 Medulloblastoma
"Medulloblastoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Descriptor ID |
D008527
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| MeSH Number(s) |
C04.557.465.625.600.380.515 C04.557.465.625.600.590.500 C04.557.470.670.380.515 C04.557.470.670.590.500 C04.557.580.625.600.380.515 C04.557.580.625.600.590.500
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| Concept/Terms |
Melanocytic Medulloblastoma- Melanocytic Medulloblastoma
- Medulloblastoma, Melanocytic
- Medulloblastomas, Melanocytic
- Melanocytic Medulloblastomas
Medulloblastoma, Childhood- Medulloblastoma, Childhood
- Childhood Medulloblastoma
- Childhood Medulloblastomas
- Medulloblastomas, Childhood
Arachnoidal Cerebellar Sarcoma, Circumscribed- Arachnoidal Cerebellar Sarcoma, Circumscribed
- Sarcoma, Cerebellar, Circumscribed Arachnoidal
- Medulloblastoma, Desmoplastic
- Desmoplastic Medulloblastoma
- Desmoplastic Medulloblastomas
- Medulloblastomas, Desmoplastic
Medulloblastoma, Adult- Medulloblastoma, Adult
- Adult Medulloblastoma
- Adult Medulloblastomas
- Medulloblastomas, Adult
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Below are MeSH descriptors whose meaning is more general than "Medulloblastoma".
Below are MeSH descriptors whose meaning is more specific than "Medulloblastoma".
This graph shows the total number of publications written about "Medulloblastoma" by people in this website by year, and whether "Medulloblastoma" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 3 | 0 | 3 | | 2004 | 2 | 0 | 2 | | 2005 | 3 | 0 | 3 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 2 | 0 | 2 | | 2016 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Medulloblastoma" by people in Profiles.
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Du F, Yuelling L, Lee EH, Wang Y, Liao S, Cheng Y, Zhang L, Zheng C, Peri S, Cai KQ, Ng JMY, Curran T, Li P, Yang ZJ. Leukotriene Synthesis Is Critical for Medulloblastoma Progression. Clin Cancer Res. 2019 11 01; 25(21):6475-6486.
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Gordon RE, Zhang L, Peri S, Kuo YM, Du F, Egleston BL, Ng JMY, Andrews AJ, Astsaturov I, Curran T, Yang ZJ. Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. Clin Cancer Res. 2018 03 15; 24(6):1375-1388.
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Liu Y, Yuelling LW, Wang Y, Du F, Gordon RE, O'Brien JA, Ng JMY, Robins S, Lee EH, Liu H, Curran T, Yang ZJ. Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion. Cancer Res. 2017 12 01; 77(23):6692-6703.
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Ginn KF, Fangman B, Terai K, Wise A, Ziazadeh D, Shah K, Gartrell R, Ricke B, Kimura K, Mathur S, Borrego-Diaz E, Farassati F. RalA is overactivated in medulloblastoma. J Neurooncol. 2016 10; 130(1):99-110.
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Li P, Lee EH, Du F, Gordon RE, Yuelling LW, Liu Y, Ng JM, Zhang H, Wu J, Korshunov A, Pfister SM, Curran T, Yang ZJ. Nestin Mediates Hedgehog Pathway Tumorigenesis. Cancer Res. 2016 09 15; 76(18):5573-83.
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Dang MT, Wehrli S, Dang CV, Curran T. The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice. PLoS One. 2015; 10(7):e0133633.
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Robinson GW, Orr BA, Wu G, Gururangan S, Lin T, Qaddoumi I, Packer RJ, Goldman S, Prados MD, Desjardins A, Chintagumpala M, Takebe N, Kaste SC, Rusch M, Allen SJ, Onar-Thomas A, Stewart CF, Fouladi M, Boyett JM, Gilbertson RJ, Curran T, Ellison DW, Gajjar A. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. J Clin Oncol. 2015 Aug 20; 33(24):2646-54.
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Gajjar A, Stewart CF, Ellison DW, Kaste S, Kun LE, Packer RJ, Goldman S, Chintagumpala M, Wallace D, Takebe N, Boyett JM, Gilbertson RJ, Curran T. Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clin Cancer Res. 2013 Nov 15; 19(22):6305-12.
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Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer. 2011 May 26; 11(7):493-501.
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Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9.
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