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Valentina Shakhnovich, MD

TitleGastroenterologist; Clinician-Scientist
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitleAssistant Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleResearch Assistant Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Wisconsin School of Medicine, Madison, WI MD2008
    University of Wisconsin School of Medicine, Madison, WI Residency2011Pediatrics
    Children's Mercy Kansas City, Kansas City, MOFellowship2015Clinical Pharmacology
    Children's Mercy Kansas City, Kansas City, MOFellowship2015Pediatric Gastroenterology
    Collapse credentials

    Collapse Overview 

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kyler KE, Bettenhausen JL, Hall M, Glynn EF, Hoffman MA, Shakhnovich V, Smolderen K, Davis AM. Obesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma. Hosp Pediatr. 2021 Apr; 11(4):380-388. PMID: 33664119.
      View in: PubMed
    2. Friesen CS, Chan SS, Wagner JB, Hosey-Cojocari C, Csanaky IL, Shakhnovich V. Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective. Clin Transl Sci. 2021 Jan 21. PMID: 33476465.
      View in: PubMed
    3. Vyhlidal CA, Chapron BD, Ahmed A, Singh V, Casini R, Shakhnovich V. Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine. Clin Transl Sci. 2021 Mar; 14(2):729-736. PMID: 33278326.
      View in: PubMed
    4. Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. Clin Pharmacol Ther. 2020 Aug 08. PMID: 32770672.
      View in: PubMed
    5. Gress K, Bass JA, Funk RS, Morrow RP, Hasenkamp R, Shakhnovich V. Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease. Front Immunol. 2020; 11:1148. PMID: 32582213.
      View in: PubMed
    6. Shakhnovich V, Kyler KE. Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity. Obesity (Silver Spring). 2020 06; 28(6):1003. PMID: 32441475.
      View in: PubMed
    7. Shakhnovich V, Meibohm B, Rosenberg A, Kierzek AM, Hasenkamp R, Funk RS, Thalhauser CJ, van der Graaf PH, Wang YC, Hamuro L. Immunogenicity in Clinical Practice and Drug Development: When is it Significant? Clin Transl Sci. 2020 03; 13(2):219-223. PMID: 31762152.
      View in: PubMed
    8. Kyler KE, Wagner J, Hosey-Cojocari C, Watt K, Shakhnovich V. Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children. Paediatr Drugs. 2019 Oct; 21(5):357-369. PMID: 31432433.
      View in: PubMed
    9. Gijsen V, Maddux M, Lavertu A, Gonzalez-Hernandez G, Ram N, Reeves B, Robinson T, Ziesenitz V, Shakhnovich V, Altman R. #Science: The Potential and the Challenges of Utilizing Social Media and Other Electronic Communication Platforms in Health Care. Clin Transl Sci. 2020 01; 13(1):26-30. PMID: 31392837.
      View in: PubMed
    10. White DA, Staggs VS, Williams V, Edwards TC, Shook R, Shakhnovich V. Handheld Indirect Calorimetry as a Clinical Tool for Measuring Resting Energy Expenditure in Children with and without Obesity. Child Obes. 2019 May/Jun; 15(4):280-287. PMID: 30888207.
      View in: PubMed
    11. Shakhnovich V, Hornik CP, Kearns GL, Weigel J, Abdel-Rahman SM. How to Conduct Clinical Trials in Children: A Tutorial. Clin Transl Sci. 2019 05; 12(3):218-230. PMID: 30657253.
      View in: PubMed
    12. McLaughlin MJ, Wagner J, Shakhnovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 03; 12(2):140-150. PMID: 30516322.
      View in: PubMed
    13. Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. Paediatr Drugs. 2018 Oct; 20(5):483-495. PMID: 30097906.
      View in: PubMed
    14. Shakhnovich V, Smith PB, Wu H, Cohen-Wolkowiez M, Kearns GL. Reply. J Pediatr. 2018 07; 198:327-328. PMID: 29680472.
      View in: PubMed
    15. Shakhnovich V. It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm. Clin Transl Sci. 2018 03; 11(2):98-99. PMID: 29423973.
      View in: PubMed
    16. Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. J Pediatr. 2018 02; 193:102-108.e1. PMID: 29389444.
      View in: PubMed
    17. Andreoletti G, Shakhnovich V, Christenson K, Coelho T, Haggarty R, Afzal NA, Batra A, Petersen BS, Mort M, Beattie RM, Ennis S. Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway. Sci Rep. 2017 04 19; 7:46454. PMID: 28422189.
      View in: PubMed
    18. Shakhnovich V, Dinwiddie D, Hildreth A, Attard T, Kingsmore S. A Novel Compound-Heterozygous Epithelial Cell Adhesion Molecule Mutation in Tufting Enteropathy. J Pediatr Gastroenterol Nutr. 2017 01; 64(1):e14-e16. PMID: 25383784.
      View in: PubMed
    19. Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS. Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease. Drug Metab Dispos. 2016 07; 44(7):1066-9. PMID: 27013401.
      View in: PubMed
    20. Bass JA, Friesen CA, Deacy AD, Neilan NA, Bracken JM, Shakhnovich V, Singh V. Investigation of potential early Histologic markers of pediatric inflammatory bowel disease. BMC Gastroenterol. 2015 Oct 13; 15:129. PMID: 26463759.
      View in: PubMed
    21. Turner D, Wolters VM, Russell RK, Shakhnovich V, Muise AM, Ledder O, Ngan B, Friesen C. Anti-TNF, infliximab, and adalimumab can be effective in eosinophilic bowel disease. J Pediatr Gastroenterol Nutr. 2013 May; 56(5):492-7. PMID: 23221994.
      View in: PubMed
    22. Shakhnovich V, Daniel J, Wicklund B, Kearns G, Neville K. Use of pharmacokinetic modelling to individualize FFP dosing in factor V deficiency. Haemophilia. 2013 Mar; 19(2):251-5. PMID: 23173558.
      View in: PubMed
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