Multiple Endocrine Neoplasia Type 2b
"Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
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Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Descriptor ID |
D018814
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MeSH Number(s) |
C04.588.322.400.510 C04.651.600.510 C04.700.630.510 C16.320.700.630.510 C19.344.400.510
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Concept/Terms |
Multiple Endocrine Neoplasia Type 2b- Multiple Endocrine Neoplasia Type 2b
- MEN2b
- Multiple Endocrine Neoplasms Type 2b
- Neoplasia, Multiple Endocrine Type 2b
- Neoplasms, Multiple Endocrine Type 2b
- Neuromata, Mucosal, With Endocrine Tumors
- Wagenmann-Froboese Syndrome
- Syndrome, Wagenmann-Froboese
- Wagenmann Froboese Syndrome
- Multiple Endocrine Neoplasia, Type IIb
- MEA 2b
- MEA IIb
- MEN 2b
- MEN 3
- MEN IIb
- MEN III
- Mucosal Neuroma Syndrome
- Mucosal Neuroma Syndromes
- Neuroma Syndrome, Mucosal
- Multiple Endocrine Neoplasia, Type 2b
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