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Ryan T. Fischer, MD

TitleChief, Section of Hepatology and Transport Medicine
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitlePediatric Transplant Hepatologist
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Nebraska, Omaha, NEMD2002
    Children's Hospital of Pittsburgh, Pittsburgh, PAFellowship2008Pediatric Gastroenterology
    Children's Hospital of Pittsburgh, Pittsburgh, PAFellowship2009Pediatric Transplant Hepatology

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Fischer is a board-certified Pediatric Gastroenterologist and Transplant Hepatologist at Children's Mercy Hospital in Kansas City. He has a strong interest in translational research related to liver disease and transplantation, and novel therapeutics to treat disordered inflammation in the liver. Dr. Fischer’s background in the lab includes basic research in dendritic cell biology, antigen presentation and cell-based immunotherapy. In collaboration with the University of Kansas’s Department of Microbiology, Immunology and Genetics, he is working to harness the potential of regulatory T cells for the modulation of liver allograft rejection. Clinically, his focus is on the diagnosis and treatment of liver disease in children, with a great deal of time devoted to children that need or have undergone liver transplantation. The hepatology team specializes in fatty liver disease, drug-induced liver injury, progressive liver fibrosis, and liver disease related to congenital heart disease.

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Fischer RT, Day JC, Wasserkrug H, Faseler M, Kats A, Daniel JF, Slowik V, Andrews W, Hendrickson RJ. Complications of Cryptosporidium infection after pediatric liver transplantation: Diarrhea, rejection, and biliary disease. Pediatr Transplant. 2020 Aug 10; e13807. PMID: 32777150.
      View in: PubMed
    2. Emamaullee J, Zaidi AN, Schiano T, Kahn J, Valentino PL, Hofer RE, Taner T, Wald JW, Olthoff KM, Bucuvalas J, Fischer R. Fontan-Associated Liver Disease: Screening, Management, and Transplant Considerations. Circulation. 2020 Aug 11; 142(6):591-604. PMID: 32776846.
      View in: PubMed
    3. Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J. Big Data in Transplantation Practice - the Devil Is in the Detail - Fontan-associated Liver Disease. Transplantation. 2020 Jul 02. PMID: 32639398.
      View in: PubMed
    4. Simon DA, Fleishman NR, Choi P, Fraser JD, Fischer RT. Torsion of an Accessory Spleen in a Child With Biliary Atresia Splenic Malformation Syndrome. Front Pediatr. 2020; 8:220. PMID: 32432066.
      View in: PubMed
    5. Seng A, Krausz KL, Pei D, Koestler DC, Fischer RT, Yankee TM, Markiewicz MA. Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells. Blood Adv. 2020 Apr 14; 4(7):1325-1339. PMID: 32259202.
      View in: PubMed
    6. Tarantino IS, Tennill T, Fraga G, Fischer R. Cutaneous metastases from esophageal adenocarcinoma on the scalp. Cutis. 2020 Mar; 105(3):E3-E4. PMID: 32352439.
      View in: PubMed
    7. Ryan JL, Dandridge LM, Andrews WS, Daniel JF, Fischer RT, Rivard DC, Wieser AB, Kane BJ, Hendrickson RJ. Conservative Management of Pneumatosis Intestinalis and Portal Venous Gas After Pediatric Liver Transplantation. Transplant Proc. 2020 Apr; 52(3):938-942. PMID: 32122661.
      View in: PubMed
    8. Sandritter TL, Goldman JL, Habiger CJ, Daniel JF, Lowry J, Fischer RT. An electronic medical records-based approach to identify idiosyncratic drug-induced liver injury in children. Sci Rep. 2019 12 02; 9(1):18090. PMID: 31792283.
      View in: PubMed
    9. Ng VL, Mazariegos GV, Kelly B, Horslen S, McDiarmid SV, Magee JC, Loomes KM, Fischer RT, Sundaram SS, Lai JC, Te HS, Bucuvalas JC. Barriers to ideal outcomes after pediatric liver transplantation. Pediatr Transplant. 2019 09; 23(6):e13537. PMID: 31343109.
      View in: PubMed
    10. Halma J, Petrikin J, Daniel JF, Fischer RT. Dehydrated Hereditary Stomatocytosis Presenting as Severe Perinatal Ascites and Cholestasis. J Pediatr Gastroenterol Nutr. 2019 Mar; 68(3):e52-e53. PMID: 29952828.
      View in: PubMed
    11. Hendrickson RJ, Sujka J, Fischer R, Manalang M, Daniel J, Andrews WS. Indications and efficacy of conversion from tacrolimus- to sirolimus-based immunosuppression in pediatric patients who underwent liver transplantation for unresectable hepatoblastoma. Pediatr Transplant. 2019 05; 23(3):e13369. PMID: 30719825.
      View in: PubMed
    12. Sujka J, Gonzalez KW, Curiel KL, Daniel J, Fischer RT, Andrews WS, Wicklund BM, Hendrickson RJ. The impact of thromboelastography on resuscitation in pediatric liver transplantation. Pediatr Transplant. 2018 06; 22(4):e13176. PMID: 29577520.
      View in: PubMed
    13. Akangire G, Cuna A, Lachica C, Fischer R, Raman S, Sampath V. Neonatal Graves' Disease with Maternal Hypothyroidism. AJP Rep. 2017 Jul; 7(3):e181-e184. PMID: 28948062.
      View in: PubMed
    14. Pant C, Sferra TJ, Fischer RT, Olyaee M, Gilroy R. Epidemiology and Healthcare Resource Utilization Associated With Children With Short Bowel Syndrome in the United States. JPEN J Parenter Enteral Nutr. 2017 07; 41(5):878-883. PMID: 26518221.
      View in: PubMed
    15. Willig LK, Petrikin JE, Smith LD, Saunders CJ, Thiffault I, Miller NA, Soden SE, Cakici JA, Herd SM, Twist G, Noll A, Creed M, Alba PM, Carpenter SL, Clements MA, Fischer RT, Hays JA, Kilbride H, McDonough RJ, Rosterman JL, Tsai SL, Zellmer L, Farrow EG, Kingsmore SF. Whole-genome sequencing for identification of Mendelian disorders in critically ill infants: a retrospective analysis of diagnostic and clinical findings. Lancet Respir Med. 2015 May; 3(5):377-87. PMID: 25937001.
      View in: PubMed
    16. Fischer RT, Friend B, Talmon GA, Grant WJ, Quiros-Tejeira RE, Langnas AN, Coccia PF. Intestinal transplantation in children with multiple intestinal atresias and immunodeficiency. Pediatr Transplant. 2014 Mar; 18(2):190-6. PMID: 24373162.
      View in: PubMed
    17. Infantino BJ, Mercer DF, Hobson BD, Fischer RT, Gerhardt BK, Grant WJ, Langnas AN, Quiros-Tejeira RE. Successful rehabilitation in pediatric ultrashort small bowel syndrome. J Pediatr. 2013 Nov; 163(5):1361-6. PMID: 23866718.
      View in: PubMed
    18. Acquazzino MA, Fischer RT, Langnas A, Coulter DW. Refractory autoimmune hemolytic anemia after intestinal transplant responding to conversion from a calcineurin to mTOR inhibitor. Pediatr Transplant. 2013 Aug; 17(5):466-71. PMID: 23730873.
      View in: PubMed
    19. Mercer DF, Hobson BD, Fischer RT, Talmon GA, Perry DA, Gerhardt BK, Grant WJ, Botha JF, Langnas AN, Quiros-Tejeira RE. Hepatic fibrosis persists and progresses despite biochemical improvement in children treated with intravenous fish oil emulsion. J Pediatr Gastroenterol Nutr. 2013 Apr; 56(4):364-9. PMID: 23201707.
      View in: PubMed
    20. Talmon G, El Behery R, Radio S, Fischer R, Shostrom V, Wisecarver J. Crypt apoptotic count reproducibility in small bowel allograft biopsies. Int J Surg Pathol. 2013 Jun; 21(3):257-60. PMID: 22832111.
      View in: PubMed
    21. Fischer RT, Turnquist HR, Wang Z, Beer-Stolz D, Thomson AW. Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen-specific CD8(+) T cells in vitro and in vivo. Transpl Immunol. 2011 Jul; 25(1):20-6. PMID: 21596137.
      View in: PubMed
    22. Fischer RT, Soltys KA, Squires RH, Jaffe R, Mazariegos GV, Shneider BL. Prognostic scoring indices in Wilson disease: a case series and cautionary tale. J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):466-9. PMID: 21415672.
      View in: PubMed
    23. Turnquist HR, Fischer RT, Thomson AW. Pharmacological modification of dendritic cells to promote their tolerogenicity in transplantation. Methods Mol Biol. 2010; 595:135-48. PMID: 19941109.
      View in: PubMed
    24. Fischer R, Shneider B. Treatment of non-alcoholic fatty liver disease in children: swim at your own risk. Pediatr Diabetes. 2009 Feb; 10(1):1-4. PMID: 19161394.
      View in: PubMed
    25. Fischer R, Turnquist HR, Taner T, Thomson AW. Use of rapamycin in the induction of tolerogenic dendritic cells. Handb Exp Pharmacol. 2009; (188):215-32. PMID: 19031028.
      View in: PubMed
    26. Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol. 2007 Jun 01; 178(11):7018-31. PMID: 17513751.
      View in: PubMed
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