Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
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MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
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Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1993 | 0 | 1 | 1 | 1994 | 0 | 1 | 1 | 1995 | 0 | 1 | 1 | 1996 | 0 | 5 | 5 | 1997 | 0 | 3 | 3 | 1998 | 1 | 4 | 5 | 1999 | 0 | 2 | 2 | 2000 | 0 | 2 | 2 | 2001 | 1 | 3 | 4 | 2002 | 0 | 2 | 2 | 2003 | 0 | 5 | 5 | 2004 | 0 | 4 | 4 | 2005 | 0 | 4 | 4 | 2007 | 0 | 2 | 2 | 2008 | 0 | 3 | 3 | 2009 | 1 | 0 | 1 | 2010 | 0 | 3 | 3 | 2011 | 1 | 2 | 3 | 2012 | 0 | 3 | 3 | 2013 | 0 | 3 | 3 | 2014 | 0 | 1 | 1 | 2015 | 1 | 3 | 4 | 2018 | 0 | 1 | 1 | 2019 | 1 | 0 | 1 | 2020 | 0 | 1 | 1 | 2021 | 2 | 2 | 4 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Finocchario-Kessler S, Wexler C, Brown M, Goggin K, Lwembe R, Nazir N, Gautney B, Khamadi S, Babu S, Muchoki E, Maosa N, Mabachi N, Kamau Y, Maloba M. Piloting the Feasibility and Preliminary Impact of Adding Birth HIV Polymerase Chain Reaction Testing to the Early Infant Diagnosis Guidelines in Kenya. Pediatr Infect Dis J. 2021 08 01; 40(8):741-745.
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Hongkaew Y, Wang WY, Gaedigk R, Sukasem C, Gaedigk A. Resolving discordant CYP2D6 genotyping results in Thai subjects: platform limitations and novel haplotypes. Pharmacogenomics. 2021 06; 22(9):529-541.
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Wexler C, Maloba M, Goggin K, Kale SB, Maosa N, Muchoki E, Brown M, Gautney B, Finocchario-Kessler S. ART Initiation for Infants Diagnosed With HIV Through Point of Care and Conventional Polymerase Chain Reaction Testing in Kenya: A Case Series. Pediatr Infect Dis J. 2021 04 01; 40(4):e151-e153.
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Turner AJ, Aggarwal P, Boone EC, Haidar CE, Relling MV, Derezinski AD, Broeckel U, Gaedigk A. Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization. J Mol Diagn. 2021 05; 23(5):577-588.
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Wexler C, Nazir N, Maloba M, Brown M, Goggin K, Gautney B, Maosa N, Babu S, Muchoki E, Mabachi N, Lwembe R, Finocchario-Kessler S. Programmatic evaluation of feasibility and efficiency of at birth and 6-week, point of care HIV testing in Kenyan infant. PLoS One. 2020; 15(10):e0240621.
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Kanwar N, Crawford J, Ulen C, Uphoff TS, Dien Bard J, Dunn R, Drain A, Selvarangan R. Multicenter Clinical Evaluation of the Automated Aries Group A Strep PCR Assay from Throat Swabs. J Clin Microbiol. 2019 02; 57(2).
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Rea B, Haun P, Emerson R, Vignali M, Farooqi M, Samimi S, Elenitsas R, Kirsch I, Bagg A. Role of high-throughput sequencing in the diagnosis of cutaneous T-cell lymphoma. J Clin Pathol. 2018 Sep; 71(9):814-820.
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Li P, Lee EH, Du F, Gordon RE, Yuelling LW, Liu Y, Ng JM, Zhang H, Wu J, Korshunov A, Pfister SM, Curran T, Yang ZJ. Nestin Mediates Hedgehog Pathway Tumorigenesis. Cancer Res. 2016 09 15; 76(18):5573-83.
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Dodgen TM, Labuschagne CJ, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS. Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort. Pharmacogenomics J. 2016 11; 16(6):566-572.
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Gaedigk A, Riffel AK, Leeder JS. CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele. J Mol Diagn. 2015 Nov; 17(6):740-8.
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