 Mycophenolic Acid
"Mycophenolic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
| Descriptor ID |
D009173
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| MeSH Number(s) |
D02.241.081.193.678 D10.251.618
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mycophenolic Acid".
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This graph shows the total number of publications written about "Mycophenolic Acid" by people in this website by year, and whether "Mycophenolic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mycophenolic Acid" by people in Profiles.
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Mandel M, Elhusseiny AM, Davidson SL, Rockter A, Levin AV, Huang LC, Cheung CSY, Stahl ED, Cooper AM, Jin J, Inger HE, Jordan CO, Jung JL, Utz VM, Angeles-Han ST, Oke I, Nihalani BR. Clinical outcomes in paediatric tubulointerstitial nephritis and uveitis syndrome (TINU). Eye (Lond). 2024 Dec; 38(17):3318-3324.
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Garg U, Munar A, Frazee C. Quantitation of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Serum or Plasma by LC-MS/MS. Curr Protoc. 2023 Apr; 3(4):e730.
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Garg U, Munar A, Frazee C. Determination of Mycophenolic Acid and Mycophenolic Acid Glucuronide Using Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS). Curr Protoc Toxicol. 2018 02 21; 75:18.21.1-18.21.8.
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Banerjee D, Burkard L, Panepinto JC. Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B. PLoS One. 2014; 9(1):e87246.
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Polk BI, Becker ML. Pharmacogenomics in childhood rheumatic disorders: a foundation for future individualized therapy. Discov Med. 2013 Dec; 16(90):267-75.
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Hogg RJ, Friedman A, Greene T, Radeva M, Budisavljevic MN, Gassman J, Gipson DS, Jefferson JA, John EG, Kaskel FJ, Moudgil A, Moxey-Mims M, Ortiz LA, Schelling JR, Schnaper W, Srivastava T, Trachtman H, Vehaskari VM, Wong C, Woronieki RP, Van Why SK, Zolotnitskaya A. Renal function and proteinuria after successful immunosuppressive therapies in patients with FSGS. Clin J Am Soc Nephrol. 2013 Feb; 8(2):211-8.
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Becker ML. Pharmacogenomics in pediatric rheumatology. Curr Opin Rheumatol. 2012 Sep; 24(5):541-7.
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Wu TY, Fridley BL, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen. Int Immunopharmacol. 2011 Aug; 11(8):1057-64.
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Ugrasbul F, Moore WV, Tong PY, Kover KL. Prevention of diabetes: effect of mycophenolate mofetil and anti-CD25 on onset of diabetes in the DRBB rat. Pediatr Diabetes. 2008 Dec; 9(6):596-601.
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Bryan CF, Nelson PW, Shield CF, Warady BA, Winklhofer FT, Murillo D, Wakefield MR. Long-term survival of kidneys transplanted from live A2 donors to O and B recipients. Am J Transplant. 2007 May; 7(5):1181-4.
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