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Valentina Shakhnovich, MD

TitleGastroenterologist; Clinician-Scientist
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleResearch Assistant Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Wisconsin School of Medicine, Madison, WI MD2008
    University of Wisconsin School of Medicine, Madison, WI Residency2011Pediatrics
    Children's Mercy Kansas City, Kansas City, MOFellowship2014Pediatric Gastroenterology
    Children's Mercy Kansas City, Kansas City, MOFellowship2015Clinical Pharmacology
    Collapse credentials

    Collapse Overview 

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Schmidt K, Noel-MacDonnell J, Vyhlidal C, Heruth DP, Singh V, Ahmed AA, Hudson T, Williams V, Shakhnovich V. Characterization of the Mucosally-Adherent Duodenal Microbiome in Children with and without Crohn's Disease. Pharmaceuticals (Basel). 2022 Jul 11; 15(7). PMID: 35890149.
      View in: PubMed
    2. Hosey CM, Halpin K, Shakhnovich V, Bi C, Sweeney B, Yan Y, Leeder JS. Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models. Clin Transl Sci. 2022 04; 15(4):912-922. PMID: 35297172.
      View in: PubMed
    3. Feldman K, Kearns GL, Pearce RE, Abdel-Rahman SM, Steven Leeder J, Friesen A, Staggs VS, Gaedigk A, Weigel J, Shakhnovich V. Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children. Clin Transl Sci. 2022 05; 15(5):1155-1166. PMID: 35099109.
      View in: PubMed
    4. Chang HP, Shakhnovich V, Frymoyer A, Funk RS, Becker ML, Park KT, Shah DK. A population physiologically-based pharmacokinetic model to characterize antibody disposition in pediatrics and evaluation of the model using infliximab. Br J Clin Pharmacol. 2022 01; 88(1):290-302. PMID: 34189743.
      View in: PubMed
    5. Hosey-Cojocari C, Chan SS, Friesen CS, Robinson A, Williams V, Swanson E, O'Toole D, Radford J, Mardis N, Johnson TN, Leeder JS, Shakhnovich V. Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study. Clin Transl Sci. 2021 09; 14(5):2008-2016. PMID: 33982422.
      View in: PubMed
    6. Morrow R, Funk R, Becker M, Sherman A, Van Haandel L, Hudson T, Casini R, Shakhnovich V. Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2021 May 14; 14(5). PMID: 34069031.
      View in: PubMed
    7. Funk RS, Shakhnovich V, Cho YK, Polireddy K, Jausurawong T, Gress K, Becker ML. Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study. Pediatr Rheumatol Online J. 2021 May 01; 19(1):62. PMID: 33933127.
      View in: PubMed
    8. Friesen CS, Hosey-Cojocari C, Chan SS, Csanaky IL, Wagner JB, Sweeney BR, Friesen A, Fraser JD, Shakhnovich V. Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy. Front Endocrinol (Lausanne). 2021; 12:663351. PMID: 33927697.
      View in: PubMed
    9. Kyler KE, Bettenhausen JL, Hall M, Glynn EF, Hoffman MA, Shakhnovich V, Smolderen K, Davis AM. Obesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma. Hosp Pediatr. 2021 04; 11(4):380-388. PMID: 33664119.
      View in: PubMed
    10. Friesen CS, Chan SS, Wagner JB, Hosey-Cojocari C, Csanaky IL, Shakhnovich V. Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective. Clin Transl Sci. 2021 05; 14(3):781-783. PMID: 33476465.
      View in: PubMed
    11. Vyhlidal CA, Chapron BD, Ahmed A, Singh V, Casini R, Shakhnovich V. Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine. Clin Transl Sci. 2021 03; 14(2):729-736. PMID: 33278326.
      View in: PubMed
    12. Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. Clin Pharmacol Ther. 2021 06; 109(6):1417-1423. PMID: 32770672.
      View in: PubMed
    13. Gress K, Bass JA, Funk RS, Morrow RP, Hasenkamp R, Shakhnovich V. Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease. Front Immunol. 2020; 11:1148. PMID: 32582213.
      View in: PubMed
    14. Shakhnovich V, Kyler KE. Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity. Obesity (Silver Spring). 2020 06; 28(6):1003. PMID: 32441475.
      View in: PubMed
    15. Shakhnovich V, Meibohm B, Rosenberg A, Kierzek AM, Hasenkamp R, Funk RS, Thalhauser CJ, van der Graaf PH, Wang YC, Hamuro L. Immunogenicity in Clinical Practice and Drug Development: When is it Significant? Clin Transl Sci. 2020 03; 13(2):219-223. PMID: 31762152.
      View in: PubMed
    16. Kyler KE, Wagner J, Hosey-Cojocari C, Watt K, Shakhnovich V. Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children. Paediatr Drugs. 2019 Oct; 21(5):357-369. PMID: 31432433.
      View in: PubMed
    17. Gijsen V, Maddux M, Lavertu A, Gonzalez-Hernandez G, Ram N, Reeves B, Robinson T, Ziesenitz V, Shakhnovich V, Altman R. #Science: The Potential and the Challenges of Utilizing Social Media and Other Electronic Communication Platforms in Health Care. Clin Transl Sci. 2020 01; 13(1):26-30. PMID: 31392837.
      View in: PubMed
    18. White DA, Staggs VS, Williams V, Edwards TC, Shook R, Shakhnovich V. Handheld Indirect Calorimetry as a Clinical Tool for Measuring Resting Energy Expenditure in Children with and without Obesity. Child Obes. 2019 May/Jun; 15(4):280-287. PMID: 30888207.
      View in: PubMed
    19. Shakhnovich V, Hornik CP, Kearns GL, Weigel J, Abdel-Rahman SM. How to Conduct Clinical Trials in Children: A Tutorial. Clin Transl Sci. 2019 05; 12(3):218-230. PMID: 30657253.
      View in: PubMed
    20. McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 03; 12(2):140-150. PMID: 30516322.
      View in: PubMed
    21. Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. Paediatr Drugs. 2018 Oct; 20(5):483-495. PMID: 30097906.
      View in: PubMed
    22. Shakhnovich V, Smith PB, Wu H, Cohen-Wolkowiez M, Kearns GL. Reply. J Pediatr. 2018 07; 198:327-328. PMID: 29680472.
      View in: PubMed
    23. Shakhnovich V. It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm. Clin Transl Sci. 2018 03; 11(2):98-99. PMID: 29423973.
      View in: PubMed
    24. Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. J Pediatr. 2018 02; 193:102-108.e1. PMID: 29389444.
      View in: PubMed
    25. Andreoletti G, Shakhnovich V, Christenson K, Coelho T, Haggarty R, Afzal NA, Batra A, Petersen BS, Mort M, Beattie RM, Ennis S. Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway. Sci Rep. 2017 04 19; 7:46454. PMID: 28422189.
      View in: PubMed
    26. Shakhnovich V, Dinwiddie D, Hildreth A, Attard T, Kingsmore S. A Novel Compound-Heterozygous Epithelial Cell Adhesion Molecule Mutation in Tufting Enteropathy. J Pediatr Gastroenterol Nutr. 2017 01; 64(1):e14-e16. PMID: 25383784.
      View in: PubMed
    27. Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS. Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease. Drug Metab Dispos. 2016 07; 44(7):1066-9. PMID: 27013401.
      View in: PubMed
    28. Bass JA, Friesen CA, Deacy AD, Neilan NA, Bracken JM, Shakhnovich V, Singh V. Investigation of potential early Histologic markers of pediatric inflammatory bowel disease. BMC Gastroenterol. 2015 Oct 13; 15:129. PMID: 26463759.
      View in: PubMed
    29. Turner D, Wolters VM, Russell RK, Shakhnovich V, Muise AM, Ledder O, Ngan B, Friesen C. Anti-TNF, infliximab, and adalimumab can be effective in eosinophilic bowel disease. J Pediatr Gastroenterol Nutr. 2013 May; 56(5):492-7. PMID: 23221994.
      View in: PubMed
    30. Shakhnovich V, Daniel J, Wicklund B, Kearns G, Neville K. Use of pharmacokinetic modelling to individualize FFP dosing in factor V deficiency. Haemophilia. 2013 Mar; 19(2):251-5. PMID: 23173558.
      View in: PubMed
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