulmonary gas exchange: any benefits? J Perinatol. 2012 Jan; 32(1):64-9. PMID: 21941230.
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    42. Petrikin JE, Gaedigk R, Leeder JS, Truog WE. Selective Toll--like receptor expression in human fetal lung. Pediatr Res. 2010 Oct; 68(4):335-8. PMID: 20581745.
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    43. Golombek SG, Truog WE, Ballard RA, Ballard PL. Re: 'The use of iNO in the newborn period: results from the European iNO registry'. Acta Paediatr. 2010 Sep; 99(9):1283. PMID: 20456263.
      View in: PubMed
    44. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ, Truog WE, Ballard PL, Zadell A, Wadlinger SR, Coburn CE, Ballard RA. Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxide. J Pediatr. 2010 Apr; 156(4):556-61.e1. PMID: 20138299.
      View in: PubMed
    45. Hibbs AM, Black D, Palermo L, Cnaan A, Luan X, Truog WE, Walsh MC, Ballard RA. Accounting for multiple births in neonatal and perinatal trials: systematic review and case study. J Pediatr. 2010 Feb; 156(2):202-8. PMID: 19969305.
      View in: PubMed
    46. Zupancic JA, Hibbs AM, Palermo L, Truog WE, Cnaan A, Black DM, Ballard PL, Wadlinger SR, Ballard RA. Economic evaluation of inhaled nitric oxide in preterm infants undergoing mechanical ventilation. Pediatrics. 2009 Nov; 124(5):1325-32. PMID: 19841125.
      View in: PubMed
    47. Xu D, Perez RE, Rezaiekhaligh MH, Bourdi M, Truog WE. Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L44-51. PMID: 19411306.
      View in: PubMed
    48. Shao L, Perez RE, Gerthoffer WT, Truog WE, Xu D. Heat shock protein 27 protects lung epithelial cells from hyperoxia-induced apoptotic cell death. Pediatr Res. 2009 Mar; 65(3):328-33. PMID: 19047919.
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    49. Truog WE. 21st-century use for surfactant? Pediatrics. 2009 Jan; 123(1):173-4. PMID: 19117879.
      View in: PubMed
    50. Truog WE, Xu D, Ekekezie II, Mabry S, Rezaiekhaligh M, Svojanovsky S, Soares MJ. Chronic hypoxia and rat lung development: analysis by morphometry and directed microarray. Pediatr Res. 2008 Jul; 64(1):56-62. PMID: 18344904.
      View in: PubMed
    51. Hibbs AM, Walsh MC, Martin RJ, Truog WE, Lorch SA, Alessandrini E, Cnaan A, Palermo L, Wadlinger SR, Coburn CE, Ballard PL, Ballard RA. One-year respiratory outcomes of preterm infants enrolled in the Nitric Oxide (to prevent) Chronic Lung Disease trial. J Pediatr. 2008 Oct; 153(4):525-9. PMID: 18534620.
      View in: PubMed
    52. Truog WE, Martin RJ, Ballard RA, Black D, Cnaan A. Inhaled nitric oxide for preterm infants. Pediatrics. 2008 Jun; 121(6):1287-8; author reply 1288-9. PMID: 18519502.
      View in: PubMed
    53. Ballard PL, Truog WE, Merrill JD, Gow A, Posencheg M, Golombek SG, Parton LA, Luan X, Cnaan A, Ballard RA. Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infants. Pediatrics. 2008 Mar; 121(3):555-61. PMID: 18310205.
      View in: PubMed
    54. Xu D, Perez RE, Ekekezie II, Navarro A, Truog WE. Epidermal growth factor-like domain 7 protects endothelial cells from hyperoxia-induced cell death. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L17-23. PMID: 17934064.
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    55. Ballard PL, Merrill JD, Truog WE, Godinez RI, Godinez MH, McDevitt TM, Ning Y, Golombek SG, Parton LA, Luan X, Cnaan A, Ballard RA. Surfactant function and composition in premature infants treated with inhaled nitric oxide. Pediatrics. 2007 Aug; 120(2):346-53. PMID: 17671061.
      View in: PubMed
    56. Truog WE. Inhaled nitric oxide for the prevention of bronchopulmonary dysplasia. Expert Opin Pharmacother. 2007 Jul; 8(10):1505-13. PMID: 17661732.
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    57. Truog WE, Kurth G, Haney B, Kilbride HW. Hypoxic respiratory failure: etiology and outcomes at one referral center 2000 through 2005. J Perinatol. 2007 Jun; 27(6):371-4. PMID: 17443197.
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    58. Truog WE, Ballard PL, Norberg M, Golombek S, Savani RC, Merrill JD, Parton LA, Cnaan A, Luan X, Ballard RA. Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxide. Pediatrics. 2007 Apr; 119(4):670-8. PMID: 17403837.
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    59. Sheffield M, Mabry S, Thibeault DW, Truog WE. Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity. Pediatrics. 2006 Sep; 118(3):1056-64. PMID: 16950998.
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    60. Ballard RA, Truog WE, Cnaan A, Martin RJ, Ballard PL, Merrill JD, Walsh MC, Durand DJ, Mayock DE, Eichenwald EC, Null DR, Hudak ML, Puri AR, Golombek SG, Courtney SE, Stewart DL, Welty SE, Phibbs RH, Hibbs AM, Luan X, Wadlinger SR, Asselin JM, Coburn CE. Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med. 2006 Jul 27; 355(4):343-53. PMID: 16870913.
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    61. Xu D, Guthrie JR, Mabry S, Sack TM, Truog WE. Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L966-75. PMID: 16782756.
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    62. Ehlert CA, Truog WE, Thibeault DW, Garg U, Norberg M, Rezaiekhaligh M, Mabry S, Ekekezie II. Hyperoxia and tidal volume: Independent and combined effects on neonatal pulmonary inflammation. Biol Neonate. 2006; 90(2):89-97. PMID: 16534192.
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    63. Zhang X, Reinsvold P, Thibeault DW, Ekekezie II, Rezaiekhaligh M, Mabry SM, Buch S, Truog WE. Responses of pulmonary platelet-derived growth factor peptides and receptors to hyperoxia and nitric oxide in piglet lungs. Pediatr Res. 2005 Apr; 57(4):523-9. PMID: 15718371.
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    64. Merrill JD, Ballard RA, Cnaan A, Hibbs AM, Godinez RI, Godinez MH, Truog WE, Ballard PL. Dysfunction of pulmonary surfactant in chronically ventilated premature infants. Pediatr Res. 2004 Dec; 56(6):918-26. PMID: 15496605.
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    65. Ekekezie II, Thibeault DW, Simon SD, Norberg M, Merrill JD, Ballard RA, Ballard PL, Truog WE. Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease. Pediatrics. 2004 Jun; 113(6):1709-14. PMID: 15173495.
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    66. Thibeault DW, Mabry SM, Norberg M, Truog WE, Ekekezie II. Lung microvascular adaptation in infants with chronic lung disease. Biol Neonate. 2004; 85(4):273-82. PMID: 14739556.
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    67. Thibeault DW, Truog WE, Ekekezie II. Acinar arterial changes with chronic lung disease of prematurity in the surfactant era. Pediatr Pulmonol. 2003 Dec; 36(6):482-9. PMID: 14618639.
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    68. Olsen SL, Clark PL, Thibeault DW, Norberg M, Truog WE. Exhaled nitric oxide and tracheal endothelin-1 in preterm infants with and without RDS. Pediatr Pulmonol. 2003 Nov; 36(5):421-6. PMID: 14520725.
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    69. Ballard PL, Merrill JD, Godinez RI, Godinez MH, Truog WE, Ballard RA. Surfactant protein profile of pulmonary surfactant in premature infants. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1123-8. PMID: 12904326.
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    70. Thibeault DW, Mabry SM, Ekekezie II, Zhang X, Truog WE. Collagen scaffolding during development and its deformation with chronic lung disease. Pediatrics. 2003 Apr; 111(4 Pt 1):766-76. PMID: 12671110.
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    71. Ekekezie II, Thibeault DW, Rezaiekhaligh MH, Norberg M, Mabry S, Zhang X, Truog WE. Endostatin and vascular endothelial cell growth factor (VEGF) in piglet lungs: effect of inhaled nitric oxide and hyperoxia. Pediatr Res. 2003 Mar; 53(3):440-6. PMID: 12595592.
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    72. Truog WE. Genomics and complex neonatal disorders: maybe we're getting somewhere. J Perinatol. 2003 Mar; 23(2):91-3. PMID: 12708431.
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    73. Truog WE, Castor CA, Sheffield MJ. Neonatal nitric oxide use: predictors of response and financial implications. J Perinatol. 2003 Mar; 23(2):128-32. PMID: 12673262.
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    74. Kaftan HA, Clark PL, Norberg M, Garg U, Thibeault DW, Truog WE. Endogenous production of nitric oxide in endotoxemic piglets. Biol Neonate. 2003; 83(1):42-8. PMID: 12566683.
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    75. Thibeault DW, Olsen SL, Truog WE, Hubbell MM. Pre-ECMO predictors of nonsurvival in congenital diaphragmatic hernia. J Perinatol. 2002 Dec; 22(8):682-3; author reply 684. PMID: 12478457.
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    76. Olsen SL, Thibeault DW, Truog WE. Crossover trial comparing pressure support with synchronized intermittent mandatory ventilation. J Perinatol. 2002 Sep; 22(6):461-6. PMID: 12168123.
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    77. Truog WE, Pallotto E, Clark P, Banks B, Kaftan HA, Ekekezie II, Norberg M, Ballard RA. Interaction of endogenous endothelin-1 and inhaled nitric oxide in term and preterm infants. Clin Sci (Lond). 2002 Aug; 103 Suppl 48:294S-297S. PMID: 12193107.
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    78. Olsen SL, Thibeault DW, Mabry SM, Norberg M, Truog WE. Platelet endothelial cell adhesion molecule-1 and capillary loading in premature infants with and without chronic lung disease. Pediatr Pulmonol. 2002 Apr; 33(4):255-62. PMID: 11921454.
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    79. Clark PL, Ekekezie II, Kaftan HA, Castor CA, Truog WE. Safety and efficacy of nitric oxide in chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 2002 Jan; 86(1):F41-5. PMID: 11815547.
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    80. Ekekezie II, Thibeault DW, Garola RE, Truog WE. Monocyte chemoattractant protein-1 and its receptor CCR-2 in piglet lungs exposed to inhaled nitric oxide and hyperoxia. Pediatr Res. 2001 Nov; 50(5):633-40. PMID: 11641460.
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    81. Thibeault DW, Mabry SM, Ekekezie II, Truog WE. Lung elastic tissue maturation and perturbations during the evolution of chronic lung disease. Pediatrics. 2000 Dec; 106(6):1452-9. PMID: 11099603.
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    82. Ekekezie II, Thibeault DW, Rezaeikhaligh MH, Mabry SM, Norberg M, Reddy GK, Youssef J, Truog WE. High-dose inhaled nitric oxide and hyperoxia increases lung collagen accumulation in piglets. Biol Neonate. 2000 Oct; 78(3):198-206. PMID: 11044769.
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    83. Ekekezie II, Thibeault DW, Zwick DL, Rezaiekhaligh MH, Mabry SM, Morgan RE, Norberg M, Truog WE. Independent and combined effects of prolonged inhaled nitric oxide and oxygen on lung inflammation in newborn piglets. Biol Neonate. 2000; 77(1):37-44. PMID: 10658829.
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    84. Youssef JA, Thibeault DW, Rezaiekhaligh MH, Mabry SM, Norberg MI, Truog WE. Influence of inhaled nitric oxide and hyperoxia on Na,K-ATPase expression and lung edema in newborn piglets. Biol Neonate. 1999 Mar; 75(3):199-209. PMID: 9925907.
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    85. Thibeault DW, Rezaiekhaligh MH, Ekekezie I, Truog WE. Compressed air as a source of inhaled oxidants in intensive care units. Am J Perinatol. 1999; 16(9):497-501. PMID: 10774767.
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    86. Broughton AR, Thibeault DW, Mabry SM, Truog WE. Airway muscle in infants with congenital diaphragmatic hernia: response to treatment. J Pediatr Surg. 1998 Oct; 33(10):1471-5. PMID: 9802793.
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    87. Truog WE. Inhaled nitric oxide: a tenth anniversary observation. Pediatrics. 1998 Apr; 101(4 Pt 1):696-7. PMID: 9521957.
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    88. Goil S, Barnes C, Thibeault D, Truog WE. Simplified method for purification of colostrum to obtain secretory component of immunoglobulin A, using secretory component as a reference protein in tracheal aspirate fluid. J Chromatogr B Biomed Sci Appl. 1998 Feb 13; 705(2):203-11. PMID: 9521556.
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    89. Goil S, Truog WE, Barnes C, Norberg M, Rezaiekhaligh M, Thibeault D. Eight-epi-PGF2alpha: a possible marker of lipid peroxidation in term infants with severe pulmonary disease. J Pediatr. 1998 Feb; 132(2):349-51. PMID: 9506655.
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    90. Truog WE, Norberg M, Thibeault DW. Effect of inhaled nitric oxide in endothelin-1-induced pulmonary hypertension. Biol Neonate. 1998; 73(4):246-53. PMID: 9551191.
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    91. Sward-Comunelli SL, Mabry SM, Truog WE, Thibeault DW. Airway muscle in preterm infants: changes during development. J Pediatr. 1997 Apr; 130(4):570-6. PMID: 9108855.
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    92. Truog WE, Norberg M, Thibeault DW. Effects of 8-epi-prostaglandin F2 alpha and U46,619 on pulmonary hemodynamics in piglets. Biol Neonate. 1997; 71(5):306-16. PMID: 9167852.
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    93. Sumi SM, Truog WE, Kessler DM. Maternal corticosteroid therapy and the fetal brain in experimental hyaline membrane disease. Pediatr Res. 1984 May; 18(5):440-4. PMID: 6563518.
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