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Ryan T. Fischer, MD

TitleChief, Section of Hepatology and Transport Medicine
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
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    Other Positions
    TitlePediatric Transplant Hepatologist
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Nebraska, Omaha, NEMD2002
    Children's Hospital of Pittsburgh, Pittsburgh, PAFellowship2008Pediatric Gastroenterology
    Children's Hospital of Pittsburgh, Pittsburgh, PAFellowship2009Pediatric Transplant Hepatology

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Fischer is a board-certified Pediatric Gastroenterologist and Transplant Hepatologist at Children's Mercy Hospital in Kansas City. He has a strong interest in translational research related to liver disease and transplantation, and novel therapeutics to treat disordered inflammation in the liver. Dr. Fischer’s background in the lab includes basic research in dendritic cell biology, antigen presentation and cell-based immunotherapy. In collaboration with the University of Kansas’s Department of Microbiology, Immunology and Genetics, he is working to harness the potential of regulatory T cells for the modulation of liver allograft rejection. Clinically, his focus is on the diagnosis and treatment of liver disease in children, with a great deal of time devoted to children that need or have undergone liver transplantation. The hepatology team specializes in fatty liver disease, drug-induced liver injury, progressive liver fibrosis, and liver disease related to congenital heart disease.

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ovchinsky N, Aumar M, Baker A, Baumann U, Bufler P, Cananzi M, Czubkowski P, Durmaz ?, Fischer R, Indolfi G, Karnsakul WW, Lacaille F, Lee WS, Maggiore G, Rosenthal P, Ruiz M, Sokal E, Sturm E, van der Woerd W, Verkade HJ, Wehrman A, Clemson C, Yu Q, Ni Q, Ruvido J, Manganaro S, Mattsson JP. Efficacy and safety of odevixibat in patients with Alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2024 Jul; 9(7):632-645. PMID: 38670135.
      View in: PubMed
    2. Hansen BE, Vandriel SM, Vig P, Garner W, Mogul DB, Loomes KM, Piccoli DA, Rand EB, Jankowska I, Czubkowski P, Gliwicz-Miedzinska D, Gonzales EM, Jacquemin E, Bouligand J, D'Antiga L, Nicastro E, Arnell H, Fischler B, Sokal ?, Demaret T, Siew S, Stormon M, Karpen SJ, Romero R, Ebel NH, Feinstein JA, Roberts AJ, Evans HM, Sundaram SS, Chaidez A, Hardikar W, Shankar S, Fischer RT, Lacaille F, Debray D, Lin HC, Jensen MK, Jaramillo C, Karthikeyan P, Indolfi G, Verkade HJ, Larson-Nath C, Quiros-Tejeira RE, Valentino PL, Rogalidou M, Dezsofi A, Squires JE, Schwarz K, Calvo PL, Bernabeu JQ, Zizzo AN, Nebbia G, Bulut P, Santos-Silva E, Fawaz R, Nastasio S, Karnsakul W, Tamara ML, Busoms CM, Kelly DA, Sandahl TD, Jimenez-Rivera C, Banales JM, Mujawar Q, Li LT, She H, Wang JS, Kim KM, Oh SH, Sanchez MC, Cavalieri ML, Lee WS, Hajinicolaou C, Lertudomphonwanit C, Waisbourd-Zinman O, Arikan C, Alam S, Carvalho E, Melere M, Eshun J, ?nal Z, Desai DM, Wiecek S, Pinto RB, Wolters VM, Garcia J, Beretta M, Kerkar N, Brecelj J, Rock N, Lurz E, Blondet N, Shah U, Thompson RJ, Kamath BM. Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA. Hepatology. 2024 06 01; 79(6):1279-1292. PMID: 38146932.
      View in: PubMed
    3. Fischer RT. Looking for literal improvement in liver transplant outcomes. Liver Transpl. 2024 04 01; 30(4):343-344. PMID: 38100169.
      View in: PubMed
    4. Feldman K, Heble DE, Hendrickson RJ, Fischer RT. Hepatic artery thrombosis and use of anticoagulants and antiplatelet agents in pediatric liver transplantation. Pediatr Transplant. 2024 02; 28(1):e14516. PMID: 37550273.
      View in: PubMed
    5. Alfares BA, van der Doef HPJ, Wildhaber BE, Casswall T, Nowak G, Delle M, Aldrian D, Berchtold V, Vogel GF, Kalicinski P, Markiewicz-Kijewska M, Kolesnik A, Bernabeu JQ, Hally MM, Larrarte K M, Marra P, Bravi M, Pinelli D, Kasahara M, Sakamoto S, Uchida H, Mali V, Aw M, Franchi-Abella S, Gonzales E, Gu?rin F, Cervio G, Minetto J, Sierre S, de Santiba?es M, Ardiles V, Uno JW, Evans H, Duncan D, McCall J, Hartleif S, Sturm E, Patel J, Mtegha M, Prasad R, Ferreira CT, Nader LS, Farina M, Jaramillo C, Rodriguez-Davalos MI, Feola P, Shah AA, Wood PM, Acord MR, Fischer RT, Mullapudi B, Hendrickson RJ, Khanna R, Pamecha V, Mukund A, Sharif K, Gupte G, McGuirk S, Porta G, Spada M, Alterio T, Maggiore G, Hardikar W, Beretta M, Dierckx R, de Kleine RHJ, Bokkers RPH. Prevalence, management and efficacy of treatment in portal vein obstruction after paediatric liver transplantation: protocol of the retrospective international multicentre PORTAL registry. BMJ Open. 2023 07 27; 13(7):e066343. PMID: 37500271.
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    6. Santharam Y, Nitkin CR, Rajgarhia A, Oschman A, Lee B, Fischer R, Feldman K. Association between congenital heart disease and parenteral nutrition-associated liver disease in neonates: A retrospective cohort study. JPEN J Parenter Enteral Nutr. 2023 05; 47(4):501-510. PMID: 36772965.
      View in: PubMed
    7. Ali AH, Buness CW, Fischer R, Holtmann GJ, Shah A, Lewindon P, Shah S, Ragnekar AS, Taylor AE, Goel A, Cox KL, Alrabadi L, Wadsworth S, Kulkarni SS, Lindor KD. Letter to the Editor: Insurance should cover vancomycin for primary sclerosing cholangitis. Hepatology. 2023 06 01; 77(6):E174-E175. PMID: 36705026.
      View in: PubMed
    8. Felzen A, van Wessel DBE, Gonzales E, Thompson RJ, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipinski P, Czubkowski P, Rock N, Shagrani M, Broering D, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JBF, Serranti D, Arikan C, Polat E, Debray D, Lacaille F, Goncalves C, Hierro L, Mu?oz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsofi A, Calvo PL, Grabhorn E, Hartleif S, van der Woerd WJ, Kamath BM, Wang JS, Li L, Durmaz ?, Kerkar N, J?rgensen MH, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Ferreira CT, Guerrero FO, Wang H, Sency V, Kim KM, Chen HL, de Carvalho E, Fabre A, Bernabeu JQ, Zellos A, Alonso EM, Sokol RJ, Suchy FJ, Loomes KM, McKiernan PJ, Rosenthal P, Turmelle Y, Horslen S, Schwarz K, Bezerra JA, Wang K, Hansen BE, Verkade HJ. Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency. JHEP Rep. 2023 Feb; 5(2):100626. PMID: 36687469.
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    9. Morgans HA, Bradley T, Flebbe-Rehwaldt L, Selvarangan R, Bagherian A, Barnes AP, Bass J, Cooper AM, Fischer R, Kleiboeker S, Lee BR, LeMaster C, Markus K, Morrison S, Myers A, Myers D, Payne E, Schuster JE, Standley S, Wieser A, Warady B. Humoral and cellular response to the COVID-19 vaccine in immunocompromised children. Pediatr Res. 2023 07; 94(1):200-205. PMID: 36376507.
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    10. Vandriel SM, Li LT, She H, Wang JS, Gilbert MA, Jankowska I, Czubkowski P, Gliwicz-Miedzinska D, Gonzales EM, Jacquemin E, Bouligand J, Spinner NB, Loomes KM, Piccoli DA, D'Antiga L, Nicastro E, Sokal ?, Demaret T, Ebel NH, Feinstein JA, Fawaz R, Nastasio S, Lacaille F, Debray D, Arnell H, Fischler B, Siew S, Stormon M, Karpen SJ, Romero R, Kim KM, Baek WY, Hardikar W, Shankar S, Roberts AJ, Evans HM, Jensen MK, Kavan M, Sundaram SS, Chaidez A, Karthikeyan P, Sanchez MC, Cavalieri ML, Verkade HJ, Lee WS, Squires JE, Hajinicolaou C, Lertudomphonwanit C, Fischer RT, Larson-Nath C, Mozer-Glassberg Y, Arikan C, Lin HC, Bernabeu JQ, Alam S, Kelly DA, Carvalho E, Ferreira CT, Indolfi G, Quiros-Tejeira RE, Bulut P, Calvo PL, ?nal Z, Valentino PL, Desai DM, Eshun J, Rogalidou M, Dezsofi A, Wiecek S, Nebbia G, Pinto RB, Wolters VM, Tamara ML, Zizzo AN, Garcia J, Schwarz K, Beretta M, Sandahl TD, Jimenez-Rivera C, Kerkar N, Brecelj J, Mujawar Q, Rock N, Busoms CM, Karnsakul W, Lurz E, Santos-Silva E, Blondet N, Bujanda L, Shah U, Thompson RJ, Hansen BE, Kamath BM. Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Hepatology. 2023 02 01; 77(2):512-529. PMID: 36036223.
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    11. Vittorio J, Kosmach-Park B, King LY, Fischer R, Fredericks EM, Ng VL, Narang A, Rasmussen S, Bucuvalas J. Health Care Transition for Adolescents and Young Adults With Pediatric-Onset Liver Disease and Transplantation: A Position Paper by the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2023 01 01; 76(1):84-101. PMID: 35830731.
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    12. Ryan JL, Sherman AK, Heble DE, Friesen CA, Daniel JF, Fischer RT, Slowik V. The effect of neuropsychiatric medication on pediatric nonalcoholic fatty liver disease. Clin Transl Sci. 2022 09; 15(9):2241-2250. PMID: 35769031.
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    13. Slowik V, Bernardez A, Wasserkrug H, Fischer RT, Daniel JF, Grammatikopoulos T. Use and safety of prophylactic endoscopy from a single center serving urban and rural children with portal hypertension. Sci Rep. 2022 01 07; 12(1):25. PMID: 34996951.
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    14. Halma J, Pierce S, McLennan R, Bradley T, Fischer R. Natural killer cells in liver transplantation: Can we harness the power of the immune checkpoint to promote tolerance? Clin Transl Sci. 2022 05; 15(5):1091-1103. PMID: 34866338.
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    15. van Wessel DBE, Thompson RJ, Gonzales E, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipinski P, Czubkowski P, Rock N, Shagrani M, Broering D, Algoufi T, Mazhar N, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JBF, Serranti D, Arikan C, Debray D, Lacaille F, Goncalves C, Hierro L, Mu?oz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsofi A, Luigi Calvo P, Krebs-Schmitt D, Hartleif S, van der Woerd WL, Wang JS, Li LT, Durmaz ?, Kerkar N, H?rby J?rgensen M, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Targa Ferreira C, Ordonez F, Wang H, Sency V, Mo Kim K, Chen HL, Carvalho E, Fabre A, Quintero Bernabeu J, Alonso EM, Sokol RJ, Suchy FJ, Loomes KM, McKiernan PJ, Rosenthal P, Turmelle Y, Rao GS, Horslen S, Kamath BM, Rogalidou M, Karnsakul WW, Hansen B, Verkade HJ. Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency. Hepatology. 2021 08; 74(2):892-906. PMID: 33666275.
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    16. Johnson KM, Fischer RT, Holtmann GJ, Shah A, Alrabadi L, Lewindon P. Letter to the Editor: Oral Vancomycin Versus No Therapy for Pediatric Primary Sclerosing Cholangitis. Hepatology. 2021 09; 74(3):1716-1717. PMID: 33638221.
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    17. Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J. Big Data in Transplantation Practice-the Devil Is in the Detail-Fontan-associated Liver Disease. Transplantation. 2021 01 01; 105(1):18-22. PMID: 32639398.
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    18. Slowik V, Wasserkrug H, Fischer RT, Connelly M, Deacy AD, Hampl S, Daniel JF. Readiness to Change and Prospective Effects of Weight Management Programs in Pediatric Nonalcoholic Fatty Liver Disease. Clin Transl Sci. 2021 03; 14(2):582-588. PMID: 33142354.
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    19. Ryan JL, Dandridge LM, Fischer RT. Adherence to laboratory testing in pediatric liver transplant recipients. Pediatr Transplant. 2021 May; 25(3):e13899. PMID: 33131187.
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    20. Fischer RT, Day JC, Wasserkrug H, Faseler M, Kats A, Daniel JF, Slowik V, Andrews W, Hendrickson RJ. Complications of Cryptosporidium infection after pediatric liver transplantation: Diarrhea, rejection, and biliary disease. Pediatr Transplant. 2020 12; 24(8):e13807. PMID: 32777150.
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    21. Emamaullee J, Zaidi AN, Schiano T, Kahn J, Valentino PL, Hofer RE, Taner T, Wald JW, Olthoff KM, Bucuvalas J, Fischer R. Fontan-Associated Liver Disease: Screening, Management, and Transplant Considerations. Circulation. 2020 08 11; 142(6):591-604. PMID: 32776846.
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    22. Simon DA, Fleishman NR, Choi P, Fraser JD, Fischer RT. Torsion of an Accessory Spleen in a Child With Biliary Atresia Splenic Malformation Syndrome. Front Pediatr. 2020; 8:220. PMID: 32432066.
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    23. Seng A, Krausz KL, Pei D, Koestler DC, Fischer RT, Yankee TM, Markiewicz MA. Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells. Blood Adv. 2020 04 14; 4(7):1325-1339. PMID: 32259202.
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    24. Tarantino IS, Tennill T, Fraga G, Fischer R. Cutaneous metastases from esophageal adenocarcinoma on the scalp. Cutis. 2020 Mar; 105(3):E3-E4. PMID: 32352439.
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    25. Ryan JL, Dandridge LM, Andrews WS, Daniel JF, Fischer RT, Rivard DC, Wieser AB, Kane BJ, Hendrickson RJ. Conservative Management of Pneumatosis Intestinalis and Portal Venous Gas After Pediatric Liver Transplantation. Transplant Proc. 2020 Apr; 52(3):938-942. PMID: 32122661.
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    26. Sandritter TL, Goldman JL, Habiger CJ, Daniel JF, Lowry J, Fischer RT. An electronic medical records-based approach to identify idiosyncratic drug-induced liver injury in children. Sci Rep. 2019 12 02; 9(1):18090. PMID: 31792283.
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    27. Ng VL, Mazariegos GV, Kelly B, Horslen S, McDiarmid SV, Magee JC, Loomes KM, Fischer RT, Sundaram SS, Lai JC, Te HS, Bucuvalas JC. Barriers to ideal outcomes after pediatric liver transplantation. Pediatr Transplant. 2019 09; 23(6):e13537. PMID: 31343109.
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    28. Landrum Peay H, Fischer R, Tzeng JP, Hesterlee SE, Morris C, Strong Martin A, Rensch C, Smith E, Ricotti V, Beaverson K, Wand H, Mansfield C. Gene therapy as a potential therapeutic option for Duchenne muscular dystrophy: A qualitative preference study of patients and parents. PLoS One. 2019; 14(5):e0213649. PMID: 31042754.
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    29. Halma J, Petrikin J, Daniel JF, Fischer RT. Dehydrated Hereditary Stomatocytosis Presenting as Severe Perinatal Ascites and Cholestasis. J Pediatr Gastroenterol Nutr. 2019 Mar; 68(3):e52-e53. PMID: 29952828.
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    30. Hendrickson RJ, Sujka J, Fischer R, Manalang M, Daniel J, Andrews WS. Indications and efficacy of conversion from tacrolimus- to sirolimus-based immunosuppression in pediatric patients who underwent liver transplantation for unresectable hepatoblastoma. Pediatr Transplant. 2019 05; 23(3):e13369. PMID: 30719825.
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    31. Hollin IL, Peay H, Fischer R, Janssen EM, Bridges JFP. Engaging patients and caregivers in prioritizing symptoms impacting quality of life for Duchenne and Becker muscular dystrophy. Qual Life Res. 2018 Sep; 27(9):2261-2273. PMID: 29804169.
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    32. Sujka J, Gonzalez KW, Curiel KL, Daniel J, Fischer RT, Andrews WS, Wicklund BM, Hendrickson RJ. The impact of thromboelastography on resuscitation in pediatric liver transplantation. Pediatr Transplant. 2018 06; 22(4):e13176. PMID: 29577520.
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    33. Herd TJ, Fischer R, Christensen LC, Rajpara A. Irregular yellow-brown plaques on the trunk and thighs. Cutis. 2018 Jan; 101(1):12;15. PMID: 29529108.
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    34. Akangire G, Cuna A, Lachica C, Fischer R, Raman S, Sampath V. Neonatal Graves' Disease with Maternal Hypothyroidism. AJP Rep. 2017 Jul; 7(3):e181-e184. PMID: 28948062.
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    35. Pant C, Sferra TJ, Fischer RT, Olyaee M, Gilroy R. Epidemiology and Healthcare Resource Utilization Associated With Children With Short Bowel Syndrome in the United States. JPEN J Parenter Enteral Nutr. 2017 07; 41(5):878-883. PMID: 26518221.
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    36. Willig LK, Petrikin JE, Smith LD, Saunders CJ, Thiffault I, Miller NA, Soden SE, Cakici JA, Herd SM, Twist G, Noll A, Creed M, Alba PM, Carpenter SL, Clements MA, Fischer RT, Hays JA, Kilbride H, McDonough RJ, Rosterman JL, Tsai SL, Zellmer L, Farrow EG, Kingsmore SF. Whole-genome sequencing for identification of Mendelian disorders in critically ill infants: a retrospective analysis of diagnostic and clinical findings. Lancet Respir Med. 2015 May; 3(5):377-87. PMID: 25937001.
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    37. Fischer RT, Friend B, Talmon GA, Grant WJ, Quiros-Tejeira RE, Langnas AN, Coccia PF. Intestinal transplantation in children with multiple intestinal atresias and immunodeficiency. Pediatr Transplant. 2014 Mar; 18(2):190-6. PMID: 24373162.
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    38. Infantino BJ, Mercer DF, Hobson BD, Fischer RT, Gerhardt BK, Grant WJ, Langnas AN, Quiros-Tejeira RE. Successful rehabilitation in pediatric ultrashort small bowel syndrome. J Pediatr. 2013 Nov; 163(5):1361-6. PMID: 23866718.
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    39. Acquazzino MA, Fischer RT, Langnas A, Coulter DW. Refractory autoimmune hemolytic anemia after intestinal transplant responding to conversion from a calcineurin to mTOR inhibitor. Pediatr Transplant. 2013 Aug; 17(5):466-71. PMID: 23730873.
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    40. Mercer DF, Hobson BD, Fischer RT, Talmon GA, Perry DA, Gerhardt BK, Grant WJ, Botha JF, Langnas AN, Quiros-Tejeira RE. Hepatic fibrosis persists and progresses despite biochemical improvement in children treated with intravenous fish oil emulsion. J Pediatr Gastroenterol Nutr. 2013 Apr; 56(4):364-9. PMID: 23201707.
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    41. Talmon G, El Behery R, Radio S, Fischer R, Shostrom V, Wisecarver J. Crypt apoptotic count reproducibility in small bowel allograft biopsies. Int J Surg Pathol. 2013 Jun; 21(3):257-60. PMID: 22832111.
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    42. Fischer RT, Turnquist HR, Wang Z, Beer-Stolz D, Thomson AW. Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen-specific CD8(+) T cells in vitro and in vivo. Transpl Immunol. 2011 Jul; 25(1):20-6. PMID: 21596137.
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    43. Fischer RT, Soltys KA, Squires RH, Jaffe R, Mazariegos GV, Shneider BL. Prognostic scoring indices in Wilson disease: a case series and cautionary tale. J Pediatr Gastroenterol Nutr. 2011 Apr; 52(4):466-9. PMID: 21415672.
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    44. Turnquist HR, Fischer RT, Thomson AW. Pharmacological modification of dendritic cells to promote their tolerogenicity in transplantation. Methods Mol Biol. 2010; 595:135-48. PMID: 19941109.
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    45. Fischer R, Shneider B. Treatment of non-alcoholic fatty liver disease in children: swim at your own risk. Pediatr Diabetes. 2009 Feb; 10(1):1-4. PMID: 19161394.
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    46. Fischer R, Turnquist HR, Taner T, Thomson AW. Use of rapamycin in the induction of tolerogenic dendritic cells. Handb Exp Pharmacol. 2009; (188):215-32. PMID: 19031028.
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    47. Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol. 2007 Jun 01; 178(11):7018-31. PMID: 17513751.
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